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| | aroE | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa) |
| | trpA | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | trpB | Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa) |
| | thrB | Homoserine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pseudomonas-type ThrB family. (316 aa) |
| | PSEEN0075 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (96 aa) |
| | srpH | Serine O-acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (310 aa) |
| | folA | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa) |
| | PSEEN0310 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (108 aa) |
| | PSEEN0311 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (386 aa) |
| | PSEEN0313 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (144 aa) |
| | metW | Methionine biosynthesis protein MetW; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (206 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (379 aa) |
| | PSEEN0316 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (196 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | PSEEN0318 | Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (228 aa) |
| | aroK | Shikimate-kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (365 aa) |
| | PSEEN0389 | Putative chorismate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (179 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (492 aa) |
| | trpG | Anthranilate synthase component II (Glutamine amido-transferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (197 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | trpC | Indole-3-glycerol phosphate synthase (IGPS); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpC family. (278 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (267 aa) |
| | glyA-1 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | cysE | Serine O-acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (261 aa) |
| | hisG | ATP-phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (211 aa) |
| | hisD | Histidinol dehydrogenase (also histidinol dehydrogenase activity); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Function of strongly homologous gene; enzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (348 aa) |
| | purU | Putative formyltetrahydrofolate deformylase PurU-2; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa) |
| | argG | Putative argininosuccinate synthase; Function of strongly homologous gene; enzyme; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | cysM | Cysteine synthase B (O-acetylserine sulfhydrolase B); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (299 aa) |
| | PSEEN1482 | Putative oxidoreductase, short chain dehydrogenase/reductase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (246 aa) |
| | PSEEN1483 | Putative phosphoglycolate phosphatase 2 (PGP 2); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (223 aa) |
| | PSEEN1485 | Putative chlorohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (437 aa) |
| | mtnA | Putative initiation factor 2 subunit family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (358 aa) |
| | serC | 3-phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | pheA | Bifunctional chorismate mutase/prephenate dehydratase PheA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (364 aa) |
| | aroA | Putative prephenate dehydrogenase, putative/3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (746 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | PSEEN1570 | Putative phospho-2-dehydro-3-deoxyheptonate aldolase, class II; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (448 aa) |
| | PSEEN1588 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (160 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa) |
| | PSEEN1687 | Putative aspartate semialdehyde deshydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the aspartate-semialdehyde dehydrogenase family. (334 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase (PRAI); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. (206 aa) |
| | folC | Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. (435 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa) |
| | arcB | Ornithine cyclodeaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (348 aa) |
| | folD | Bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | aro | Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa) |
| | PSEEN1897 | Putative para-aminodeoxychorismate synthase subunit I PabB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (447 aa) |
| | argC-2 | Putative N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (308 aa) |
| | PSEEN2008 | Putative L-serine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (305 aa) |
| | aroE-2 | Putative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (282 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | metY | O-acetylhomoserine sulfhydrylase; Function of strongly homologous gene; enzyme. (425 aa) |
| | PSEEN2380 | Putative dihydrodipicolinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the DapA family. (297 aa) |
| | PSEEN2446 | Putative serine O-acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (174 aa) |
| | sda-3 | L-serine deaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | PSEEN2474 | Putative 3-dehydroquinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (392 aa) |
| | pmsC | Isochorismate synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (389 aa) |
| | pmsA | Histidine decarboxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa) |
| | psmB | Isochorismate pyruvate-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (105 aa) |
| | PSEEN2579 | Hypothetical protein; No homology to any previously reported sequences. (98 aa) |
| | PSEEN2606 | Putative Arginase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the arginase family. (312 aa) |
| | PSEEN2650 | Putative N-acetylornithine deacetylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (386 aa) |
| | PSEEN2747 | Putative 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (342 aa) |
| | quiA | Quinate dehydrogenase (pyrroloquinoline-quinone); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (801 aa) |
| | ilvA-1 | Threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (520 aa) |
| | aroF-2 | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa) |
| | PSEEN3214 | Putative shikimate 5-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (273 aa) |
| | metH | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1235 aa) |
| | PSEEN3862 | Threonine synthase; Function of strongly homologous gene; enzyme. (414 aa) |
| | glyA-3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa) |
| | PSEEN3874 | Aspartate kinase, monofunctional class; Function of strongly homologous gene; enzyme; Belongs to the aspartokinase family. (411 aa) |
| | PSEEN3954 | Aminotransferase; Function of strongly homologous gene; enzyme. (400 aa) |
| | PSEEN3999 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (321 aa) |
| | cysK | Cysteine synthase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (324 aa) |
| | PSEEN4039 | Putative cystathionine gamma-synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (391 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | PSEEN4091 | Putative thioesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (150 aa) |
| | PSEEN4223 | Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (397 aa) |
| | dapD | Putative 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (344 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (383 aa) |
| | thrC | Threonine synthase; Function of strongly homologous gene; enzyme. (469 aa) |
| | hom | Homoserine dehydrogenase; Function of strongly homologous gene; enzyme. (450 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa) |
| | arcD-2 | Arginine/ornithine antiporter; Function of strongly homologous gene; transporter. (475 aa) |
| | arcD | Arginine/ornithine antiporter; Function of homologous gene experimentally demonstrated in an other organism; transporter. (475 aa) |
| | arcA | Arginine deiminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (418 aa) |
| | argF | Ornithine carbamoyltransferase, catabolic; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (336 aa) |
| | arcC | Carbamate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the carbamate kinase family. (309 aa) |
| | gcvH-2 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | gcvP-2 | Glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (951 aa) |
| | sdaA-2 | L-serine deaminase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | gcvT-2 | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. (373 aa) |
| | argJ | Glutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (405 aa) |
| | mdeA | Methionine gamma-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (398 aa) |
| | PSEEN4623 | Putative oxidoreductase, short-chain dehydrogenase/reductase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (230 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa) |
| | PSEEN4641 | Putative methylenetetrahydrofolate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (493 aa) |
| | PSEEN4679 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the multicopper oxidase YfiH/RL5 family. (245 aa) |
| | ubiC1 | Putative chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (185 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (423 aa) |
| | aroQ-1 | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | hisZ | Putative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (395 aa) |
| | serB | Phosphoserine phosphatase; Function of strongly homologous gene; enzyme. (415 aa) |
| | PSEEN5013 | Putative threonine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (325 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa) |
| | sahH | S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (469 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (281 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (130 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase; Function of strongly homologous gene; enzyme. (111 aa) |
| | pip | Proline iminopeptidase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the peptidase S33 family. (323 aa) |
| | PSEEN5110 | Putative acetylornithine aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (425 aa) |
| | purU-1 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa) |
| | soxG | Sarcosine oxidase, gamma subunit; Function of strongly homologous gene; enzyme. (210 aa) |
| | soxA | Sarcosine oxidase (alpha subunit) oxidoreductase protein; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. (1005 aa) |
| | soxD | Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme. (111 aa) |
| | soxB | Sarcosine oxidase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (416 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | ltaE | Low-specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa) |
| | PSEEN5168 | Putative oxidoreductase, FAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (366 aa) |
| | PSEEN5169 | Putative iron-sulfur cluster-binding protein, Rieske family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (430 aa) |
| | PSEEN5173 | Putative electron transfer flavoprotein, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier. (256 aa) |
| | PSEEN5174 | Putative electron transfer flavoprotein, alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier. (410 aa) |
| | PSEEN5175 | Putative iron-sulfur cluster-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (650 aa) |
| | PSEEN5176 | Putative oxidoreductase, FMN-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (686 aa) |
| | PSEEN5177 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (176 aa) |
| | PSEEN5178 | Putative dipeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (325 aa) |
| | PSEEN5186 | Putative transcriptional regulator, AraC family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. (368 aa) |
| | sdaA | L-serine deaminase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (435 aa) |
| | hisF | Imidazole glycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide isomerase; Function of strongly homologous gene; enzyme. (245 aa) |
| | PSEEN5193 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (86 aa) |
| | hisH | Imidazole glycerol phosphate synthetase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Function of strongly homologous gene; enzyme. (197 aa) |
| | PSEEN5196 | Putative permease, MFS superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (552 aa) |
| | thyA | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa) |
| | ptsP | Phosphoenolpyruvate-protein phosphotransferase; Function of strongly homologous gene; enzyme; Belongs to the PEP-utilizing enzyme family. (757 aa) |
| | nudH | (di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (159 aa) |
| | PSEEN5240 | Putative hydrolase, haloacid dehalogenase-like family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (218 aa) |
| | ilvA-2 | Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa) |
| | PSEEN5246 | Putative fumarylacetoacetate (FAA) hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (221 aa) |
| | PSEEN5247 | Putative FAD/FMN-containing dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (465 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (409 aa) |
| | argA | N-alpha-acetylglutamate synthase (amino-acid acetyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (432 aa) |
| | argE | Acetylornithine deacetylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (380 aa) |
| | gcvP-1 | Glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa) |
| | gcvH-1 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | gcvT-1 | Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | argH | Argininosuccinate lyase (Arginosuccinase) (ASAL); Function of strongly homologous gene; enzyme. (464 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa) |
| | ubiC2 | Putative chorismate-pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (185 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (296 aa) |
