STRINGSTRING
Rcas_2468 Rcas_2468 Rcas_1609 Rcas_1609 mfd mfd ruvA ruvA Rcas_1024 Rcas_1024 Rcas_1010 Rcas_1010 Rcas_0944 Rcas_0944 recG recG Rcas_0389 Rcas_0389 rho rho uvrB uvrB Rcas_3376 Rcas_3376 Rcas_3301 Rcas_3301 Rcas_3862 Rcas_3862 ruvB ruvB Rcas_2984 Rcas_2984 priA priA Rcas_3990 Rcas_3990 Rcas_3875 Rcas_3875
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rcas_2468ATP-dependent DNA helicase, RecQ family; KEGG: ana:alr3451 ATP-dependent DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases. (708 aa)
Rcas_1609PFAM: SNF2-related protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicases; KEGG: rrs:RoseRS_0240 helicase domain protein. (1129 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1246 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
Rcas_1024PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; DEAD/H associated domain protein; SMART: DEAD-like helicases; KEGG: rrs:RoseRS_3430 DEAD/H associated domain protein. (833 aa)
Rcas_1010CRISPR-associated helicase Cas3; KEGG: afu:AF0071 ATP-dependent RNA helicase, putative; TIGRFAM: CRISPR-associated helicase Cas3; PFAM: DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases. (859 aa)
Rcas_0944PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases; KEGG: rrs:RoseRS_3701 DEAD/DEAH box helicase domain protein. (450 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (842 aa)
Rcas_0389PFAM: UvrD/REP helicase; KEGG: rrs:RoseRS_0142 UvrD/REP helicase. (759 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (445 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (670 aa)
Rcas_3376PFAM: UvrD/REP helicase; KEGG: rrs:RoseRS_2224 UvrD/REP helicase. (659 aa)
Rcas_3301KEGG: rrs:RoseRS_1868 CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases. (779 aa)
Rcas_3862PFAM: NERD domain protein; KEGG: rrs:RoseRS_1932 hypothetical protein. (466 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (347 aa)
Rcas_2984Helicase superfamily 1 and 2 ATP-binding; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases; KEGG: rrs:RoseRS_2921 DEAD/DEAH box helicase domain protein. (862 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (866 aa)
Rcas_3990Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (444 aa)
Rcas_3875KEGG: rrs:RoseRS_0167 nuclease (RecB family)-like protein. (499 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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