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ruvA ruvA Rcas_1002 Rcas_1002 smc smc Rcas_0691 Rcas_0691 recG recG Rcas_0389 Rcas_0389 gyrA gyrA priA priA cas2-2 cas2-2 cas2 cas2 cas1 cas1 Rcas_1931 Rcas_1931 Rcas_1748 Rcas_1748 topA topA Rcas_1650 Rcas_1650 Rcas_1609 Rcas_1609 Rcas_1607 Rcas_1607 mfd mfd Rcas_1135 Rcas_1135 gyrB gyrB mtaD mtaD Rcas_3990 Rcas_3990 cas2-3 cas2-3 Rcas_3328 Rcas_3328 Rcas_3376 Rcas_3376 Rcas_3862 Rcas_3862 Rcas_3875 Rcas_3875 cas1-3 cas1-3 Rcas_3240 Rcas_3240 Rcas_3183 Rcas_3183 ruvB ruvB Rcas_3019 Rcas_3019 Rcas_3018 Rcas_3018 Rcas_2984 Rcas_2984 Rcas_2921 Rcas_2921 Rcas_2742 Rcas_2742 cas1-2 cas1-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
Rcas_1002PFAM: NERD domain protein; DNA topoisomerase type IA zn finger domain protein; KEGG: tte:TTE0673 hypothetical protein. (281 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1200 aa)
Rcas_0691PFAM: protein of unknown function DUF87; KEGG: sth:STH2259 hypothetical protein. (700 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (842 aa)
Rcas_0389PFAM: UvrD/REP helicase; KEGG: rrs:RoseRS_0142 UvrD/REP helicase. (759 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (823 aa)
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (866 aa)
cas2-2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (91 aa)
cas2CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (93 aa)
cas1CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (339 aa)
Rcas_1931KEGG: rrs:RoseRS_2968 hypothetical protein. (595 aa)
Rcas_1748SMART: AAA ATPase; KEGG: rrs:RoseRS_2121 AAA ATPase. (432 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (836 aa)
Rcas_1650KEGG: rrs:RoseRS_1294 hypothetical protein. (216 aa)
Rcas_1609PFAM: SNF2-related protein; helicase domain protein; type III restriction protein res subunit; SMART: DEAD-like helicases; KEGG: rrs:RoseRS_0240 helicase domain protein. (1129 aa)
Rcas_1607KEGG: rrs:RoseRS_1734 SMC domain protein. (909 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1246 aa)
Rcas_1135KEGG: rrs:RoseRS_3748 Mg chelatase, subunit ChlI; TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase. (505 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (653 aa)
mtaDAmidohydrolase; Catalyzes the deamination of 5-methylthioadenosine and S- adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine. Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family. (663 aa)
Rcas_3990Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (444 aa)
cas2-3CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (85 aa)
Rcas_3328KEGG: rrs:RoseRS_3980 non-specific serine/threonine protein kinase; PFAM: SNF2-related protein; helicase domain protein; SMART: DEAD-like helicases. (1066 aa)
Rcas_3376PFAM: UvrD/REP helicase; KEGG: rrs:RoseRS_2224 UvrD/REP helicase. (659 aa)
Rcas_3862PFAM: NERD domain protein; KEGG: rrs:RoseRS_1932 hypothetical protein. (466 aa)
Rcas_3875KEGG: rrs:RoseRS_0167 nuclease (RecB family)-like protein. (499 aa)
cas1-3CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (338 aa)
Rcas_3240PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: rrs:RoseRS_1877 AAA ATPase, central domain protein. (459 aa)
Rcas_3183PFAM: protein of unknown function DUF87; KEGG: rrs:RoseRS_1701 protein of unknown function DUF87. (538 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (347 aa)
Rcas_3019KEGG: rrs:RoseRS_2042 hypothetical protein. (319 aa)
Rcas_3018KEGG: rrs:RoseRS_2041 hypothetical protein. (390 aa)
Rcas_2984Helicase superfamily 1 and 2 ATP-binding; PFAM: helicase domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases; KEGG: rrs:RoseRS_2921 DEAD/DEAH box helicase domain protein. (862 aa)
Rcas_2921KEGG: rrs:RoseRS_3193 hypothetical protein. (368 aa)
Rcas_2742AAA ATPase; KEGG: rrs:RoseRS_2674 AAA ATPase. (538 aa)
cas1-2CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (332 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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