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thrB thrB PSEEN0075 PSEEN0075 srpH srpH folA folA glyA-1 glyA-1 cysE cysE purU purU cysM cysM PSEEN1588 PSEEN1588 folC folC metZ metZ folD folD PSEEN2008 PSEEN2008 metY metY PSEEN2446 PSEEN2446 sda-3 sda-3 PSEEN2747 PSEEN2747 ilvA-1 ilvA-1 metH metH PSEEN3862 PSEEN3862 glyA-3 glyA-3 PSEEN3954 PSEEN3954 PSEEN3999 PSEEN3999 cysK cysK PSEEN4039 PSEEN4039 thrC thrC hom hom purT purT gcvH-2 gcvH-2 gcvP-2 gcvP-2 sdaA-2 sdaA-2 gcvT-2 gcvT-2 mdeA mdeA PSEEN4623 PSEEN4623 metE metE PSEEN4641 PSEEN4641 serB serB PSEEN5013 PSEEN5013 metK metK sahH sahH metF metF purU-1 purU-1 soxG soxG soxA soxA soxD soxD soxB soxB glyA-2 glyA-2 ltaE ltaE PSEEN5168 PSEEN5168 PSEEN5169 PSEEN5169 PSEEN5173 PSEEN5173 PSEEN5174 PSEEN5174 PSEEN5175 PSEEN5175 PSEEN5176 PSEEN5176 PSEEN5177 PSEEN5177 PSEEN5178 PSEEN5178 PSEEN5186 PSEEN5186 sdaA sdaA thyA thyA ilvA-2 ilvA-2 gcvP-1 gcvP-1 gcvH-1 gcvH-1 gcvT-1 gcvT-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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thrBHomoserine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pseudomonas-type ThrB family. (316 aa)
PSEEN0075Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (96 aa)
srpHSerine O-acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (310 aa)
folADihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa)
glyA-1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
cysESerine O-acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (261 aa)
purUPutative formyltetrahydrofolate deformylase PurU-2; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa)
cysMCysteine synthase B (O-acetylserine sulfhydrolase B); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the cysteine synthase/cystathionine beta- synthase family. (299 aa)
PSEEN1588Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (160 aa)
folCFolylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. (435 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa)
folDBifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
PSEEN2008Putative L-serine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (305 aa)
metYO-acetylhomoserine sulfhydrylase; Function of strongly homologous gene; enzyme. (425 aa)
PSEEN2446Putative serine O-acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (174 aa)
sda-3L-serine deaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
PSEEN2747Putative 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (342 aa)
ilvA-1Threonine dehydratase biosynthetic (Threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (520 aa)
metHMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1235 aa)
PSEEN3862Threonine synthase; Function of strongly homologous gene; enzyme. (414 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa)
PSEEN3954Aminotransferase; Function of strongly homologous gene; enzyme. (400 aa)
PSEEN3999Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (321 aa)
cysKCysteine synthase A; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (324 aa)
PSEEN4039Putative cystathionine gamma-synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (391 aa)
thrCThreonine synthase; Function of strongly homologous gene; enzyme. (469 aa)
homHomoserine dehydrogenase; Function of strongly homologous gene; enzyme. (450 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
gcvH-2Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
gcvP-2Glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (951 aa)
sdaA-2L-serine deaminase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
gcvT-2Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; Function of strongly homologous gene; enzyme. (373 aa)
mdeAMethionine gamma-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (398 aa)
PSEEN4623Putative oxidoreductase, short-chain dehydrogenase/reductase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (230 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa)
PSEEN4641Putative methylenetetrahydrofolate reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (493 aa)
serBPhosphoserine phosphatase; Function of strongly homologous gene; enzyme. (415 aa)
PSEEN5013Putative threonine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (325 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa)
sahHS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (469 aa)
metF5,10-methylenetetrahydrofolate reductase; Function of strongly homologous gene; enzyme; Belongs to the methylenetetrahydrofolate reductase family. (281 aa)
purU-1Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
soxGSarcosine oxidase, gamma subunit; Function of strongly homologous gene; enzyme. (210 aa)
soxASarcosine oxidase (alpha subunit) oxidoreductase protein; Function of strongly homologous gene; enzyme; Belongs to the GcvT family. (1005 aa)
soxDSarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme. (111 aa)
soxBSarcosine oxidase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (416 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
ltaELow-specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa)
PSEEN5168Putative oxidoreductase, FAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (366 aa)
PSEEN5169Putative iron-sulfur cluster-binding protein, Rieske family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (430 aa)
PSEEN5173Putative electron transfer flavoprotein, beta subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier. (256 aa)
PSEEN5174Putative electron transfer flavoprotein, alpha subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; carrier. (410 aa)
PSEEN5175Putative iron-sulfur cluster-binding protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (650 aa)
PSEEN5176Putative oxidoreductase, FMN-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (686 aa)
PSEEN5177Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (176 aa)
PSEEN5178Putative dipeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (325 aa)
PSEEN5186Putative transcriptional regulator, AraC family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. (368 aa)
sdaAL-serine deaminase I; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the iron-sulfur dependent L-serine dehydratase family. (435 aa)
thyAThymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa)
ilvA-2Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa)
gcvP-1Glycine cleavage complex protein P, glycine decarboxylase, PLP-dependent; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
gcvH-1Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
gcvT-1Glycine cleavage complex protein T, aminomethyltransferase, tetrahydrofolate-dependent; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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