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gcvPB gcvPB uvrA-2 uvrA-2 Rcas_4386 Rcas_4386 Rcas_4275 Rcas_4275 Rcas_4254 Rcas_4254 Rcas_4197 Rcas_4197 Rcas_4111 Rcas_4111 Rcas_4102 Rcas_4102 Rcas_4094 Rcas_4094 Rcas_4041 Rcas_4041 Rcas_4040 Rcas_4040 rpoA rpoA Rcas_3862 Rcas_3862 hypA hypA Rcas_3806 Rcas_3806 Rcas_3795 Rcas_3795 Rcas_3780 Rcas_3780 sucD sucD pdxT pdxT Rcas_3611 Rcas_3611 Rcas_3578 Rcas_3578 ppk ppk uvrB uvrB leuD-3 leuD-3 leuD-2 leuD-2 Rcas_3412 Rcas_3412 Rcas_3391 Rcas_3391 Rcas_3389 Rcas_3389 carA carA Rcas_3244 Rcas_3244 Rcas_3192 Rcas_3192 Rcas_3148 Rcas_3148 ruvB ruvB uvrC uvrC accA-2 accA-2 accD2 accD2 xseB xseB xseA xseA Rcas_2899 Rcas_2899 Rcas_2881 Rcas_2881 Rcas_2804 Rcas_2804 Rcas_2740 Rcas_2740 Rcas_2736 Rcas_2736 Rcas_2644 Rcas_2644 Rcas_2516 Rcas_2516 Rcas_2493 Rcas_2493 Rcas_2335 Rcas_2335 dnaX dnaX gcvH gcvH gcvPA gcvPA Rcas_2170 Rcas_2170 Rcas_2021 Rcas_2021 Rcas_2011 Rcas_2011 Rcas_1946 Rcas_1946 Rcas_1847 Rcas_1847 rpoB rpoB rpoC rpoC leuD leuD Rcas_1532 Rcas_1532 Rcas_1531 Rcas_1531 clpX clpX rnpA rnpA Rcas_1365 Rcas_1365 Rcas_1364 Rcas_1364 Rcas_1320 Rcas_1320 accD1 accD1 accA accA ruvA ruvA Rcas_0975 Rcas_0975 Rcas_0950 Rcas_0950 Rcas_0921 Rcas_0921 Rcas_0912 Rcas_0912 Rcas_0820 Rcas_0820 Rcas_0749 Rcas_0749 cobQ cobQ uvrA uvrA Rcas_0442 Rcas_0442 dnaG dnaG eno eno
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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gcvPBGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (518 aa)
uvrA-2Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1043 aa)
Rcas_4386TIGRFAM: oxidoreductase alpha (molybdopterin) subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; KEGG: rrs:RoseRS_4018 oxidoreductase alpha (molybdopterin) subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (742 aa)
Rcas_4275TIGRFAM: DNA polymerase III, delta prime subunit; KEGG: rrs:RoseRS_3588 DNA polymerase III, delta prime subunit. (354 aa)
Rcas_4254KEGG: rrs:RoseRS_0006 hypothetical protein. (243 aa)
Rcas_4197PFAM: ATPase associated with various cellular activities AAA_5; KEGG: rrs:RoseRS_0045 GTPase subunit of restriction endonuclease-like protein. (578 aa)
Rcas_4111PFAM: FAD dependent oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: rrs:RoseRS_3299 FAD dependent oxidoreductase. (556 aa)
Rcas_4102PFAM: carboxyl transferase; KEGG: rrs:RoseRS_3291 carboxyl transferase. (516 aa)
Rcas_4094KEGG: rrs:RoseRS_0906 biotin carboxylase-like protein. (389 aa)
Rcas_4041KEGG: rrs:RoseRS_1199 nitrogenase component I, alpha chain; TIGRFAM: nitrogenase alpha chain; nitrogenase component I, alpha chain; PFAM: oxidoreductase/nitrogenase component 1; Belongs to the NifD/NifK/NifE/NifN family. (476 aa)
Rcas_4040Nitrogenase; PFAM: oxidoreductase/nitrogenase component 1; KEGG: rrs:RoseRS_1198 nitrogenase. (475 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (323 aa)
Rcas_3862PFAM: NERD domain protein; KEGG: rrs:RoseRS_1932 hypothetical protein. (466 aa)
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (138 aa)
Rcas_3806PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: fra:Francci3_1077 hydrogenase (NiFe) small subunit (HydA). (323 aa)
Rcas_3795TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: rrs:RoseRS_0975 hydrogenase expression/formation protein HypE. (352 aa)
Rcas_3780PFAM: ribonucleotide reductase; KEGG: rrs:RoseRS_1973 ribonucleotide reductase. (295 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
pdxTSNO glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (189 aa)
Rcas_3611PFAM: Amylo-alpha-16-glucosidase; KEGG: rrs:RoseRS_3939 amylo-alpha-1,6-glucosidase. (723 aa)
Rcas_3578PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: rrs:RoseRS_1371 4Fe-4S ferredoxin, iron-sulfur binding domain protein. (90 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (708 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (670 aa)
leuD-33-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (170 aa)
leuD-23-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (166 aa)
Rcas_3412Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (411 aa)
Rcas_3391NADH-quinone oxidoreductase, F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (451 aa)
Rcas_3389NADH-quinone oxidoreductase, chain G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (923 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: rrs:RoseRS_4055 carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family. (386 aa)
Rcas_3244PFAM: glycoside hydrolase family 2 sugar binding; KEGG: rrs:RoseRS_0991 glycoside hydrolase family 2, sugar binding. (916 aa)
Rcas_3192TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: rrs:RoseRS_3075 DNA polymerase III, delta subunit. (354 aa)
Rcas_3148KEGG: rrs:RoseRS_2319 hydrogenase (NiFe) small subunit HydA; TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; Nickel-iron dehydrogenase small subunit domain protein. (417 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (347 aa)
uvrCExcinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (665 aa)
accA-2acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (276 aa)
accD2acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (328 aa)
xseBExonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
xseAExodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (393 aa)
Rcas_2899acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (182 aa)
Rcas_2881PFAM: carboxyl transferase; KEGG: rrs:RoseRS_2907 propionyl-CoA carboxylase. (514 aa)
Rcas_2804PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: rrs:RoseRS_1675 catalytic domain of components of various dehydrogenase complexes. (445 aa)
Rcas_2740PFAM: NADH-ubiquinone oxidoreductase chain 49kDa; KEGG: rrs:RoseRS_2672 NADH-ubiquinone oxidoreductase, chain 49kDa. (358 aa)
Rcas_2736PFAM: NADH ubiquinone oxidoreductase 20 kDa subunit; KEGG: rrs:RoseRS_2668 NADH ubiquinone oxidoreductase, 20 kDa subunit. (125 aa)
Rcas_2644Beta-mannosidase; PFAM: glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2 sugar binding; KEGG: rrs:RoseRS_1576 beta-mannosidase. (833 aa)
Rcas_2516KEGG: rrs:RoseRS_1828 glycogen debranching enzyme-like protein. (445 aa)
Rcas_2493Beta-galactosidase; PFAM: glycoside hydrolase family 42 domain 5 loop region; glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2 TIM barrel; glycoside hydrolase family 2 sugar binding; KEGG: rrs:RoseRS_2714 beta-galactosidase. (1043 aa)
Rcas_2335PFAM: NAD/NADP octopine/nopaline dehydrogenase; NADP oxidoreductase coenzyme F420-dependent; 6-phosphogluconate dehydrogenase NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein; Ketopantoate reductase ApbA/PanE domain protein; KEGG: rrs:RoseRS_2460 NAD/NADP octopine/nopaline dehydrogenase. (368 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (644 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvPAGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (445 aa)
Rcas_2170PFAM: Amylo-alpha-16-glucosidase; KEGG: rrs:RoseRS_1790 amylo-alpha-1,6-glucosidase. (676 aa)
Rcas_2021PFAM: glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2 TIM barrel; glycoside hydrolase family 2 sugar binding; KEGG: rrs:RoseRS_1740 glycoside hydrolase family 2, sugar binding. (724 aa)
Rcas_2011Dihydrolipoyllysine-residue succinyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: rrs:RoseRS_1726 dihydrolipoyllysine-residue succinyltransferase. (454 aa)
Rcas_1946Transketolase central region; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (795 aa)
Rcas_1847TIGRFAM: [NiFe] hydrogenase maturation protein HypF; PFAM: acylphosphatase; SUA5/yciO/yrdC domain; zinc finger HypF domain protein; KEGG: rrs:RoseRS_2556 (NiFe) hydrogenase maturation protein HypF. (779 aa)
rpoBDNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1245 aa)
rpoCDNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1502 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (204 aa)
Rcas_1532KEGG: rrs:RoseRS_3396 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region. (953 aa)
Rcas_15312-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (436 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (122 aa)
Rcas_1365PFAM: Respiratory-chain NADH dehydrogenase domain 51 kDa subunit; KEGG: rrs:RoseRS_3542 NADH dehydrogenase (quinone). (532 aa)
Rcas_1364PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: rrs:RoseRS_3543 NADH dehydrogenase (ubiquinone), 24 kDa subunit. (173 aa)
Rcas_1320TIGRFAM: NADH-quinone oxidoreductase, E subunit; PFAM: NADH dehydrogenase (ubiquinone) 24 kDa subunit; KEGG: rrs:RoseRS_3674 NADH-quinone oxidoreductase, E subunit. (174 aa)
accD1acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (287 aa)
ruvAHolliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa)
Rcas_0975Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: rrs:RoseRS_3827 propionyl-CoA carboxylase. (535 aa)
Rcas_0950PFAM: carboxyl transferase; KEGG: rrs:RoseRS_3695 carboxyl transferase. (514 aa)
Rcas_0921PFAM: alpha-L-rhamnosidase; KEGG: sus:Acid_3742 alpha-L-rhamnosidase. (775 aa)
Rcas_0912PFAM: HpcH/HpaI aldolase; KEGG: rrs:RoseRS_4173 HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family. (347 aa)
Rcas_0820PFAM: iron permease FTR1; KEGG: rrs:RoseRS_4468 iron permease FTR1. (782 aa)
Rcas_0749DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (377 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (490 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (976 aa)
Rcas_0442KEGG: rrs:RoseRS_4212 hypothetical protein. (762 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (652 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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