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| | pntB | Pyridine nucleotide transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (478 aa) |
| | pntAB | Pyridine proton-translocating NAD(P) transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (101 aa) |
| | pntAA | Proton-translocating NAD(P) transhydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (373 aa) |
| | PSEEN0244 | Putative hydrolase, haloacid dehalogenase family, subfamily IA, variant 3; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (220 aa) |
| | PSEEN0256 | Putative carbamoyl-phosphate synthase L chain, ATP-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (325 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | rdgB | Non-canonical purine NTP pyrophosphatase RdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa) |
| | PSEEN0420 | Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (169 aa) |
| | birA | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (319 aa) |
| | coaX | Putative transcriptional activator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (249 aa) |
| | PSEEN0473 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (141 aa) |
| | PSEEN0585 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (219 aa) |
| | PSEEN0586 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (150 aa) |
| | nrdR | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (375 aa) |
| | ribC | Riboflavin synthase alpha chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (221 aa) |
| | ribB/A | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (363 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase (Lumazine synthase)(riboflavin synthase beta chain); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (158 aa) |
| | nusB | Transcription termination, L factor (N utilization substance protein B); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (166 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (318 aa) |
| | PSEEN0595 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (247 aa) |
| | ribA | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (205 aa) |
| | PSEEN0597 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (139 aa) |
| | PSEEN0598 | Putative periplasmic cobalamin-binding protein HutB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (270 aa) |
| | ribB | 3,4 dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (216 aa) |
| | add | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (316 aa) |
| | carA | Carbamoyl-phosphate synthase, small chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (378 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1073 aa) |
| | folP | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa) |
| | PSEEN0801 | Putative Xanthine/uracil permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (505 aa) |
| | PSEEN0887 | Putative uracil permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (424 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa) |
| | PSEEN0889 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (185 aa) |
| | PSEEN0890 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (157 aa) |
| | PSEEN0891 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (156 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family. (282 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase (Queuosine biosynthesis protein); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (349 aa) |
| | tgt | Queuine tRNA-ribosyltransferase (tRNA-guanine transglycosylase) (Guanine insertion enzyme); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowi [...] (377 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | argI | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (415 aa) |
| | nrdA | Ribonucleoside diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (958 aa) |
| | PSEEN1364 | Putative GTP pyrophosphokinase RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (746 aa) |
| | PSEEN1365 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (277 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (352 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa) |
| | folE2 | GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (181 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | PSEEN1659 | Putative hydantoin racemase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (242 aa) |
| | PSEEN1660 | Putative transporter, NCS1 nucleoside transporter family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (511 aa) |
| | PSEEN1681 | Putative Xanthine/uracil permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (451 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | nadK | Putative inorganic polyphosphate/ATP-NAD kinase NadK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (296 aa) |
| | pyrD | Dihydroorotate oxydase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (340 aa) |
| | PSEEN1759 | Putative transporter; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (449 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) |
| | ppnP | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (94 aa) |
| | PSEEN1893 | Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (313 aa) |
| | PSEEN1910 | Putative 6-pyruvoyl tetrahydrobiopterin synthase SscR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (118 aa) |
| | PSEEN1936 | Putative 5'-nucleotidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (311 aa) |
| | PSEEN1958 | Putative inosine-uridine preferring nucleoside hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the IUNH family. (336 aa) |
| | PSEEN2055 | Putative decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (457 aa) |
| | pncB-2 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (399 aa) |
| | PSEEN2059 | Putative nicotinamidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (216 aa) |
| | PSEEN2060 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (233 aa) |
| | nudC | Putative NTP pyrophosphohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (276 aa) |
| | purB | Adenylosuccinate lyase; Function of strongly homologous gene; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | cobB-2 | Putative NAD-dependent deacetylase 1 (Regulatory protein SIR2 homolog); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the sirtuin family. Class III subfamily. (249 aa) |
| | PSEEN2516 | Putative Na+-driven multidrug efflux pump MatE; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (475 aa) |
| | PSEEN2517 | Hypothetical protein; No homology to any previously reported sequences. (34 aa) |
| | queE | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (229 aa) |
| | folE | Putative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (202 aa) |
| | PSEEN2520 | Putative 6-pyruvoyl-tetrahydropterin synthase-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (175 aa) |
| | PSEEN2521 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (381 aa) |
| | PSEEN2522 | Hypothetical protein; No homology to any previously reported sequences. (149 aa) |
| | PSEEN2523 | Hypothetical protein; No homology to any previously reported sequences; Belongs to the UbiD family. (412 aa) |
| | PSEEN2524 | Putative hydrolase, MutT/nudix family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (162 aa) |
| | panB-2 | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (269 aa) |
| | ribB/A-2 | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (370 aa) |
| | ccd | Cytosine deaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (141 aa) |
| | PSEEN3119 | Putative dihydroorotase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (449 aa) |
| | PSEEN3251 | Putative dihydroorotate dehydrogenase, FMN-linked, 4Fe-4S ferredoxin-type protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (424 aa) |
| | dht | Dihydropyrimidinase (DHPase) (Hydantoinase) (DHP); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (479 aa) |
| | PSEEN3254 | Putative transporter, NCS1 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (497 aa) |
| | PSEEN3255 | Putative N-carbamoyl-beta-alanine amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (428 aa) |
| | PSEEN3598 | Putative amidohydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (407 aa) |
| | queF | Putative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (276 aa) |
| | sthA | Soluble pyridine nucleotide transhydrogenase (NAD(P)(+) transhydrogenase [B-specific]); Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (464 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. (236 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (352 aa) |
| | queC | Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (224 aa) |
| | queE-2 | Putative radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa) |
| | PSEEN4129 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (160 aa) |
| | pcm | L-isoaspartate protein carboxylmethyltransferase type II; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (225 aa) |
| | surE | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa) |
| | truD | tRNA pseudouridine synthase D, TruD; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (352 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | nadB | L-aspartate oxidase (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1299 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | guaB | Inosine-5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | panE | 2-dehydropantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (305 aa) |
| | coaE | Dephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribF family. (316 aa) |
| | folK-2 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of strongly homologous gene; enzyme. (159 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (266 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (287 aa) |
| | PSEEN4752 | Putative flavin reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (165 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (487 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (535 aa) |
| | purD | Phosphoribosylglycinamide synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. (431 aa) |
| | pncB-1 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (401 aa) |
| | nadE | NAD synthetase, prefers NH3 over glutamine; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | queG | Putative iron-sulfur cluster-binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (354 aa) |
| | rsgA | Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (343 aa) |
| | cpdA | Putative metallo-phosphoesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (267 aa) |
| | pyrR | Putative transcriptional regulator PyrR; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. (172 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Function of strongly homologous gene; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (334 aa) |
| | pyrC-2 | Dihydroorotase, multifunctional complex type; Function of strongly homologous gene; enzyme. (423 aa) |
| | cyaA | Adenylate cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (954 aa) |
| | PSEEN5369 | Putative haloacid dehalogenase-like hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (231 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | dfp | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | spoT | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, mutase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | folE2-2 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (293 aa) |
