STRINGSTRING
glmU glmU glmS glmS nagE nagE nagA nagA nagB nagB fruA fruA h16_A0507 h16_A0507 h16_A0510 h16_A0510 h16_A0786 h16_A0786 ugd ugd pgi1 pgi1 manB1 manB1 manC1 manC1 manB3 manB3 h16_A2550 h16_A2550 galU galU manB2 manB2 rfbF rfbF h16_A2896 h16_A2896 h16_A2899 h16_A2899 h16_A2900 h16_A2900 manC2 manC2 h16_A3024 h16_A3024 murB murB murA murA wbpE wbpE wbpD wbpD wbpB wbpB wecC wecC galE galE h16_B0283 h16_B0283 pgi2 pgi2 frcK frcK h16_B1640 h16_B1640 h16_B1877 h16_B1877 glk glk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
glmUUDP-N-acetylglucosamine pyrophosphorylase/Glucosamine-1-phosphate acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the trans [...] (454 aa)
glmSGlutamine-fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (612 aa)
nagEProtein-N(pi)-phosphohistidine-sugar phosphotransferase II ABC, N-acetylglucosamine-specific; 14 TMHs. (569 aa)
nagAN-Acetylglucosamine-6-phosphate deacetylase. (367 aa)
nagBGlucosamine-6-phosphate deaminase. (343 aa)
fruAPhosphotransferase system, fructose-specific component IIA. (151 aa)
h16_A0507Nucleoside-diphosphate-sugar pyrophosphorylase. (247 aa)
h16_A0510Predicted phosphotransferase to Ser/Thr protein kinases. (344 aa)
h16_A0786Predicted phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (224 aa)
ugdUDP-glucose 6-dehydrogenase. (460 aa)
pgi1Glucose-6-phosphate isomerase; Belongs to the GPI family. (547 aa)
manB1Phosphomannomutase. (461 aa)
manC1Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (509 aa)
manB3Phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (447 aa)
h16_A2550Beta-glucosidase-related glycosidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (349 aa)
galUUTP-glucose-1-phosphate uridylyltransferase. (296 aa)
manB2Phosphomannomutase. (461 aa)
rfbFPutative glucose-1-phosphate cytidylyltransferase. (257 aa)
h16_A2896NAD dependent sugar epimerase. (360 aa)
h16_A2899Nucleoside-diphosphate-sugar epimerase. (266 aa)
h16_A2900GDP-D-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (346 aa)
manC2Mannose-1-phosphate guanylyltransferase; Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa)
h16_A30242-Polyprenylphenol hydroxylase. (352 aa)
murBUDP-N-acetylmuramate dehydrogenase; Cell wall formation. (336 aa)
murAUDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (416 aa)
wbpEProbable aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (371 aa)
wbpDAcetyltransferase. (193 aa)
wbpBLipopolysaccharide biosynthesis protein. (316 aa)
wecCUDP-N-Acetyl-D-mannosamine 6-dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (438 aa)
galEUDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (339 aa)
h16_B0283UDP-glucose 4-epimerase. (319 aa)
pgi2Glucose-6-phosphate isomerase; Belongs to the GPI family. (544 aa)
frcKFructokinase. (303 aa)
h16_B1640Glycosyltransferase involved in cell wall biogenesis. (323 aa)
h16_B1877Putative oxidoreductase. (332 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (337 aa)
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.