9 items (Pseudomonas entomophila) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	folP	Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa)
	folE	Putative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (202 aa)
	folB	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa)
	folA	Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa)
	PSEEN2180	Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (204 aa)
	folC	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. (435 aa)
	folE2	GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (181 aa)
	PSEEN0420	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (169 aa)
	folK-2	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of strongly homologous gene; enzyme. (159 aa)

Your Current Organism:

Pseudomonas entomophila

NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSEEN0420	folB	PSEEN0420	PSEEN0419	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	0.996
PSEEN0420	folC	PSEEN0420	PSEEN1692	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	0.504
PSEEN0420	folE	PSEEN0420	PSEEN2519	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Putative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.772
PSEEN0420	folE2	PSEEN0420	PSEEN1521	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.773
PSEEN0420	folK-2	PSEEN0420	PSEEN4734	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of strongly homologous gene; enzyme.	0.920
PSEEN0420	folP	PSEEN0420	PSEEN0788	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.989
PSEEN2180	folC	PSEEN2180	PSEEN1692	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	0.568
folA	folB	PSEEN0273	PSEEN0419	Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	0.401
folA	folC	PSEEN0273	PSEEN1692	Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	0.933
folA	folP	PSEEN0273	PSEEN0788	Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.401
folB	PSEEN0420	PSEEN0419	PSEEN0420	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.996
folB	folA	PSEEN0419	PSEEN0273	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.401
folB	folC	PSEEN0419	PSEEN1692	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	0.663
folB	folE	PSEEN0419	PSEEN2519	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Putative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.837
folB	folE2	PSEEN0419	PSEEN1521	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.836
folB	folK-2	PSEEN0419	PSEEN4734	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of strongly homologous gene; enzyme.	0.988
folB	folP	PSEEN0419	PSEEN0788	Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.	Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.	0.993
folC	PSEEN0420	PSEEN1692	PSEEN0420	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme.	0.504
folC	PSEEN2180	PSEEN1692	PSEEN2180	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	Conserved hypothetical protein; Homologs of previously reported genes of unknown function.	0.568
folC	folA	PSEEN1692	PSEEN0273	Folylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family.	Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	0.933