(16 nodes) Terpenoid backbone biosynthesis network (Pseudomonas entomophila)

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	dxs	1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa)
	ispA	Geranyltranstransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. (295 aa)
	PSEEN0664	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
	ispB	Octaprenyl-diphosphate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family. (322 aa)
	ispE	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (286 aa)
	ispG	1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (369 aa)
	PSEEN2543	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
	pcaF-2	Beta-ketoadipyl CoA thiolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	PSEEN3197	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	fadAx	acetyl-CoA acetyltransferase with thiolase domain FadAx; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
	ispF	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa)
	ispD	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (235 aa)
	dxr	1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (404 aa)
	uppS	Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (251 aa)
	phbA	acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
	ispH	Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (315 aa)

Your Current Organism:

Pseudomonas entomophila

NCBI taxonomy Id: 384676
Other names: P. entomophila L48, Pseudomonas entomophila L48, Pseudomonas entomophila str. L48, Pseudomonas entomophila strain L48

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PSEEN0664	PSEEN2543	PSEEN0664	PSEEN2543	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
PSEEN0664	PSEEN3197	PSEEN0664	PSEEN3197	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.686
PSEEN0664	fadAx	PSEEN0664	PSEEN3547	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase with thiolase domain FadAx; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.689
PSEEN0664	pcaF-2	PSEEN0664	PSEEN2795	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Beta-ketoadipyl CoA thiolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.682
PSEEN0664	phbA	PSEEN0664	PSEEN4635	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.684
PSEEN2543	PSEEN0664	PSEEN2543	PSEEN0664	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
PSEEN2543	PSEEN3197	PSEEN2543	PSEEN3197	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
PSEEN2543	fadAx	PSEEN2543	PSEEN3547	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase with thiolase domain FadAx; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
PSEEN2543	pcaF-2	PSEEN2543	PSEEN2795	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Beta-ketoadipyl CoA thiolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.648
PSEEN2543	phbA	PSEEN2543	PSEEN4635	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
PSEEN3197	PSEEN0664	PSEEN3197	PSEEN0664	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetyl-CoA acetyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.686
PSEEN3197	PSEEN2543	PSEEN3197	PSEEN2543	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Putative 3-ketoacyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.600
PSEEN3197	fadAx	PSEEN3197	PSEEN3547	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase with thiolase domain FadAx; Function of strongly homologous gene; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.663
PSEEN3197	pcaF-2	PSEEN3197	PSEEN2795	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	Beta-ketoadipyl CoA thiolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.630
PSEEN3197	phbA	PSEEN3197	PSEEN4635	Putative Acetoacetyl-CoA thiolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family.	0.622
dxr	dxs	PSEEN4214	PSEEN0600	1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.	0.986
dxr	ispA	PSEEN4214	PSEEN0601	1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	Geranyltranstransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the FPP/GGPP synthase family.	0.517
dxr	ispD	PSEEN4214	PSEEN4198	1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).	0.987
dxr	ispE	PSEEN4214	PSEEN0858	1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.	0.854
dxr	ispF	PSEEN4214	PSEEN4194	1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.	2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).	0.870