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mdh mdh Rcas_0581 Rcas_0581 Rcas_0881 Rcas_0881 Rcas_0909 Rcas_0909 Rcas_0910 Rcas_0910 Rcas_0925 Rcas_0925 Rcas_1241 Rcas_1241 Rcas_1242 Rcas_1242 Rcas_1531 Rcas_1531 Rcas_1532 Rcas_1532 Rcas_1946 Rcas_1946 Rcas_2308 Rcas_2308 Rcas_2309 Rcas_2309 Rcas_2482 Rcas_2482 Rcas_2490 Rcas_2490 Rcas_3079 Rcas_3079 Rcas_3080 Rcas_3080 Rcas_3081 Rcas_3081 sucC sucC Rcas_3315 Rcas_3315 Rcas_3529 Rcas_3529 Rcas_3575 Rcas_3575 Rcas_3576 Rcas_3576 Rcas_3577 Rcas_3577 Rcas_3578 Rcas_3578 sucD sucD Rcas_4052 Rcas_4052
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (309 aa)
Rcas_0581KEGG: rrs:RoseRS_3488 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family. (428 aa)
Rcas_0881Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (918 aa)
Rcas_0909PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: rrs:RoseRS_4176 L-carnitine dehydratase/bile acid-inducible protein F; Belongs to the CoA-transferase III family. (479 aa)
Rcas_0910PFAM: L-carnitine dehydratase/bile acid-inducible protein F; KEGG: rrs:RoseRS_4175 L-carnitine dehydratase/bile acid-inducible protein F; Belongs to the CoA-transferase III family. (405 aa)
Rcas_0925PFAM: fumarate lyase; KEGG: rrs:RoseRS_3341 fumarate lyase. (484 aa)
Rcas_1241TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_0785 isocitrate dehydrogenase, NADP-dependent. (454 aa)
Rcas_1242PFAM: CBS domain containing protein; KEGG: rrs:RoseRS_0784 putative signal-transduction protein with CBS domains. (213 aa)
Rcas_15312-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
Rcas_1532KEGG: rrs:RoseRS_3396 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region. (953 aa)
Rcas_1946Transketolase central region; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (795 aa)
Rcas_2308PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rrs:RoseRS_1551 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (615 aa)
Rcas_2309PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rrs:RoseRS_1552 thiamine pyrophosphate enzyme domain protein TPP-binding. (348 aa)
Rcas_2482KEGG: rrs:RoseRS_1064 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; Belongs to the PEP-utilizing enzyme family. (889 aa)
Rcas_2490Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic protein domain protein; malic protein NAD-binding; KEGG: rrs:RoseRS_2286 malate dehydrogenase (oxaloacetate-decarboxylating). (473 aa)
Rcas_3079TIGRFAM: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; KEGG: rrs:RoseRS_2400 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family. (226 aa)
Rcas_3080KEGG: rrs:RoseRS_2399 succinate dehydrogenase or fumarate reductase, flavoprotein subunit; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase. (656 aa)
Rcas_3081TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: rrs:RoseRS_2398 succinate dehydrogenase and fumarate reductase iron-sulfur protein. (249 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (379 aa)
Rcas_3315PFAM: phosphate acetyl/butaryl transferase; MaoC domain protein dehydratase; KEGG: rrs:RoseRS_3886 phosphate butyryltransferase. (470 aa)
Rcas_3529PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: rrs:RoseRS_3704 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). (568 aa)
Rcas_3575PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: rrs:RoseRS_1368 pyruvate ferredoxin/flavodoxin oxidoreductase. (183 aa)
Rcas_3576PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rrs:RoseRS_1369 thiamine pyrophosphate enzyme domain protein TPP-binding. (249 aa)
Rcas_3577PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: rrs:RoseRS_1370 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (367 aa)
Rcas_3578PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: rrs:RoseRS_1371 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (90 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
Rcas_4052PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rrs:RoseRS_1213 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (1192 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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