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prpB prpB PSEEN3954 PSEEN3954 phhC phhC aruF aruF aruG aruG aruD aruD aruB aruB PSEEN3874 PSEEN3874 lysA-1 lysA-1 lysR lysR PSEEN3214 PSEEN3214 aroF-2 aroF-2 aspC aspC tyrB-2 tyrB-2 kdgD kdgD garD garD PSEEN2641 PSEEN2641 hutH-2 hutH-2 psmB psmB PSEEN2474 PSEEN2474 ilvE ilvE aroQ-2 aroQ-2 aroE-2 aroE-2 aro aro gdhB gdhB folC folC asd asd tyrB tyrB PSEEN1622 PSEEN1622 aroC aroC aroA aroA pheA pheA fumC fumC lpxL lpxL ppc ppc PSEEN1180 PSEEN1180 aroE aroE PSEEN0172 PSEEN0172 PSEEN0265 PSEEN0265 folA folA PSEEN0327 PSEEN0327 aroK aroK aroB aroB gltB gltB PSEEN0356 PSEEN0356 PSEEN0389 PSEEN0389 folB folB PSEEN0420 PSEEN0420 gudD gudD dapB dapB folP folP gdhA gdhA nadC nadC PSEEN0973 PSEEN0973 fumC-1 fumC-1 aspA aspA dapF dapF lysA-2 lysA-2 hutC hutC hutU hutU hutH hutH hutI hutI PSEEN5074 PSEEN5074 putA putA putP putP aroQ-1 aroQ-1 folK-2 folK-2 PSEEN4356 PSEEN4356 PSEEN4299 PSEEN4299 nadB nadB hom hom dapE dapE dapD dapD PSEEN4223 PSEEN4223 nadA nadA dapA dapA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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prpBMethylisocitrate lyase PrpB; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (296 aa)
PSEEN3954Aminotransferase; Function of strongly homologous gene; enzyme. (400 aa)
phhCAromatic-amino-acid aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (397 aa)
aruFArginine succinyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (339 aa)
aruGArginine succinyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (342 aa)
aruDSuccinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (487 aa)
aruBSuccinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (449 aa)
PSEEN3874Aspartate kinase, monofunctional class; Function of strongly homologous gene; enzyme; Belongs to the aspartokinase family. (411 aa)
lysA-1Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (409 aa)
lysRTranscriptional activator for lysine biosynthesis (LysR family); Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the LysR transcriptional regulatory family. (304 aa)
PSEEN3214Putative shikimate 5-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (273 aa)
aroF-23-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa)
aspCAspartate aminotransferase; Function of strongly homologous gene; enzyme. (409 aa)
tyrB-2Aromatic amino acid aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (398 aa)
kdgD5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy-glucarate dehydratase); Function of strongly homologous gene; enzyme; Belongs to the DapA family. (305 aa)
garDD-galactarate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (517 aa)
PSEEN2641Putative 3-dehydroquinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (624 aa)
hutH-2Histidine ammonia-lyase; Function of strongly homologous gene; enzyme. (507 aa)
psmBIsochorismate pyruvate-lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (105 aa)
PSEEN2474Putative 3-dehydroquinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (392 aa)
ilvEBranched-chain amino acid aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (339 aa)
aroQ-23-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
aroE-2Putative shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (282 aa)
aroPhospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
gdhBNAD-specific glutamate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1621 aa)
folCFolylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. (435 aa)
asdAspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa)
tyrBAromatic-amino-acid aminotransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (398 aa)
PSEEN1622Putative 4-amino-4-deoxychorismate lyase PabC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (271 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
aroAPutative prephenate dehydrogenase, putative/3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (746 aa)
pheABifunctional chorismate mutase/prephenate dehydratase PheA; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (364 aa)
fumCFumarase C (fumarate hydratase Class II); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
lpxLPutative lipid A biosynthesis lauroyl acyltransferase HtrB; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (311 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (875 aa)
PSEEN1180Putative ferredoxin-dependent glutamate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the glutamate synthase family. (539 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (281 aa)
PSEEN0172Putative dipeptidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (576 aa)
PSEEN0265Putative glutamate synthase, large subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the glutamate synthase family. (556 aa)
folADihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa)
PSEEN0327Putative bifunctional protein (MaeB) [Includes: putative malic oxidoreductase (N-terminal); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (422 aa)
aroKShikimate-kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (365 aa)
gltBGlutamate synthase [NADPH] large chain precursor (GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1481 aa)
PSEEN0356Putative phenylalanine/histidine ammonia-lyase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (514 aa)
PSEEN0389Putative chorismate mutase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (179 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa)
PSEEN0420Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (169 aa)
gudDD-glucarate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (451 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (267 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa)
gdhAGlutamate dehydrogenase, NADP-specific; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa)
nadCNicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family. (282 aa)
PSEEN0973Putative Dihydrodipicolinate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the DapA family. (303 aa)
fumC-1Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
aspAAspartate ammonia-lyase (aspartase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (478 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa)
lysA-2Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa)
hutCHistidine utilization repressor; Function of homologous gene experimentally demonstrated in an other organism; regulator. (248 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (557 aa)
hutHHistidine ammonia-lyase; Function of strongly homologous gene; enzyme. (510 aa)
hutIImidazolonepropionase; Function of strongly homologous gene; enzyme; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (401 aa)
PSEEN5074Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (207 aa)
putAProline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1317 aa)
putPMajor sodium:proline symporter (SSS family); Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (492 aa)
aroQ-13-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
folK-22-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of strongly homologous gene; enzyme. (159 aa)
PSEEN4356Putative carboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family. (289 aa)
PSEEN4299Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (84 aa)
nadBL-aspartate oxidase (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa)
homHomoserine dehydrogenase; Function of strongly homologous gene; enzyme. (450 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (383 aa)
dapDPutative 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (344 aa)
PSEEN4223Putative aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (397 aa)
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (352 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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