STRINGSTRING
eno eno Rcas_0076 Rcas_0076 Rcas_0272 Rcas_0272 gpmI gpmI Rcas_0678 Rcas_0678 pgi pgi Rcas_0924 Rcas_0924 tpiA tpiA Rcas_1157 Rcas_1157 Rcas_1213 Rcas_1213 Rcas_1385 Rcas_1385 Rcas_1692 Rcas_1692 Rcas_1875 Rcas_1875 Rcas_1946 Rcas_1946 Rcas_2011 Rcas_2011 Rcas_2012 Rcas_2012 pdhA pdhA pgk pgk Rcas_2104 Rcas_2104 Rcas_2308 Rcas_2308 Rcas_2309 Rcas_2309 Rcas_2314 Rcas_2314 Rcas_2390 Rcas_2390 Rcas_2482 Rcas_2482 Rcas_2513 Rcas_2513 pfkA pfkA Rcas_2754 Rcas_2754 pckG pckG Rcas_2897 Rcas_2897 fbp fbp Rcas_3154 Rcas_3154 Rcas_3224 Rcas_3224 Rcas_3283 Rcas_3283 Rcas_3330 Rcas_3330 Rcas_3576 Rcas_3576 Rcas_3577 Rcas_3577 Rcas_3934 Rcas_3934 Rcas_3935 Rcas_3935 Rcas_4052 Rcas_4052 Rcas_4434 Rcas_4434
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
Rcas_0076TIGRFAM: Acetyl coenzyme A synthetase (ADP forming) alpha domain; PFAM: CoA-binding domain protein; KEGG: rrs:RoseRS_4534 CoA-binding domain protein. (698 aa)
Rcas_0272PFAM: aldehyde dehydrogenase; KEGG: rrs:RoseRS_0265 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. (517 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (524 aa)
Rcas_0678PFAM: ROK family protein; KEGG: rrs:RoseRS_0099 ROK family protein. (324 aa)
pgiPFAM: phosphoglucose isomerase (PGI); KEGG: rrs:RoseRS_4356 glucose-6-phosphate isomerase; Belongs to the GPI family. (543 aa)
Rcas_0924TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: rrs:RoseRS_4187 fructose-1,6-bisphosphatase, class II; Belongs to the FBPase class 2 family. (333 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
Rcas_1157PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: rrs:RoseRS_0387 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
Rcas_1213TIGRFAM: fructose-1,6-bisphosphatase, class II; PFAM: GlpX family protein; KEGG: rrs:RoseRS_4129 fructose-1,6-bisphosphatase, class II. (329 aa)
Rcas_1385PFAM: glycoside hydrolase family 4; KEGG: rrs:RoseRS_4113 glycoside hydrolase, family 4. (424 aa)
Rcas_1692KEGG: rrs:RoseRS_1428 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (479 aa)
Rcas_18756-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (744 aa)
Rcas_1946Transketolase central region; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (795 aa)
Rcas_2011Dihydrolipoyllysine-residue succinyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: rrs:RoseRS_1726 dihydrolipoyllysine-residue succinyltransferase. (454 aa)
Rcas_2012Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (322 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (353 aa)
pgkPFAM: phosphoglycerate kinase; KEGG: rrs:RoseRS_1473 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
Rcas_2104TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: rrs:RoseRS_3003 dihydrolipoamide dehydrogenase. (471 aa)
Rcas_2308PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rrs:RoseRS_1551 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (615 aa)
Rcas_2309PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rrs:RoseRS_1552 thiamine pyrophosphate enzyme domain protein TPP-binding. (348 aa)
Rcas_2314KEGG: rrs:RoseRS_1226 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
Rcas_2390PFAM: ROK family protein; KEGG: rrs:RoseRS_2764 ROK family protein. (348 aa)
Rcas_2482KEGG: rrs:RoseRS_1064 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; Belongs to the PEP-utilizing enzyme family. (889 aa)
Rcas_25136-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (385 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (372 aa)
Rcas_2754PFAM: ROK family protein; KEGG: rrs:RoseRS_2512 ROK family protein. (332 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (619 aa)
Rcas_2897PFAM: ROK family protein; KEGG: rrs:RoseRS_3170 ROK family protein. (312 aa)
fbpProtein of unknown function DUF100; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (379 aa)
Rcas_3154Aldose 1-epimerase; Converts alpha-aldose to the beta-anomer. (350 aa)
Rcas_3224PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: rrs:RoseRS_3921 alcohol dehydrogenase GroES domain protein. (317 aa)
Rcas_3283KEGG: rrs:RoseRS_1851 glyceraldehyde-3-phosphate dehydrogenase, type I; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (347 aa)
Rcas_3330PFAM: Phosphoglycerate mutase; KEGG: rrs:RoseRS_1012 phosphoglycerate mutase. (175 aa)
Rcas_3576PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rrs:RoseRS_1369 thiamine pyrophosphate enzyme domain protein TPP-binding. (249 aa)
Rcas_3577PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: rrs:RoseRS_1370 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (367 aa)
Rcas_3934acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (639 aa)
Rcas_3935acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (650 aa)
Rcas_4052PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rrs:RoseRS_1213 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (1192 aa)
Rcas_4434PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: rrs:RoseRS_0752 alcohol dehydrogenase GroES domain protein. (341 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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