STRINGSTRING
ahcY ahcY metB metB AIL97995.1 AIL97995.1 AIL98020.1 AIL98020.1 AIL98168.1 AIL98168.1 cysK cysK AIL98211.1 AIL98211.1 AIL98265.1 AIL98265.1 metZ metZ AIL98596.1 AIL98596.1 AIL98632.1 AIL98632.1 AIL98645.1 AIL98645.1 AIL98714.1 AIL98714.1 AIL98715.1 AIL98715.1 AIL98716.1 AIL98716.1 AIL98717.1 AIL98717.1 tldD tldD AIL98725.1 AIL98725.1 thrB thrB AIL98765.1 AIL98765.1 cysN cysN cysD cysD cysH cysH AIL98769.1 AIL98769.1 AIL98770.1 AIL98770.1 pepN pepN cysS cysS pepA pepA AIL99025.1 AIL99025.1 AIL99070.1 AIL99070.1 AIL99217.1 AIL99217.1 AIL99293.1 AIL99293.1 cobA cobA AIL99295.1 AIL99295.1 AIL99296.1 AIL99296.1 AIL99297.1 AIL99297.1 AIL99298.1 AIL99298.1 AIL99304.1 AIL99304.1 cysE cysE AIL99488.1 AIL99488.1 AIL99624.1 AIL99624.1 hemF hemF bluB bluB cobT cobT cobS cobS cobD cobD AIL99812.1 AIL99812.1 cobB cobB cobA-2 cobA-2 AIL99815.1 AIL99815.1 cobO cobO cobN cobN AIL99827.1 AIL99827.1 cobQ cobQ bmt bmt AIL99840.1 AIL99840.1 AIL99841.1 AIL99841.1 AIL99842.1 AIL99842.1 AIL99843.1 AIL99843.1 AIL99844.1 AIL99844.1 AIL99845.1 AIL99845.1 AIL99847.1 AIL99847.1 AIL99850.1 AIL99850.1 AIL99851.1 AIL99851.1 AIL99852.1 AIL99852.1 AIL99853.1 AIL99853.1 AIL99854.1 AIL99854.1 AIL99855.1 AIL99855.1 AIL99856.1 AIL99856.1 AIL99857.1 AIL99857.1 AIL99959.1 AIL99959.1 metF metF AIM00223.1 AIM00223.1 AIM00228.1 AIM00228.1 cysQ cysQ AIM00589.1 AIM00589.1 cobT-2 cobT-2 cobS-2 cobS-2 hemH hemH AIM00832.1 AIM00832.1 AIM00833.1 AIM00833.1 metN metN cobM cobM AIM00862.1 AIM00862.1 AIM01219.1 AIM01219.1 AIM00863.1 AIM00863.1 AIM00864.1 AIM00864.1 cobH cobH cobG cobG AIM00867.1 AIM00867.1 AIM00920.1 AIM00920.1 hemA hemA hemC hemC AIM01018.1 AIM01018.1 metAA metAA hemJ hemJ hemE hemE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (466 aa)
metBCatalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
AIL97995.1Cytochrome C oxidase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase M17 family. (463 aa)
AIL98020.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
AIL98168.15'-methylthioadenosine nucleosidase; Enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
cysKCysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
AIL98211.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
AIL98265.1S-adenosylmethionine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AdoMet synthase family. (426 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (394 aa)
AIL98596.1Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (457 aa)
AIL98632.1Modulator protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
AIL98645.1Trimethylamine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the trimethylamine methyltransferase family. (514 aa)
AIL98714.1Biotin biosynthesis protein BioC; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
AIL98715.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
AIL98716.1Cobalt ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
AIL98717.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
tldDProtease TldD; Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AIL98725.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (194 aa)
thrBSerine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudomonas-type ThrB family. (326 aa)
AIL98765.1XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
cysNSulfate adenylyltransferase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (498 aa)
cysDSulfate adenylyltransferase subunit 2; With CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (265 aa)
AIL98769.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
AIL98770.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
pepNDerived by automated computational analysis using gene prediction method: Protein Homology. (884 aa)
cysScysteine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (466 aa)
pepAAminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (497 aa)
AIL99025.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (337 aa)
AIL99070.1O-acetylhomoserine aminocarboxypropyltransferase; Catalyzes the formation of L-methionine and acetate from O-acetyl-L-homoserine and methanethiol; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
AIL99217.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
AIL99293.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
cobASiroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (485 aa)
AIL99295.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AIL99296.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (557 aa)
AIL99297.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
AIL99298.1ferredoxin-NADP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
AIL99304.1Cystathionine beta-lyase; Catalyzes the formation of L-homocysteine from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
cysESerine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (275 aa)
AIL99488.1Cysteine synthase; CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
AIL99624.14-hydroxyphenylacetate 3-monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (303 aa)
bluBcob(II)yrinic acid a,c-diamide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (338 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (262 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (327 aa)
AIL99812.1Alpha-ribazole phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (333 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (429 aa)
cobA-2uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (279 aa)
AIL99815.1Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
cobOCobinamide adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (214 aa)
cobNCobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. (1275 aa)
AIL99827.1Cobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (175 aa)
cobQCobalamin biosynthesis protein CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (484 aa)
bmtCatalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
AIL99840.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
AIL99841.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
AIL99842.1Signal peptide protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
AIL99843.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
AIL99844.1Trimethylamine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the trimethylamine methyltransferase family. (524 aa)
AIL99845.15-methyltetrahydrofolate--homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
AIL99847.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
AIL99850.1Response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
AIL99851.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
AIL99852.1Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AIL99853.1Methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (363 aa)
AIL99854.1Methyltetrahydrofolate:corrinoid methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
AIL99855.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
AIL99856.1Drug:proton antiporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (683 aa)
AIL99857.1Chloramphenicol phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
AIL99959.1C-5 cytosine-specific DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa)
metF5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (313 aa)
AIM00223.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the trimethylamine methyltransferase family. (514 aa)
AIM00228.1Methionine gamma-lyase; Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
cysQ3'-5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (258 aa)
AIM00589.1cob(I)yrinic acid a c-diamide adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa)
cobT-2Cobalt chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (631 aa)
cobS-2Cobalamin biosynthesis protein CobS; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (342 aa)
AIM00832.1Dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
AIM00833.1DL-methionine transporter permease subunit; Part of the MetNIQ methionine uptake system; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
metNMethionine ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (358 aa)
cobMPrecorrin-4 C11-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (252 aa)
AIM00862.1precorrin-6Y methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
AIM01219.1cobalt-precorrin-6X reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
AIM00863.1Catalyzes the formation of precorrin-4 from precorrin-3B and S-adenosyl-L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
AIM00864.1Catalyzes the formation of precorrin-3 from precorrin-2; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
cobHCatalyzes the interconversion of precorrin-8X and hydrogenobyrinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
cobGprecorrin-3B synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
AIM00867.1Precorrin 6A synthase; Catalyzes the methylation of C-1 in precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A. (256 aa)
AIM00920.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1257 aa)
hemACatalyzes the formation of 5-aminolevulinate from succinyl-CoA and glycine; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (309 aa)
AIM01018.1Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (235 aa)
metAAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (331 aa)
hemJHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (180 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (319 aa)
Your Current Organism:
Sinorhizobium meliloti
NCBI taxonomy Id: 382
Other names: ATCC 9930, CCUG 27879, CFBP 5561, DSM 30135, Ensifer meliloti, Ensifer sp. AC50a, Ensifer sp. AC50e, HAMBI 2148, IAM 12611, ICMP 12623, IFO 14782, JCM 20682, LMG 6133, LMG:6133, NBRC 14782, NCAIM B.01520, NRRL L-45, NZP 4027, Rhizobium meliloti, Rhizobium meliloti (megaplasmid pRME41B SYM), Rhizobium meliloti (plasmid pRmeGR4b), Rhizobium meliloti plasmid pRmeGR4b, Rhizobium sp. AC50e, S. meliloti
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