STRINGSTRING
SPRI_1779 SPRI_1779 SPRI_1048 SPRI_1048 SPRI_0044 SPRI_0044 rpsD rpsD infC infC SPRI_5680 SPRI_5680 SPRI_5663 SPRI_5663 infA infA SPRI_3159 SPRI_3159 rplM rplM SPRI_2839 SPRI_2839 SPRI_5263 SPRI_5263 SPRI_5186 SPRI_5186 SPRI_6478 SPRI_6478 hpf hpf SPRI_7309 SPRI_7309 SPRI_6902 SPRI_6902 fusA fusA infB infB tsf tsf prfA prfA SPRI_2768 SPRI_2768 prfB prfB tuf-2 tuf-2 lepA lepA rsfS rsfS SPRI_4839 SPRI_4839 SPRI_4095 SPRI_4095 SPRI_4229 SPRI_4229 SPRI_4851 SPRI_4851 SPRI_6627 SPRI_6627 SPRI_6257 SPRI_6257 fusA-2 fusA-2 tuf tuf efp efp rplA rplA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRI_1779Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (325 aa)
SPRI_1048ABC transporter ATP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (547 aa)
SPRI_0044Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (591 aa)
rpsD30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (204 aa)
infCTranslation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (216 aa)
SPRI_5680ABC transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (532 aa)
SPRI_5663Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (246 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa)
SPRI_3159ABC transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (540 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (147 aa)
SPRI_2839Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (260 aa)
SPRI_5263Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (302 aa)
SPRI_5186Membrane protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (277 aa)
SPRI_6478ABC transporter; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (543 aa)
hpfRibosomal subunit interface protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (230 aa)
SPRI_7309Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (591 aa)
SPRI_6902Peptide chain release factor 1; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (374 aa)
fusAElongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (697 aa)
infBTranslation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (613 aa)
tsfElongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (278 aa)
prfAPeptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa)
SPRI_2768GTP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (635 aa)
prfBPeptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (352 aa)
tuf-2Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (389 aa)
lepAElongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (620 aa)
rsfSIojap superfamily protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (166 aa)
SPRI_4839ABC transporter ATP-binding protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (554 aa)
SPRI_4095Peptide chain release factor 1; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (144 aa)
SPRI_4229Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (654 aa)
SPRI_4851Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (447 aa)
SPRI_6627Hypothetical protein; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (138 aa)
SPRI_6257IMPACT family member yvyE; Derived by Prodigal V2.6.2 analysis using gene prediction method: Protein Homology. (208 aa)
fusA-2Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (708 aa)
tufElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (397 aa)
efpElongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (188 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (242 aa)
Your Current Organism:
Streptomyces pristinaespiralis
NCBI taxonomy Id: 38300
Other names: S. pristinaespiralis
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