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| | PSEEN2754 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (226 aa) |
| | hdtS | N-acylhomoserine lactone synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (256 aa) |
| | PSEEN0019 | Putative lipid A biosynthesis lauroyl acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (295 aa) |
| | PSEEN0082 | Putative DNAse I-like hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (284 aa) |
| | gcdH | glutaryl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (393 aa) |
| | PSEEN0232 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (266 aa) |
| | fdhD | Putative formate dehydrogenase accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (275 aa) |
| | rffA | TDP-4-oxo-6-deoxy-D-glucose transaminase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the DegT/DnrJ/EryC1 family. (381 aa) |
| | PSEEN0256 | Putative carbamoyl-phosphate synthase L chain, ATP-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (325 aa) |
| | PSEEN0259 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (252 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa) |
| | PSEEN0306 | Putative thiamine biosynthesis protein ThiS; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (71 aa) |
| | thiG | Putative thiamine biosynthesis protein ThiG, thiazole moiety; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (270 aa) |
| | PSEEN0363 | Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (272 aa) |
| | thiI | Thiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (484 aa) |
| | plsY | Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (189 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase); Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (336 aa) |
| | coaX | Putative transcriptional activator; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (249 aa) |
| | thiL | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (318 aa) |
| | pgpA | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (167 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa) |
| | PSEEN0706 | Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (207 aa) |
| | PSEEN0710 | Putative CDP-alcohol phosphatidyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (201 aa) |
| | PSEEN0734 | Putative ribosomal protein S6 modification protein-related protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (528 aa) |
| | carA | Carbamoyl-phosphate synthase, small chain; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (378 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1073 aa) |
| | prs | Ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (309 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (286 aa) |
| | moeB | Molybdopterin biosynthesis MoeB protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (251 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (212 aa) |
| | PSEEN0889 | Putative hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (185 aa) |
| | pta | Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (696 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NadC/ModD family. (282 aa) |
| | PSEEN0979 | Hypothetical protein; No homology to any previously reported sequences. (331 aa) |
| | suhB | Inositol-1-monophosphatase (IMPase) (Inositol-1-phosphatase) (I-1-Pase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the inositol monophosphatase superfamily. (272 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | ispG | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (369 aa) |
| | PSEEN1136 | Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (260 aa) |
| | PSEEN1142 | Putative phospholipase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (385 aa) |
| | purU | Putative formyltetrahydrofolate deformylase PurU-2; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (283 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (348 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | pdxH | Putative pyridoxamine 5'-phosphate oxidase PdxH; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (215 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (415 aa) |
| | nrdA | Ribonucleoside diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (958 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (217 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (352 aa) |
| | PSEEN1408 | Putative acyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (624 aa) |
| | lpxL | Putative lipid A biosynthesis lauroyl acyltransferase HtrB; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (311 aa) |
| | cmk | Cytidylate kinase (cytidine monophosphate (CMP) kinase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (228 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (233 aa) |
| | folE2 | GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (181 aa) |
| | PSEEN1546 | Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase PlsC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (238 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase (Lipid A 4'-kinase); Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (336 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (336 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | PSEEN1630 | Putative molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (322 aa) |
| | accD | acetylCoA carboxylase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (297 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa) |
| | nadK | Putative inorganic polyphosphate/ATP-NAD kinase NadK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (296 aa) |
| | pyrD | Dihydroorotate oxydase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (340 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa) |
| | folD | Bifunctional protein [Includes: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa) |
| | PSEEN1919 | Putative acetyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (629 aa) |
| | pncB-2 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (399 aa) |
| | lpxH | UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (240 aa) |
| | PSEEN2181 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (199 aa) |
| | purB | Adenylosuccinate lyase; Function of strongly homologous gene; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa) |
| | PSEEN2314 | Hypothetical protein; No homology to any previously reported sequences. (174 aa) |
| | PSEEN2473 | Putative PLP-dependent transaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the DegT/DnrJ/EryC1 family. (424 aa) |
| | folE | Putative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (202 aa) |
| | PSEEN2522 | Hypothetical protein; No homology to any previously reported sequences. (149 aa) |
| | mhbD | Gentisate 1,2-dioxygenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (351 aa) |
| | PSEEN2729 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (202 aa) |
| | PSEEN2871 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (187 aa) |
| | PSEEN2938 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (183 aa) |
| | PSEEN2957 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (155 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (191 aa) |
| | clsB | Putative phospholipase (biosynthetic); Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (400 aa) |
| | PSEEN3109 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (272 aa) |
| | PSEEN3119 | Putative dihydroorotase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (449 aa) |
| | PSEEN3159 | Putative acetoacetyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (650 aa) |
| | dht | Dihydropyrimidinase (DHPase) (Hydantoinase) (DHP); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (479 aa) |
| | PSEEN3259 | Putative kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (185 aa) |
| | PSEEN3303 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (171 aa) |
| | PSEEN3320 | Hypothetical protein; No homology to any previously reported sequences. (402 aa) |
| | PSEEN3361 | Putative Glycosyl transferase, group 2 family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (243 aa) |
| | PSEEN3362 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (90 aa) |
| | PSEEN3363 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (492 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (186 aa) |
| | fadDx | acetyl-coA synthetase/AMP-(fatty) acid ligase FadDx; Function of strongly homologous gene; enzyme. (548 aa) |
| | PSEEN3588 | Putative oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (348 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase, biosynthetic; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (341 aa) |
| | sucD | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (294 aa) |
| | PSEEN3741 | Conserved hypothetical protein; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily. (295 aa) |
| | moeA | Molybdopterin biosynthesis protein, molybdenum incorporation step; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (401 aa) |
| | moaB-1 | Molybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (179 aa) |
| | fliI | Flagellum-specific ATP synthase; Function of strongly homologous gene; enzyme. (451 aa) |
| | phnN | ATP-binding protein PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (207 aa) |
| | acs-1 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa) |
| | PSEEN3916 | Putative metallo-dependent phosphoesterase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (271 aa) |
| | moaA | Putative molybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (334 aa) |
| | moaB-2 | Molybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (179 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. (236 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (352 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (121 aa) |
| | PSEEN4129 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the CinA family. (160 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (235 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase (alpha subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (315 aa) |
| | lpxB | Lipid A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (375 aa) |
| | lpxA | UDP-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | lpxD | UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (351 aa) |
| | dxr | 1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (404 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Function of strongly homologous gene; enzyme; Belongs to the CDS family. (271 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa) |
| | plsB | Glycerol-3-phosphate acyltransferase; Function of strongly homologous gene; enzyme; Belongs to the GPAT/DAPAT family. (828 aa) |
| | purT | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa) |
| | nadB | L-aspartate oxidase (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate. (534 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1299 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (525 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (303 aa) |
| | gmhA | Phosphoheptose isomerase with phosphosugar-binding domain; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (197 aa) |
| | moaE | Molybdenum cofactor biosynthesis protein E; Function of homologous gene experimentally demonstrated in an other organism; factor. (148 aa) |
| | moaD | Molybdenum cofactor biosynthesis protein D; Function of strongly homologous gene; factor. (81 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa) |
| | PSEEN4664 | Hypothetical protein; No homology to any previously reported sequences. (192 aa) |
| | coaE | Dephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (207 aa) |
| | PSEEN4683 | Putative oxidoreductase, FAD-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (365 aa) |
| | ispH | Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (315 aa) |
| | ribF | Riboflavin biosynthesis protein RibF; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribF family. (316 aa) |
| | PSEEN4708 | Putative phosphatidylserine synthase PssA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (280 aa) |
| | acs-2 | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (644 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (487 aa) |
| | thiD | Phosphomethylpyrimidine kinase ThiD; Function of strongly homologous gene; enzyme. (265 aa) |
| | thiE | Thiamin-phosphate pyrophosphorylase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (207 aa) |
| | corC | Magnesium and cobalt efflux protein CorC; Function of homologous gene experimentally demonstrated in an other organism; transporter. (279 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (219 aa) |
| | PSEEN4849 | Putative transferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (203 aa) |
| | PSEEN4850 | Putative IPP isomerase type 1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (177 aa) |
| | accC-1 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (535 aa) |
| | purD | Phosphoribosylglycinamide synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. (431 aa) |
| | pncB-1 | Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (401 aa) |
| | nadE | NAD synthetase, prefers NH3 over glutamine; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (275 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (287 aa) |
| | thiC | Hydroxymethylpyrimidine moiety synthesis in thiamin biosynthesis; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (626 aa) |
| | waaA | 3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (422 aa) |
| | epd | Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. (353 aa) |
| | PSEEN5058 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. (189 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic subunit; Function of strongly homologous gene; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (334 aa) |
| | pyrC-2 | Dihydroorotase, multifunctional complex type; Function of strongly homologous gene; enzyme. (423 aa) |
| | aceF | Dihydrolipoamide S-acetyltransferase, E2 component of the pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (543 aa) |
| | purU-1 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa) |
| | thyA | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (323 aa) |
| | cyaA | Adenylate cyclase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (954 aa) |
| | PSEEN5370 | Putative glycosyl transferase, family 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (336 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | PSEEN5422 | Putative phospholipase D/Transphosphatidylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (518 aa) |
| | dfp | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (206 aa) |
| | spoT | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (702 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, mutase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa) |
| | accC-2 | Biotin carboxylase (A subunit of acetyl-CoA carboxylase); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (471 aa) |
| | pdxY | Pyridoxal kinase 2/pyridoxine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (290 aa) |
| | folE2-2 | Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (293 aa) |
| | cls | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (479 aa) |
| | hcnC | Hydrogen cyanide synthase HcnC; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (416 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (455 aa) |
| | atpC | ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (139 aa) |
| | atpD | ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (458 aa) |
| | atpG | ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (286 aa) |
| | atpA | ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (514 aa) |
| | atpH | ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa) |
| | atpF | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (156 aa) |
| | atpE | ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (85 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (289 aa) |
