(23 nodes) (2020) Developing a pathway-independent and full-autonomous global resource allocation strategy to dynamically switching phenotypic states. network (Cupriavidus necator)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	h16_B0382	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (256 aa)
	h16_A0142	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (277 aa)
	h16_A1410	Enoyl-CoA hydratase. (567 aa)
	bktB	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	polB	DNA polymerase II. (788 aa)
	h16_A1889	Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family. (254 aa)
	h16_A2054	Protein Translation Elongation Factor TS (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (292 aa)
	cysG	Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (266 aa)
	h16_A3307	Putative enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
	h16_A3311	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (274 aa)
	h16_A3593	Enoyl-CoA hydratase. (259 aa)
	h16_A3594	Enoyl-CoA hydratase. (278 aa)
	h16_B0365	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (276 aa)
	h16_B0389	Enoyl-CoA hydratase. (261 aa)
	h16_B0402	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (278 aa)
	h16_B0419	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa)
	h16_B0420	Enoyl-CoA hydratase. (258 aa)
	h16_B0657	Enoyl-CoA hydratase/carnithine racemase. (295 aa)
	h16_B0659	Enoyl-CoA hydratase/carnithine racemase. (263 aa)
	h16_B0756	Enoyl-CoA hydratase. (291 aa)
	h16_B0848	Enoyl-CoA hydratase. (229 aa)
	h16_B1690	Thioesterase. (272 aa)
	h16_B1741	Enoyl-CoA hydratase. (286 aa)

Your Current Organism:

Cupriavidus necator

NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bktB	h16_A0142	H16_A1445	H16_A0142	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.726
bktB	h16_A1410	H16_A1445	H16_A1410	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.725
bktB	h16_A1889	H16_A1445	H16_A1889	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase/carnithine racemase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.725
bktB	h16_A3307	H16_A1445	H16_A3307	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Putative enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.728
bktB	h16_A3311	H16_A1445	H16_A3311	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.726
bktB	h16_A3593	H16_A1445	H16_A3593	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.726
bktB	h16_A3594	H16_A1445	H16_A3594	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.725
bktB	h16_B0365	H16_A1445	H16_B0365	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.726
bktB	h16_B0382	H16_A1445	H16_B0382	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.725
bktB	h16_B0389	H16_A1445	H16_B0389	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.727
bktB	h16_B0402	H16_A1445	H16_B0402	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.725
bktB	h16_B0419	H16_A1445	H16_B0419	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.726
bktB	h16_B0420	H16_A1445	H16_B0420	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.725
bktB	h16_B0657	H16_A1445	H16_B0657	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase/carnithine racemase.	0.726
bktB	h16_B0659	H16_A1445	H16_B0659	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase/carnithine racemase.	0.725
bktB	h16_B0756	H16_A1445	H16_B0756	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.726
bktB	h16_B0848	H16_A1445	H16_B0848	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.725
bktB	h16_B1690	H16_A1445	H16_B1690	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Thioesterase.	0.410
bktB	h16_B1741	H16_A1445	H16_B1741	Acetyl-CoA acetyltransferase; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta-ketovaleryl- CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase-like superfamily. Thiolase family.	Enoyl-CoA hydratase.	0.726
cysG	h16_A2054	H16_A2994	H16_A2054	Uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.	Protein Translation Elongation Factor TS (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.636

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