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Rcas_0076 Rcas_0076 Rcas_0240 Rcas_0240 Rcas_0272 Rcas_0272 mdh mdh Rcas_0702 Rcas_0702 Rcas_0709 Rcas_0709 Rcas_0925 Rcas_0925 Rcas_0953 Rcas_0953 Rcas_0983 Rcas_0983 accA accA accD1 accD1 Rcas_1551 Rcas_1551 leuA leuA Rcas_1692 Rcas_1692 Rcas_1819 Rcas_1819 Rcas_1946 Rcas_1946 Rcas_2011 Rcas_2011 Rcas_2012 Rcas_2012 pdhA pdhA Rcas_2104 Rcas_2104 Rcas_2308 Rcas_2308 Rcas_2309 Rcas_2309 ppc ppc Rcas_2411 Rcas_2411 Rcas_2482 Rcas_2482 Rcas_2490 Rcas_2490 Rcas_2707 Rcas_2707 pckG pckG Rcas_2882 Rcas_2882 Rcas_2899 Rcas_2899 accD2 accD2 accA-2 accA-2 Rcas_2931 Rcas_2931 Rcas_2954 Rcas_2954 Rcas_2955 Rcas_2955 Rcas_2967 Rcas_2967 Rcas_3206 Rcas_3206 Rcas_3429 Rcas_3429 Rcas_3529 Rcas_3529 Rcas_3576 Rcas_3576 Rcas_3577 Rcas_3577 Rcas_3632 Rcas_3632 Rcas_3934 Rcas_3934 Rcas_3935 Rcas_3935 Rcas_4052 Rcas_4052 Rcas_4290 Rcas_4290 Rcas_4376 Rcas_4376
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Rcas_0076TIGRFAM: Acetyl coenzyme A synthetase (ADP forming) alpha domain; PFAM: CoA-binding domain protein; KEGG: rrs:RoseRS_4534 CoA-binding domain protein. (698 aa)
Rcas_0240PFAM: acylphosphatase; KEGG: rrs:RoseRS_0311 acylphosphatase. (93 aa)
Rcas_0272PFAM: aldehyde dehydrogenase; KEGG: rrs:RoseRS_0265 aldehyde dehydrogenase (NAD(+)); Belongs to the aldehyde dehydrogenase family. (517 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (309 aa)
Rcas_0702KEGG: rrs:RoseRS_4348 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
Rcas_0709PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: rrs:RoseRS_4355 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding. (331 aa)
Rcas_0925PFAM: fumarate lyase; KEGG: rrs:RoseRS_3341 fumarate lyase. (484 aa)
Rcas_0953KEGG: rrs:RoseRS_3692 sodium ion-translocating decarboxylase, beta subunit; TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+transporting methylmalonyl-CoA/oxaloacetate decarboxylase beta subunit. (376 aa)
Rcas_0983KEGG: rrs:RoseRS_0429 acetyl-CoA acetyltransferase-like protein. (384 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (287 aa)
accD1acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (298 aa)
Rcas_1551TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain; KEGG: rrs:RoseRS_1963 2-isopropylmalate synthase/homocitrate synthase family protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (536 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (556 aa)
Rcas_1692KEGG: rrs:RoseRS_1428 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family. (479 aa)
Rcas_1819PFAM: beta-lactamase domain protein; KEGG: rrs:RoseRS_2738 beta-lactamase domain protein. (204 aa)
Rcas_1946Transketolase central region; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (795 aa)
Rcas_2011Dihydrolipoyllysine-residue succinyltransferase; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: rrs:RoseRS_1726 dihydrolipoyllysine-residue succinyltransferase. (454 aa)
Rcas_2012Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (322 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (353 aa)
Rcas_2104TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase; KEGG: rrs:RoseRS_3003 dihydrolipoamide dehydrogenase. (471 aa)
Rcas_2308PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rrs:RoseRS_1551 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (615 aa)
Rcas_2309PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rrs:RoseRS_1552 thiamine pyrophosphate enzyme domain protein TPP-binding. (348 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (938 aa)
Rcas_2411Acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (305 aa)
Rcas_2482KEGG: rrs:RoseRS_1064 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; Belongs to the PEP-utilizing enzyme family. (889 aa)
Rcas_2490Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic protein domain protein; malic protein NAD-binding; KEGG: rrs:RoseRS_2286 malate dehydrogenase (oxaloacetate-decarboxylating). (473 aa)
Rcas_2707KEGG: rrs:RoseRS_3215 hypothetical protein. (421 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (619 aa)
Rcas_2882Carbamoyl-phosphate synthase L chain ATP-binding; PFAM: ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: rrs:RoseRS_2908 biotin carboxylase domain protein. (493 aa)
Rcas_2899acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (182 aa)
accD2acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (328 aa)
accA-2acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (276 aa)
Rcas_2931acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
Rcas_2954PFAM: biotin/lipoyl attachment domain-containing protein; pyruvate carboxyltransferase; KEGG: cph:Cpha266_1063 biotin/lipoyl attachment domain-containing protein. (685 aa)
Rcas_2955PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: cph:Cpha266_1064 carbamoyl-phosphate synthase L chain, ATP-binding. (484 aa)
Rcas_2967Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (910 aa)
Rcas_3206KEGG: rrs:RoseRS_3911 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Rcas_3429D-lactate dehydrogenase (cytochrome); PFAM: FAD linked oxidase domain protein; KEGG: rrs:RoseRS_1612 D-lactate dehydrogenase (cytochrome). (887 aa)
Rcas_3529PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: rrs:RoseRS_3704 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)). (568 aa)
Rcas_3576PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: rrs:RoseRS_1369 thiamine pyrophosphate enzyme domain protein TPP-binding. (249 aa)
Rcas_3577PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; Transketolase domain protein; KEGG: rrs:RoseRS_1370 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (367 aa)
Rcas_3632PFAM: beta-lactamase domain protein; SMART: Rhodanese domain protein; KEGG: rrs:RoseRS_3957 beta-lactamase domain protein. (488 aa)
Rcas_3934acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (639 aa)
Rcas_3935acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (650 aa)
Rcas_4052PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rrs:RoseRS_1213 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein. (1192 aa)
Rcas_4290acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (591 aa)
Rcas_4376KEGG: rrs:RoseRS_4165 malate synthase A; TIGRFAM: malate synthase A; PFAM: malate synthase. (523 aa)
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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