(8 nodes) Thiolase, acyl-enzyme intermediate active site network (Cupriavidus necator)

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Your Input:
	h16_A0462	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	h16_A0872	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	h16_A1290	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
	phaA	Acetyl-CoA acetyltransferase; Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB. (393 aa)
	bktB	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	h16_A1528	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	h16_A1720	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	h16_B0381	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)

Your Current Organism:

Cupriavidus necator

NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bktB	h16_A0462	H16_A1445	H16_A0462	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.710
bktB	h16_A0872	H16_A1445	H16_A0872	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
bktB	h16_A1290	H16_A1445	H16_A1290	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.650
bktB	h16_A1528	H16_A1445	H16_A1528	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.689
bktB	h16_A1720	H16_A1445	H16_A1720	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.663
bktB	h16_B0381	H16_A1445	H16_B0381	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.699
bktB	phaA	H16_A1445	H16_A1438	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB.	0.632
h16_A0462	bktB	H16_A0462	H16_A1445	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	0.710
h16_A0462	h16_A0872	H16_A0462	H16_A0872	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.650
h16_A0462	h16_A1290	H16_A0462	H16_A1290	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.900
h16_A0462	h16_A1528	H16_A0462	H16_A1528	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.706
h16_A0462	h16_A1720	H16_A0462	H16_A1720	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.684
h16_A0462	h16_B0381	H16_A0462	H16_B0381	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.718
h16_A0462	phaA	H16_A0462	H16_A1438	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB.	0.695
h16_A0872	bktB	H16_A0872	H16_A1445	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
h16_A0872	h16_A0462	H16_A0872	H16_A0462	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.650
h16_A0872	h16_A1290	H16_A0872	H16_A1290	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA C-acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.664
h16_A0872	h16_A1528	H16_A0872	H16_A1528	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
h16_A0872	h16_A1720	H16_A0872	H16_A1720	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
h16_A0872	h16_B0381	H16_A0872	H16_B0381	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.600

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