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folA folA folB folB PSEEN0420 PSEEN0420 ribB/A ribB/A ribA ribA folP folP folE2 folE2 PSEEN1622 PSEEN1622 PSEEN1630 PSEEN1630 folC folC PSEEN1897 PSEEN1897 PSEEN1910 PSEEN1910 queE queE folE folE PSEEN2520 PSEEN2520 PSEEN2871 PSEEN2871 mobA mobA ribB/A-2 ribB/A-2 queF queF moeA moeA moaB-1 moaB-1 phhA phhA phhB phhB moaA moaA moaB-2 moaB-2 queC queC queE-2 queE-2 moaE moaE moaC moaC PSEEN4623 PSEEN4623 folK-2 folK-2 folE2-2 folE2-2
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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folADihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa)
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (118 aa)
PSEEN0420Putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (169 aa)
ribB/A3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (363 aa)
ribAGTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. (205 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa)
folE2GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (181 aa)
PSEEN1622Putative 4-amino-4-deoxychorismate lyase PabC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (271 aa)
PSEEN1630Putative molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (322 aa)
folCFolylpolyglutamate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the folylpolyglutamate synthase family. (435 aa)
PSEEN1897Putative para-aminodeoxychorismate synthase subunit I PabB; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (447 aa)
PSEEN1910Putative 6-pyruvoyl tetrahydrobiopterin synthase SscR; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (118 aa)
queEConserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (229 aa)
folEPutative GTP cyclohydrolase I; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (202 aa)
PSEEN2520Putative 6-pyruvoyl-tetrahydropterin synthase-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (175 aa)
PSEEN2871Conserved hypothetical protein; Homologs of previously reported genes of unknown function. (187 aa)
mobAMolybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family. (191 aa)
ribB/A-23,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. (370 aa)
queFPutative GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (276 aa)
moeAMolybdopterin biosynthesis protein, molybdenum incorporation step; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (401 aa)
moaB-1Molybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (179 aa)
phhAPhenylalanine-4-hydroxylase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (262 aa)
phhBPterin-4-alpha-carbinolamine dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (118 aa)
moaAPutative molybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (334 aa)
moaB-2Molybdopterin biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (179 aa)
queCConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (224 aa)
queE-2Putative radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (215 aa)
moaEMolybdenum cofactor biosynthesis protein E; Function of homologous gene experimentally demonstrated in an other organism; factor. (148 aa)
moaCMolybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa)
PSEEN4623Putative oxidoreductase, short-chain dehydrogenase/reductase family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (230 aa)
folK-22-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase; Function of strongly homologous gene; enzyme. (159 aa)
folE2-2Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (293 aa)
Your Current Organism:
Pseudomonas entomophila
NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48
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