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copR copR h16_A0080 h16_A0080 h16_A0081 h16_A0081 h16_A0153 h16_A0153 h16_A0154 h16_A0154 h16_A0202 h16_A0202 h16_A0295 h16_A0295 gltR1 gltR1 h16_A0360 h16_A0360 h16_A0536 h16_A0536 h16_A0543 h16_A0543 h16_A0586 h16_A0586 gltR2 gltR2 cpaE1 cpaE1 pilG pilG pilH pilH pilL2 pilL2 h16_A0781 h16_A0781 cycR1 cycR1 cycS1 cycS1 h16_A1372 h16_A1372 h16_A1427 h16_A1427 h16_A1463 h16_A1463 h16_A1581 h16_A1581 h16_A1757 h16_A1757 h16_A1818 h16_A1818 h16_A2019 h16_A2019 h16_A2020 h16_A2020 h16_A2135 h16_A2135 czrR czrR lytT lytT ntrC ntrC h16_A2379 h16_A2379 phoB phoB h16_A2599 h16_A2599 h16_A3043 h16_A3043 h16_A3044 h16_A3044 h16_A3117 h16_A3117 phcR phcR h16_A3132 h16_A3132 h16_A3237 h16_A3237 h16_A3389 h16_A3389 phhR phhR ntrX ntrX h16_A3710 h16_A3710 h16_A3726 h16_A3726 h16_B0006 h16_B0006 h16_B0042 h16_B0042 h16_B0078 h16_B0078 h16_B0079 h16_B0079 h16_B0125 h16_B0125 cheY3 cheY3 cheB1 cheB1 cheY1 cheY1 cycR2 cycR2 cycS2 cycS2 h16_B0523 h16_B0523 h16_B0524 h16_B0524 h16_B0569 h16_B0569 h16_B0570 h16_B0570 h16_B0621 h16_B0621 h16_B0894 h16_B0894 h16_B1085 h16_B1085 h16_B1086 h16_B1086 h16_B1245 h16_B1245 h16_B1254 h16_B1254 h16_B1459 h16_B1459 h16_B1541 h16_B1541 h16_B1625 h16_B1625 h16_B1626 h16_B1626 h16_B1647 h16_B1647 h16_B1785 h16_B1785 h16_B1970 h16_B1970 h16_B1971 h16_B1971 cheA2Y2 cheA2Y2 cheB2 cheB2 h16_B2050 h16_B2050 h16_B2081 h16_B2081 h16_B2085 h16_B2085 h16_B2087 h16_B2087 h16_B2088 h16_B2088 h16_B2094 h16_B2094 h16_B2197 h16_B2197 cheV cheV h16_B2299 h16_B2299 narL2 narL2 h16_B2348 h16_B2348 h16_B2350 h16_B2350 h16_B2354 h16_B2354 h16_B2435 h16_B2435 h16_B2563 h16_B2563
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
copRResponse regulator of copper response,OmpR-family; REC (residues 3 to 115, 1e-23) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (231 aa)
h16_A0080Response regulator, OmpR-family; REC (residues 8 to 116, 2e-12) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (226 aa)
h16_A0081Response regulator, OmpR-family; REC (residues 11 to 122, 5e-19) with a typical phosphorylation pocket (DD,D54,S/T82,K105). (245 aa)
h16_A0153Response regulator, NarL-family; REC (residues 4 to 118, 3e-23) with a complete phosphorylation pocket (DD-D60-S94-K107). (210 aa)
h16_A0154Response regulator without effector domain; REC (residues 15 to 130, 5e-14) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (135 aa)
h16_A0202Response regulator containing a Fis-type DNA-binding domain; REC (residues 19 to 139, 2e-17) with a complete phosphorylation pocket (DD-D56-T92-K106). (203 aa)
h16_A0295Response regulator, OmpR-family; REC (residues 9 to 120, 7e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (232 aa)
gltR1Response regulator of C4-dicarboxylate transportsystem; REC (residues 11 to 123, 1e-21) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (445 aa)
h16_A0360Response regulator with putative antiterminator output; AmiR. (192 aa)
h16_A0536Response regulator, NarL-family; REC (residues 4 to 118, 9e-12) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (208 aa)
h16_A0543Response regulator, OmpR-family; REC (residues 3 to 115, 8e-25) with a complete phosphorylation pocket (DD-D48-S79-K96). (229 aa)
h16_A0586Response regulator, OmpR-family; REC (residues 9 to 121, 1e-27) with a complete phosphorylation pocket (DD-D55-S78-K96). (247 aa)
gltR2Response regulator of C4-dicarboxylate transportsystem; REC (residues 7 to 119, 1e-23) with a complete phosphorylation pocket (DD-D55-T75-K96). (439 aa)
cpaE1Flp pilus assembly ATPase. (397 aa)
pilGType IV pilus response regulator PilG; REC (residues 37 to 151, 7e-26) with a complete phosphorylation pocket (DD-D55-S86-K98). (163 aa)
pilHType IV pilus response regulator PilH; REC (residues 7 to 121, 7e-25) with a complete phosphorylation pocket (DD-D66-S94-K108). (123 aa)
pilL2Type IV pilus protein histidine kinase/response regulator hybrid PilL; REC (residues1805 to 1919, 6e-21) with a complete phosphorylation pocket (DD-D58-T80-K98). (1941 aa)
h16_A0781Response regulator, NarL-family; REC (residues 4 to 118, 6e-21) with a complete phosphorylation pocket (DD-D50-S82-K111). (216 aa)
cycR1Response regulator containing an adenylate cyclase effector domain; REC (residues 12 to 125, 3e-19) with a complete phosphorylation pocket (DD-D56-T78-K97); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (390 aa)
cycS1Signal transduction histidine kinase containing a receiver domain (hybrid) and a PAS sensor domain. (569 aa)
h16_A1372Response regulator, NarL-family; REC (residues 15 to 127, 4e-24) with a complete phosphorylation pocket (DD-D48-T86-K96). (210 aa)
h16_A1427Response regulator, OmpR-family; REC (residues 3 to 114, 1e-23) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (223 aa)
h16_A1463Response regulator, OmpR-family; REC (residues 8 to 120, 9e-31) with a complete phosphorylation pocket (DD-D55-T75-K96). (240 aa)
h16_A1581Predicted signal transduction protein containingan EAL domain. (408 aa)
h16_A1757Response regulator, OmpR-family; REC (residues 8 to 121, 6e-25) with a complete phosphorylation pocket (DD-D55-T82-K97). (204 aa)
h16_A1818Response regulator, OmpR-family; REC (residues 5 to 117, 5e-26) with a complete phosphorylation pocket (DD-D55-T96-K108). (232 aa)
h16_A2019Response regulator; REC (residues 34 to 126, 4e-04) with an incomplete phosphorylation pocket (only D54,S/T82). (132 aa)
h16_A2020Response regulator, NarL-family; REC (residues 4 to 118, 2e-21) with a complete phosphorylation pocket (DD-D50-T77-K98). (215 aa)
h16_A2135Response regulator, NarL-family; REC (residues 14 to 127, 2e-18) with a complete phosphorylation pocket (DD-D59-T81-K97). (192 aa)
czrRResponse regulator involved in heavy metal response, OmpR-family; REC (residues 3 to 113, 4e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (227 aa)
lytTResponse regulator containing a LytTR DNA-binding domain; REC (residues 5 to 117, 2e-17) with a complete phosphorylation pocket (DD-D51-T78-K97). (274 aa)
ntrCResponse regulator, nitrogen regulation protein NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (515 aa)
h16_A2379Response regulator, OmpR-family; REC (residues 3 to 115, 2e-25) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (224 aa)
phoBResponse regulator, phosphate regulon transcriptional regulator PhoB, OmpR-family; REC (residues 5 to 119, 2e-26) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (235 aa)
h16_A2599Response regulator, OmpR-family; REC (residues 9 to 119, 3e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (231 aa)
h16_A3043Response regulator, NarL-family; REC (residues 8 to 123, 8e-14) with a complete phosphorylation pocket (DD-D61-S93-K112). (219 aa)
h16_A3044Signal transduction histidine kinase containing a receiver domain (hybrid); 5 TMHs. (572 aa)
h16_A3117Response regulator. (335 aa)
phcRSignal transduction histidine kinase containing a receiver domain (hybrid); REC (residues 11 to 125, 3e-14) with a complete phosphorylation pocket (DD-D56-T87-K98). (381 aa)
h16_A3132Response regulator containing an atypical phosphorylation pocket; REC (residues103 to 159, 2e-06) with an incomplete phosphorylation pocket (only 1/2 DD,D54). (348 aa)
h16_A3237Response regulator containing sigma54 activator and Fis-type DNA-binding domains; REC (residues 26 to 138, 4e-21) with a complete phosphorylation pocket (DD-D53-S79-K96). (555 aa)
h16_A3389Response regulator containing a LytTR DNA-binding domain; REC (residues 5 to 114, 1e-16) with a complete phosphorylation pocket (DD-D51-T75-K94). (253 aa)
phhRResponse regulator, OmpR-family; REC (residues 3 to 115, 2e-22) with a complete phosphorylation pocket (DD-D55-S85-K96). (234 aa)
ntrXResponse regulator containing a Fis-type DNA-binding domain, NtrX; REC (residues 4 to 117, 2e-23) with a complete phosphorylation pocket (DD-D55-T88-K103). (236 aa)
h16_A3710Response regulator, NarL-family; REC (residues 14 to 132, 9e-18) with a complete phosphorylation pocket (DD-D54-S81-K102). (224 aa)
h16_A3726Response regulator, OmpR-family; REC (residues 3 to 115, 4e-24) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (224 aa)
h16_B0006Response regulator, NarL-family; REC (residues 4 to 118, 0.003) with a typical phosphorylation pocket (D54,S/T82,K105). (286 aa)
h16_B0042Response regulator, NarL-family; REC (residues 3 to 117, 7e-05) with a typical phosphorylation pocket (D54,S/T82,K105). (318 aa)
h16_B007814 TMHs; REC (residues 924 to 1036, 1e-20) with a complete phosphorylation pocket (DD-D58-T82-K96). (1111 aa)
h16_B0079Response regulator, NarL-family; REC (residues 18 to 130, 3e-25) with a complete phosphorylation pocket (DD-D55-T80-K96). (297 aa)
h16_B0125Response regulator, NarL-family; REC (residues 4 to 118, 2e-19) with a complete phosphorylation pocket (DD-D60-S88-K103). (209 aa)
cheY3Chemotaxis response regulator; REC (residues 6 to 120, 2e-25) with a complete phosphorylation pocket (DD-D55-S83-K98). (130 aa)
cheB1Chemotaxis specific response regulator containing a methylesterase domain; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (360 aa)
cheY1Chemotaxis response regulator; REC (residues 7 to 122, 7e-23) with a complete phosphorylation pocket (DD-D56-T78-K112). (128 aa)
cycR2Response regulator containing an adenylate cyclase effector domain; REC (residues 12 to 125, 4e-20) with a complete phosphorylation pocket (DD-D56-T78-K97); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (395 aa)
cycS2Signal transduction histidine kinase containing a receiver domain (hybrid) and a PAS sensor domain; REC (residues376 to 491, 3e-21) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (503 aa)
h16_B0523Response regulator, NarL-family; REC (residues 25 to 139, 1e-11) with a complete phosphorylation pocket (DD-D56-S78-K99). (229 aa)
h16_B0524Signal transduction histidine kinase containing a receiver domain (hybrid); REC (residues481 to 594, 2e-11) with a complete phosphorylation pocket (DD-D49-S82-K97). (598 aa)
h16_B0569Response regulator, NarL-family; REC (residues 11 to 123, 4e-18) with a complete phosphorylation pocket (DD-D56-S78-K97). (219 aa)
h16_B0570Signal transduction histidine kinase containing a receiver domain (hybrid); 5 TMHs; REC (residues 475 to 594, 1e-06) with a complete phosphorylation pocket (DD-D54-T86-K103). (601 aa)
h16_B0621Response regulator, NarL-family; REC (residues 17 to 132, 1e-16) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (235 aa)
h16_B0894Response regulator; REC (residues 9 to 120, 1e-25) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105); response regulator, OmpR-family. (231 aa)
h16_B1085Two-component system, NarL family, sensor histidine kinase EvgS; 1 TMHs; REC (residues 432 to 546, 2e-20) with a complete phosphorylation pocket (DD-D55-S80-K99). (608 aa)
h16_B1086Response regulator, NarL-family; REC (residues 4 to 118, 1e-18) with a complete phosphorylation pocket (DD-D60-T83-K98). (208 aa)
h16_B1245Response regulator, OmpR-family; REC (residues 3 to 115, 3e-26) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (224 aa)
h16_B1254Response regulator, OmpR-family; REC (residues 17 to 115, 3e-13) with an incomplete phosphorylation pocket (only D54). (251 aa)
h16_B1459Response regulator containing sigma54 activator and Fis-type DNA-binding domains; REC (residues 19 to 131, 3e-23) with a complete phosphorylation pocket (DD-D48-T82-K96). (467 aa)
h16_B1541Signal transduction histidine kinase containing a receiver domain (hybrid) and PAS sensor domains; REC (residues546 to 659, 4e-19) with a complete phosphorylation pocket (DD-D55-T88-K98). (664 aa)
h16_B1625Signal transduction histidine kinase containing a receiver domain (hybrid); REC (residues752 to 864, 6e-23) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (997 aa)
h16_B1626Response regulator, NarL-family; REC (residues 8 to 120, 2e-11) with a complete phosphorylation pocket (DD-D61-T90-K102). (216 aa)
h16_B1647Response regulator, OmpR-family; REC (residues 3 to 114, 2e-25) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (229 aa)
h16_B1785Response regulator, OmpR-family; REC (residues 8 to 121, 4e-25) with a complete phosphorylation pocket (DD-D55-T82-K109). (247 aa)
h16_B1970Response regulator, NarL-family. (215 aa)
h16_B1971Sensor protein rcsC. (1131 aa)
cheA2Y2Chemotaxis specific sensory transducer kinase,group IIIA, containing a receiver domain (hybrid); REC (residues 630 to 745, 5e-21) with a complete phosphorylation pocket (DD-D55-S77-K98). (751 aa)
cheB2Chemotaxis response regulator containing a methylesterase domain; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (339 aa)
h16_B2050Response regulator containing a GGDEF effector domain; REC (residues 22 to 134, 2e-17) with a complete phosphorylation pocket (DD-D56-T85-K99). (339 aa)
h16_B2081Response regulator, NarL family. (221 aa)
h16_B2085Signal transduction histidine kinase containing a receiver domain (hybrid); 3 TMHs; REC (residues 875 to 986, 7e-23) with a typical phosphorylation pocket (1/2 DD,D54,S/T82,K105). (1106 aa)
h16_B2087Response regulator, NarL-family; REC (residues 4 to 121, 3e-14) with a complete phosphorylation pocket (DD-D60-T80-K101). (213 aa)
h16_B2088Signal transduction histidine kinase containing a receiver domain (hybrid); 2 TMHs; REC (residues 869 to 981, 1e-25) with a complete phosphorylation pocket (DD-D55-S77-K96). (1109 aa)
h16_B2094Response regulator, OmpR-family; REC (residues 12 to 123, 1e-23) with a complete phosphorylation pocket (DD-D53-T74-K103). (240 aa)
h16_B2197Response regulator, OmpR-family; REC (residues 5 to 116, 5e-24) with a complete phosphorylation pocket (DD-D46-S80-K95). (242 aa)
cheVChemotaxis specific response regulator containing a CheW-domain; REC (residues195 to 319, 8e-14) with a complete phosphorylation pocket (DD-D59-S95-K113). (322 aa)
h16_B2299Response regulator, NarL-family; REC (residues 7 to 118, 2e-17) with a complete phosphorylation pocket (DD-D61-S89-K99). (224 aa)
narL2Response regulator, NarL-family. (218 aa)
h16_B2348Response regulator containing sigma54 activator and Fis-type DNA-binding domains; REC (residues 4 to 114, 3e-16) with a complete phosphorylation pocket (DD-D53-S80-K94). (466 aa)
h16_B2350Signal transduction histidine kinase containing a receiver domain (hybrid); REC (residues548 to 660, 2e-19) with a complete phosphorylation pocket (DD-D53-S88-K98). (668 aa)
h16_B2354Signal transduction histidine kinase containing two receiver domains (hybrid). (669 aa)
h16_B2435Response regulator, NarL-family; REC (residues 19 to 134, 3e-14) with a typical phosphorylation pocket (D54,S/T82,K105). (239 aa)
h16_B2563Response regulator, OmpR-family; REC (residues 3 to 120, 2e-24) with a complete phosphorylation pocket (DD-D53-T80-K101). (237 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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