STRINGSTRING
Rcas_2468 Rcas_2468 Rcas_0044 Rcas_0044 xerC xerC Rcas_0361 Rcas_0361 Rcas_0405 Rcas_0405 Rcas_0411 Rcas_0411 recG recG Rcas_0616 Rcas_0616 Rcas_0673 Rcas_0673 ruvC ruvC Rcas_0882 Rcas_0882 ruvA ruvA Rcas_1148 Rcas_1148 Rcas_1289 Rcas_1289 sbcD sbcD Rcas_1468 Rcas_1468 recO recO Rcas_1708 Rcas_1708 radA radA Rcas_2076 Rcas_2076 recR recR Rcas_2775 Rcas_2775 Rcas_2866 Rcas_2866 recA recA ruvB ruvB Rcas_3185 Rcas_3185 Rcas_3401 Rcas_3401 Rcas_3449 Rcas_3449 Rcas_3464 Rcas_3464 Rcas_3561 Rcas_3561 Rcas_3651 Rcas_3651 Rcas_3702 Rcas_3702 Rcas_3931 Rcas_3931 Rcas_4064 Rcas_4064 Rcas_4223 Rcas_4223 Rcas_4244 Rcas_4244 Rcas_4396 Rcas_4396
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rcas_2468ATP-dependent DNA helicase, RecQ family; KEGG: ana:alr3451 ATP-dependent DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; PFAM: helicase domain protein; type III restriction protein res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases. (708 aa)
Rcas_0044PFAM: integrase family protein; KEGG: rrs:RoseRS_0860 phage integrase family protein. (337 aa)
xerCIntegrase family protein; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (314 aa)
Rcas_0361DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (601 aa)
Rcas_0405PFAM: transposase IS4 family protein; KEGG: rrs:RoseRS_0444 transposase, IS4 family protein. (383 aa)
Rcas_0411PFAM: transposase IS4 family protein; KEGG: rrs:RoseRS_0444 transposase, IS4 family protein. (383 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (842 aa)
Rcas_0616PFAM: integrase family protein; KEGG: rrs:RoseRS_0840 integron integrase. (229 aa)
Rcas_0673Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (92 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (168 aa)
Rcas_0882PFAM: DNA polymerase beta domain protein region; KEGG: gme:Gmet_3257 DNA polymerase, beta-like region. (156 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
Rcas_1148KEGG: rrs:RoseRS_0396 hypothetical protein. (556 aa)
Rcas_1289KEGG: sru:SRU_2010 putative transposase, orfB. (115 aa)
sbcDNuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (418 aa)
Rcas_1468PFAM: transposase IS200-family protein; KEGG: rrs:RoseRS_0733 transposase IS200-family protein. (137 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (266 aa)
Rcas_1708PFAM: transposase IS4 family protein; KEGG: rrs:RoseRS_1382 transposase, IS4 family protein. (273 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (464 aa)
Rcas_2076KEGG: mma:MM3038 transposase; TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB. (380 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (205 aa)
Rcas_2775KEGG: ppd:Ppro_2335 hypothetical protein. (129 aa)
Rcas_2866TIGRFAM: integron integrase; PFAM: integrase family protein; KEGG: tbd:Tbd_1215 integron integrase; Belongs to the 'phage' integrase family. (276 aa)
recArecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (353 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (347 aa)
Rcas_3185KEGG: rrs:RoseRS_3081 hypothetical protein. (638 aa)
Rcas_3401Hypothetical protein. (95 aa)
Rcas_3449PFAM: ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: rrs:RoseRS_1583 ATP dependent DNA ligase. (544 aa)
Rcas_3464Hypothetical protein; KEGG: mlo:mlr9643 transposase. (159 aa)
Rcas_3561PFAM: transposase IS4 family protein; KEGG: fra:Francci3_4220 transposase, IS4. (360 aa)
Rcas_3651Transposase, IS605 OrfB family; KEGG: noc:Noc_0388 transposase (probable), IS891/IS1136/IS1341; TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase IS891/IS1136/IS1341 family; transposase IS605 OrfB. (380 aa)
Rcas_3702PFAM: protein of unknown function DUF1568; KEGG: sus:Acid_5308 protein of unknown function DUF1568. (208 aa)
Rcas_3931TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; KEGG: rrs:RoseRS_2008 single-stranded-DNA-specific exonuclease RecJ. (572 aa)
Rcas_4064PFAM: transposase IS4 family protein; KEGG: pcu:pc1688 hypothetical protein. (278 aa)
Rcas_4223PFAM: protein of unknown function DUF1568; KEGG: rba:RB693 hypothetical protein. (212 aa)
Rcas_4244KEGG: rrs:RoseRS_2592 hypothetical protein. (538 aa)
Rcas_4396TIGRFAM: integron integrase; PFAM: integrase family protein; KEGG: mfa:Mfla_0410 integron integrase; Belongs to the 'phage' integrase family. (318 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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