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paaH1 paaH1 gpsA gpsA h16_A0461 h16_A0461 tyrA tyrA ugd ugd ilvC ilvC paaH2 paaH2 h16_A1239 h16_A1239 h16_A1526 h16_A1526 h16_A1562 h16_A1562 apbA1 apbA1 mtlD mtlD h16_A3004 h16_A3004 proC proC h16_A3600 h16_A3600 wecC wecC h16_B0724 h16_B0724 h16_B0941 h16_B0941 h16_B1190 h16_B1190 h16_B1652 h16_B1652 h16_B1657 h16_B1657 apbA2 apbA2 h16_B1750 h16_B1750 apbA3 apbA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
paaH13-Hydroxyacyl-CoA dehydrogenase. (284 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (338 aa)
h16_A0461Two domain protein: 3-hydroxyacyl-CoA dehydrogenase. (807 aa)
tyrAPrephenate dehydrogenase. (298 aa)
ugdUDP-glucose 6-dehydrogenase. (460 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
paaH23-Hydroxyacyl-CoA dehydrogenase. (507 aa)
h16_A12393-Hydroxyisobutyrate dehydrogenase. (305 aa)
h16_A1526Enoyl-CoA hydratase/Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase. (693 aa)
h16_A15623-Hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+); Belongs to the HIBADH-related family. L-threonate dehydrogenase subfamily. (297 aa)
apbA1Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (312 aa)
mtlDMannitol dehydrogenase. (498 aa)
h16_A30043-Hydroxyisobutyrate dehydrogenase. (293 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (278 aa)
h16_A36002-Hydroxy-3-oxopropionate reductase. (304 aa)
wecCUDP-N-Acetyl-D-mannosamine 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (438 aa)
h16_B0724Enoyl-CoA hydratase/isomerase family; Belongs to the enoyl-CoA hydratase/isomerase family. (692 aa)
h16_B0941NAD-dependent beta-hydroxyacid dehydrogenase. (302 aa)
h16_B11903-Hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (301 aa)
h16_B16523-Hydroxyacyl-CoA dehydrogenase. (322 aa)
h16_B16573-Hydroxyisobutyrate dehydrogenase. (292 aa)
apbA2Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (325 aa)
h16_B17503-Hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (299 aa)
apbA3Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (312 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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