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Fnod_0043 Fnod_0043 Fnod_0044 Fnod_0044 Fnod_0055 Fnod_0055 Fnod_0056 Fnod_0056 glyA glyA Fnod_0088 Fnod_0088 Fnod_0110 Fnod_0110 Fnod_0111 Fnod_0111 Fnod_0112 Fnod_0112 Fnod_0113 Fnod_0113 Fnod_0206 Fnod_0206 Fnod_0230 Fnod_0230 Fnod_0314 Fnod_0314 Fnod_0464 Fnod_0464 Fnod_0465 Fnod_0465 Fnod_0471 Fnod_0471 Fnod_0520 Fnod_0520 Fnod_0521 Fnod_0521 Fnod_0532 Fnod_0532 Fnod_0585 Fnod_0585 prs prs Fnod_0607 Fnod_0607 apgM apgM tpiA tpiA pgk pgk Fnod_0740 Fnod_0740 ackA ackA Fnod_0761 Fnod_0761 Fnod_0790 Fnod_0790 Fnod_0863 Fnod_0863 Fnod_0864 Fnod_0864 Fnod_0865 Fnod_0865 Fnod_0866 Fnod_0866 pgi pgi gcvPB gcvPB gcvPA gcvPA gcvT gcvT Fnod_0985 Fnod_0985 gcvH gcvH Fnod_1064 Fnod_1064 fhs fhs Fnod_1199 Fnod_1199 tal tal Fnod_1253 Fnod_1253 Fnod_1279 Fnod_1279 Fnod_1311 Fnod_1311 Fnod_1312 Fnod_1312 Fnod_1316 Fnod_1316 Fnod_1322 Fnod_1322 folD folD Fnod_1343 Fnod_1343 Fnod_1351 Fnod_1351 Fnod_1378 Fnod_1378 Fnod_1379 Fnod_1379 Fnod_1444 Fnod_1444 Fnod_1474 Fnod_1474 Fnod_1475 Fnod_1475 pfp pfp pfkA pfkA Fnod_1680 Fnod_1680 eno eno Fnod_1752 Fnod_1752 Fnod_1788 Fnod_1788
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Fnod_0043PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tpt:Tpet_0515 thiamine pyrophosphate enzyme domain protein TPP-binding. (273 aa)
Fnod_0044PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: tpt:Tpet_0514 pyruvate ferredoxin/flavodoxin oxidoreductase. (198 aa)
Fnod_0055PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tpt:Tpet_1585 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (561 aa)
Fnod_0056TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tpt:Tpet_1584 pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit. (276 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
Fnod_0088PFAM: ROK family protein; KEGG: tpt:Tpet_1323 ROK family protein. (313 aa)
Fnod_0110PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: tma:TM1758 2-oxoisovalerate ferredoxin oxidoreductase, delta subunit. (76 aa)
Fnod_0111PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tpt:Tpet_1046 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (353 aa)
Fnod_0112PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tpt:Tpet_1047 thiamine pyrophosphate enzyme domain protein TPP-binding. (251 aa)
Fnod_0113TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: tpt:Tpet_1048 pyruvate ferredoxin/flavodoxin oxidoreductase. (179 aa)
Fnod_0206PFAM: MaoC domain protein dehydratase; KEGG: MaoC family protein. (133 aa)
Fnod_0230TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: tma:TM0381 dihydrolipoamide dehydrogenase. (454 aa)
Fnod_0314TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: cps:CPS_2626 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
Fnod_0464PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: tma:TM0665 cysteine synthase. (294 aa)
Fnod_0465KEGG: tma:TM0666 serine acetyltransferase. (221 aa)
Fnod_0471Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: tpt:Tpet_0379 malate dehydrogenase (oxaloacetate-decarboxylating). (376 aa)
Fnod_0520PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region; KEGG: tpt:Tpet_0380 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit. (160 aa)
Fnod_0521TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region; KEGG: tma:TM0540 fumarate hydratase alpha subunit. (277 aa)
Fnod_0532KEGG: tte:TTE0554 acetyl-CoA hydrolase. (432 aa)
Fnod_0585PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase type 2 domain; KEGG: tte:TTE0545 Acyl-CoA dehydrogenases. (379 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
Fnod_0607TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; KEGG: tma:TM0272 pyruvate,orthophosphate dikinase; Belongs to the PEP-utilizing enzyme family. (881 aa)
apgMPhosphonopyruvate decarboxylase-related protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (401 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (243 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: tma:TM0689 phosphoglycerate kinase / triose-phosphate isomerase; Belongs to the phosphoglycerate kinase family. (400 aa)
Fnod_0740TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: tma:TM0688 glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (406 aa)
Fnod_0761TIGRFAM: ketose-bisphosphate aldolase; fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; KEGG: tpt:Tpet_0651 fructose-1,6-bisphosphate aldolase, class II. (330 aa)
Fnod_0790TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase; KEGG: tpt:Tpet_1664 ribose 5-phosphate isomerase B. (145 aa)
Fnod_0863PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tpt:Tpet_0905 thiamine pyrophosphate enzyme domain protein TPP-binding. (324 aa)
Fnod_0864PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tpt:Tpet_0906 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (389 aa)
Fnod_0865TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: tpt:Tpet_0907 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit. (116 aa)
Fnod_0866TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: tpt:Tpet_0908 pyruvate/ketoisovalerate oxidoreductase, gamma subunit. (217 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: tma:TM1385 glucose-6-phosphate isomerase; Belongs to the GPI family. (453 aa)
gcvPBGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (477 aa)
gcvPAGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (441 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (430 aa)
Fnod_0985PFAM: ribulose-phosphate 3-epimerase; KEGG: tpt:Tpet_1014 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (212 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa)
Fnod_1064PFAM: Glu/Leu/Phe/Val dehydrogenase; Glu/Leu/Phe/Val dehydrogenase dimerisation region; KEGG: tma:TM1015 glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (427 aa)
fhsPFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: tma:TM1766 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (552 aa)
Fnod_1199Propanediol utilization protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (195 aa)
talPutative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
Fnod_1253Hydroxypyruvate reductase; PFAM: MOFRL domain protein; KEGG: tma:TM1585 glycerate kinase, putative. (412 aa)
Fnod_1279PFAM: methylenetetrahydrofolate reductase; KEGG: sru:SRU_2094 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (313 aa)
Fnod_1311PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: tma:TM0879 ferredoxin. (82 aa)
Fnod_1312PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tma:TM0878 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (389 aa)
Fnod_1316PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: pfu:PF1948 lactoylglutathione lyase. (135 aa)
Fnod_1322PFAM: cobalamin B12-binding domain protein; KEGG: pab:PAB2187 methylmalonyl-CoA mutase, subunit alpha, C-terminus. (136 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (272 aa)
Fnod_13436-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (333 aa)
Fnod_1351PFAM: PfkB domain protein; KEGG: deb:DehaBAV1_1157 1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (309 aa)
Fnod_1378Succinate--CoA ligase (ADP-forming); PFAM: ATP-citrate lyase/succinyl-CoA ligase; ATP-grasp domain protein; KEGG: mja:MJ0210 succinyl-CoA synthetase beta chain. (355 aa)
Fnod_1379PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; KEGG: mka:MK0732 succinyl-CoA synthetase alpha subunit. (285 aa)
Fnod_1444KEGG: lpl:lp_3418 phosphoenolpyruvate carboxykinase (ATP). (543 aa)
Fnod_1474TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain; KEGG: tte:TTE1009 L-serine deaminase. (290 aa)
Fnod_1475TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: serine dehydratase beta chain; KEGG: cpf:CPF_2959 L-serine dehydratase, iron-sulfur-dependent, beta subunit. (220 aa)
pfpPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (422 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (335 aa)
Fnod_1680PFAM: Transketolase domain protein; Transketolase central region; KEGG: tma:TM1762 transketolase. (623 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
Fnod_1752TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase; KEGG: tte:TTE2389 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (554 aa)
Fnod_1788TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: tte:TTE0533 Carbamate kinase; Belongs to the carbamate kinase family. (311 aa)
Your Current Organism:
Fervidobacterium nodosum
NCBI taxonomy Id: 381764
Other names: F. nodosum Rt17-B1, Fervidobacterium nodosum Rt17-B1, Fervidobacterium nodosum str. Rt17-B1, Fervidobacterium nodosum strain Rt17-B1
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