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PSEEN0271 PSEEN0271 rluE rluE hrpB hrpB rlmG rlmG rluD rluD rsmI rsmI mraW mraW rlmF rlmF rsuA rsuA rnc rnc era era rimM rimM hrpA hrpA PSEEN3951 PSEEN3951 rluB rluB PSEEN3769 PSEEN3769 rlmM rlmM PSEEN2491 PSEEN2491 rplT rplT rlmL rlmL PSEEN1614 PSEEN1614 rluC rluC rne rne deaD deaD rluA rluA rumA rumA rsmJ rsmJ cafA cafA engA engA rlmN rlmN suhB suhB rsmC rsmC obgE obgE rbfA rbfA rimP rimP ftsJ ftsJ PSEEN0785 PSEEN0785 ksgA ksgA typA typA PSEEN0297 PSEEN0297 sun sun gidB gidB PSEEN5440 PSEEN5440 rph rph PSEEN5081 PSEEN5081 PSEEN5059 PSEEN5059 PSEEN5048 PSEEN5048 rhlE rhlE rlmJ rlmJ rsgA rsgA rlmB rlmB rsfS rsfS rlmH rlmH ybeY ybeY
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PSEEN0271Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (454 aa)
rluEPseudouridylate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pseudouridine synthase RsuA family. (209 aa)
hrpBHelicase, ATP-dependent; Function of strongly homologous gene; enzyme. (842 aa)
rlmGPutative nucleotide methyltransferase; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (374 aa)
rluD23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (320 aa)
rsmIConserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (296 aa)
mraWS-adenosylmethionine methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (315 aa)
rlmFConserved hypothetical protein; Specifically methylates the adenine in position 1618 of 23S rRNA. (316 aa)
rsuA16S rRNA pseudouridylate 516 synthase; Function of strongly homologous gene; enzyme; Belongs to the pseudouridine synthase RsuA family. (249 aa)
rncRibonuclease III, ds RNA; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (229 aa)
eraGTP-binding protein,16S rRNA-binding,ribosome-associated GTPase; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (300 aa)
rimM16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (178 aa)
hrpAATP-dependent helicase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1301 aa)
PSEEN3951Putative ATP-dependent RNA helicase, DEAD box family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the DEAD box helicase family. (454 aa)
rluBRibosomal large subunit pseudouridine synthase B; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the pseudouridine synthase RsuA family. (353 aa)
PSEEN3769Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (114 aa)
rlmMConserved hypothetical protein; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (354 aa)
PSEEN2491Hypothetical protein; No homology to any previously reported sequences. (367 aa)
rplT50S ribosomal protein L20, also posttranslational autoregulator; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
rlmLPutative methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (730 aa)
PSEEN1614Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (175 aa)
rluC23S rRNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (318 aa)
rnePutative ribonuclease E Rne; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1075 aa)
deaDPutative ATP-dependent RNA helicase, DEAD box family; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (562 aa)
rluARibosomal large subunit pseudouridine synthase A; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (211 aa)
rumA23S rRNA m5U1939 methyltransferase RumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (452 aa)
rsmJConserved hypothetical protein; Specifically methylates the guanosine in position 1516 of 16S rRNA. (260 aa)
cafAIbonuclease G; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (485 aa)
engAGTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (488 aa)
rlmNPutative radical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (379 aa)
suhBInositol-1-monophosphatase (IMPase) (Inositol-1-phosphatase) (I-1-Pase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the inositol monophosphatase superfamily. (272 aa)
rsmCPutative ribosomal RNA small subunit methyltransferase C; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (332 aa)
obgERibosomal biogenesis protein ObgE; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (407 aa)
rbfARibosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (132 aa)
rimPConserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (169 aa)
ftsJ23S rRNA U2552 ribose 2'-O-methyltransferase, SAM-dependent; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (208 aa)
PSEEN0785Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (102 aa)
ksgAS-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, kasugamycin resistance; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (266 aa)
typARegulatory protein TypA; Function of homologous gene experimentally demonstrated in an other organism; phenotype. (606 aa)
PSEEN0297Putative methyltransferase; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (204 aa)
sun16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (436 aa)
gidBGlucose-inhibited division protein B; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (216 aa)
PSEEN5440Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (287 aa)
rphRibonuclease PH (RNase PH), tRNA nucleotidyltransferase; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (253 aa)
PSEEN5081Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (235 aa)
PSEEN5059Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (141 aa)
PSEEN5048Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (239 aa)
rhlEATP-dependent RNA helicase RhlE, DEAD box family; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (634 aa)
rlmJConserved hypothetical protein; Specifically methylates the adenine in position 2030 of 23S rRNA. (278 aa)
rsgAConserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (343 aa)
rlmBRNA methyltransferase, TrmH family, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA. (247 aa)
rsfSConserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (142 aa)
rlmHConserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (155 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (157 aa)
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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