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pyrF pyrF SPRI_1386 SPRI_1386 SPRI_1473 SPRI_1473 SPRI_1549 SPRI_1549 dut dut tdk tdk SPRI_2100 SPRI_2100 SPRI_2112 SPRI_2112 thyX thyX SPRI_2648 SPRI_2648 SPRI_2649 SPRI_2649 SPRI_2968 SPRI_2968 purH purH purN purN guaA guaA SPRI_3115 SPRI_3115 guaB guaB adk adk SPRI_3379 SPRI_3379 tmk tmk purA purA pyrE pyrE upp upp purD purD purC purC purS purS purQ purQ purL purL purF purF purM purM purK purK purE purE SPRI_4594 SPRI_4594 ndk ndk apt apt SPRI_6050 SPRI_6050 pyrR pyrR pyrB pyrB pyrC pyrC SPRI_6083 SPRI_6083 carA carA carB carB pyrD pyrD pyrF-2 pyrF-2 gmk gmk SPRI_6102 SPRI_6102 SPRI_6110 SPRI_6110 SPRI_6278 SPRI_6278
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrFPutative integron gene cassette protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (231 aa)
SPRI_1386Aminotransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (242 aa)
SPRI_1473Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (145 aa)
SPRI_1549Uracil permease; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (468 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (170 aa)
tdkThymidine kinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (216 aa)
SPRI_2100Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (964 aa)
SPRI_2112Kinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (692 aa)
thyXFAD-dependent thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
SPRI_2648Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (782 aa)
SPRI_2649Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (337 aa)
SPRI_2968Uridine kinase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (202 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (520 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (245 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (531 aa)
SPRI_3115Inosine-5-monophosphate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (374 aa)
guaBInosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (499 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (221 aa)
SPRI_3379Exopolyphosphatase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (310 aa)
tmkKinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (1026 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (220 aa)
purDPhosphoribosylamine--glycine ligase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (420 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (299 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (81 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (226 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (749 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (550 aa)
purMPhosphoribosylaminoimidazole synthetase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (366 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (372 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa)
SPRI_4594UPF0301 protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (186 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
SPRI_6050GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (827 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (192 aa)
pyrBAspartate carbamoyltransferase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (327 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
SPRI_6083Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (183 aa)
carACarbamoyl phosphate synthase small subunit; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (378 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1102 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (369 aa)
pyrF-2Orotidine 5'-phosphate decarboxylase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (280 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (187 aa)
SPRI_6102Inosine-5-monophosphate dehydrogenase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (480 aa)
SPRI_6110Nitrate reductase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (488 aa)
SPRI_6278Adenylosuccinate lyase; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (480 aa)
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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