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rplB rplB ribA ribA smpB smpB hmp hmp iscU iscU capB capB folE2 folE2 capA capA nhaB nhaB cspD cspD folE folE PSEEN4100 PSEEN4100 tsf tsf rpsB rpsB glnD glnD PSEEN4235 PSEEN4235 tapB tapB cysNC cysNC cysP cysP phoB phoB hcnC hcnC rpoB rpoB dnaG dnaG gltB gltB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplB50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (274 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (205 aa)
smpBssrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...] (160 aa)
hmpFlavohemoprotein; Function of strongly homologous gene; enzyme; Belongs to the globin family. (392 aa)
iscUIron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa)
capBCold shock protein CapB; Function of homologous gene experimentally demonstrated in an other organism; regulator. (69 aa)
folE2GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (181 aa)
capACold shock protein CapA; Function of homologous gene experimentally demonstrated in an other organism; regulator. (70 aa)
nhaBSodium:proton antiporter NhaB; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family. (500 aa)
cspDCold-shock protein CspD; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. (87 aa)
folEPutative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (202 aa)
PSEEN4100Putative cold shock protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. (196 aa)
tsfProtein chain elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (287 aa)
rpsB30S ribosomal protein S2; Function of homologous gene experimentally demonstrated in an other organism; structural protein; Belongs to the universal ribosomal protein uS2 family. (245 aa)
glnDBifunctional uridylyltransferase/uridylyl-removing enzyme; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and met [...] (900 aa)
PSEEN4235Putative cold shock protein CspE-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. (69 aa)
tapBCold shock protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. (69 aa)
cysNCSulfate adenylyltransferase, subunit 1/adenylylsulfate kinase; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (633 aa)
cysPSulfate/thiosulfate import ABC transporter, periplasmic sulfate-binding protein; Function of homologous gene experimentally demonstrated in an other organism; transporter. (335 aa)
phoBPhosphate regulon transcriptional regulatory protein PhoB; Function of homologous gene experimentally demonstrated in an other organism; regulator. (229 aa)
hcnCHydrogen cyanide synthase HcnC; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (416 aa)
rpoBRNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1357 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (660 aa)
gltBGlutamate synthase [NADPH] large chain precursor (GOGAT); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1481 aa)
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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