(40 nodes) (2016) Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy. network (Glycine max)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	A0A0R0EVX5	Ncstrn_small domain-containing protein. (663 aa)
	I1K835_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (358 aa)
	I1JZI3_SOYBN	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (456 aa)
	I1JZ49_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (488 aa)
	I1JTP1_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (327 aa)
	I1JTP0_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (375 aa)
	I1JTN9_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (349 aa)
	I1JK51_SOYBN	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (385 aa)
	I1JFT5_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	I1JCK5_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (485 aa)
	C6TJ91_SOYBN	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (112 aa)
	C6TG33_SOYBN	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (420 aa)
	C6SZC5_SOYBN	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (112 aa)
	C6SYA8_SOYBN	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (113 aa)
	C6SX87_SOYBN	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (113 aa)
	A0A0R0IQ59	Uncharacterized protein; Belongs to the cyclin family. (471 aa)
	A0A0R0FR66	Uncharacterized protein; Belongs to the cyclin family. (459 aa)
	CYCA1;1	Mitotic cyclin a2-type; Belongs to the cyclin family. (484 aa)
	PI3K2_SOYBN	Phosphatidylinositol 3-kinase, nodule isoform; Associated with membrane proliferation. (812 aa)
	PI3K1_SOYBN	Phosphatidylinositol 3-kinase, root isoform; Associated with membrane proliferation. (814 aa)
	K7M6F5_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (461 aa)
	K7KZF4_SOYBN	Uncharacterized protein; Belongs to the cyclin family. (476 aa)
	K7KUJ6_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (480 aa)
	K7KTL8_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (469 aa)
	CYCA2;1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (488 aa)
	I1N8G3_SOYBN	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (417 aa)
	I1MXJ6_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (367 aa)
	I1MT67_SOYBN	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (457 aa)
	I1MN90_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (530 aa)
	I1MDB2_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	I1MA73_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (504 aa)
	I1MA57_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (496 aa)
	I1M8R8_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (364 aa)
	I1M506_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	I1LXG2_SOYBN	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (503 aa)
	I1LQJ4_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	I1LMA4_SOYBN	Ncstrn_small domain-containing protein. (669 aa)
	I1LJV8_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
	I1KNX5_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (541 aa)
	I1KAB0_SOYBN	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (491 aa)

Your Current Organism:

Glycine max

NCBI taxonomy Id: 3847
Other names: G. max, Glycine max (L.) Merr., soybean, soybeans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A0R0EVX5	I1JK51_SOYBN	A0A0R0EVX5	I1JK51	Ncstrn_small domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
A0A0R0EVX5	I1JZI3_SOYBN	A0A0R0EVX5	I1JZI3	Ncstrn_small domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
A0A0R0EVX5	I1MT67_SOYBN	A0A0R0EVX5	I1MT67	Ncstrn_small domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
A0A0R0EVX5	I1N8G3_SOYBN	A0A0R0EVX5	I1N8G3	Ncstrn_small domain-containing protein.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.998
A0A0R0FR66	C6SX87_SOYBN	A0A0R0FR66	C6SX87	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0FR66	C6SYA8_SOYBN	A0A0R0FR66	C6SYA8	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0FR66	C6SZC5_SOYBN	A0A0R0FR66	C6SZC5	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0FR66	C6TJ91_SOYBN	A0A0R0FR66	C6TJ91	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0IQ59	C6SX87_SOYBN	A0A0R0IQ59	C6SX87	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0IQ59	C6SYA8_SOYBN	A0A0R0IQ59	C6SYA8	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0IQ59	C6SZC5_SOYBN	A0A0R0IQ59	C6SZC5	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
A0A0R0IQ59	C6TJ91_SOYBN	A0A0R0IQ59	C6TJ91	Uncharacterized protein; Belongs to the cyclin family.	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.796
C6SX87_SOYBN	A0A0R0FR66	C6SX87	A0A0R0FR66	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Uncharacterized protein; Belongs to the cyclin family.	0.796
C6SX87_SOYBN	A0A0R0IQ59	C6SX87	A0A0R0IQ59	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Uncharacterized protein; Belongs to the cyclin family.	0.796
C6SX87_SOYBN	C6TG33_SOYBN	C6SX87	C6TG33	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.565
C6SX87_SOYBN	CYCA1;1	C6SX87	Q39879	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Mitotic cyclin a2-type; Belongs to the cyclin family.	0.798
C6SX87_SOYBN	CYCA2;1	C6SX87	K7KIM9	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.796
C6SX87_SOYBN	I1JCK5_SOYBN	C6SX87	I1JCK5	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.473
C6SX87_SOYBN	I1JFT5_SOYBN	C6SX87	I1JFT5	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.473
C6SX87_SOYBN	I1JK51_SOYBN	C6SX87	I1JK51	Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.774