(17 nodes) Valine, leucine and isoleucine biosynthesis network (Botryotinia calthae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	A0A4Y8CHU2	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa)
	A0A4Y8CJY3	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (335 aa)
	A0A4Y8CM85	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (775 aa)
	A0A4Y8CS12	ACT domain-containing protein. (323 aa)
	A0A4Y8CYD6	Uncharacterized protein. (601 aa)
	A0A4Y8CYH0	Uncharacterized protein. (379 aa)
	A0A4Y8CYK2	Uncharacterized protein. (609 aa)
	A0A4Y8CZU6	Uncharacterized protein. (179 aa)
	A0A4Y8D0L5	Uncharacterized protein. (354 aa)
	A0A4Y8D2N3	Threonine dehydratase. (567 aa)
	A0A4Y8D332	Uncharacterized protein; Belongs to the TPP enzyme family. (584 aa)
	A0A4Y8D6J0	Uncharacterized protein; Belongs to the TPP enzyme family. (606 aa)
	A0A4Y8D7M4	Pyruvate carboxyltransferase domain-containing protein. (639 aa)
	A0A4Y8D8I3	PALP domain-containing protein. (245 aa)
	A0A4Y8DER3	Acetolactate synthase. (699 aa)
	A0A4Y8DG26	Uncharacterized protein. (405 aa)
	A0A4Y8DHM1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (425 aa)

Your Current Organism:

Botryotinia calthae

NCBI taxonomy Id: 38488
Other names: B. calthae, Botrytis calthae, Botrytis calthae Hennebert

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A4Y8CHU2	A0A4Y8CJY3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.422
A0A4Y8CHU2	A0A4Y8CM85	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.939
A0A4Y8CHU2	A0A4Y8CS12	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	ACT domain-containing protein.	0.947
A0A4Y8CHU2	A0A4Y8CYD6	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein.	0.581
A0A4Y8CHU2	A0A4Y8CYK2	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein.	0.566
A0A4Y8CHU2	A0A4Y8D0L5	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein.	0.454
A0A4Y8CHU2	A0A4Y8D2N3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Threonine dehydratase.	0.905
A0A4Y8CHU2	A0A4Y8D332	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein; Belongs to the TPP enzyme family.	0.454
A0A4Y8CHU2	A0A4Y8D6J0	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein; Belongs to the TPP enzyme family.	0.454
A0A4Y8CHU2	A0A4Y8D7M4	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Pyruvate carboxyltransferase domain-containing protein.	0.671
A0A4Y8CHU2	A0A4Y8D8I3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	PALP domain-containing protein.	0.904
A0A4Y8CHU2	A0A4Y8DER3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Acetolactate synthase.	0.950
A0A4Y8CJY3	A0A4Y8CHU2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.422
A0A4Y8CJY3	A0A4Y8CM85	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.531
A0A4Y8CJY3	A0A4Y8CS12	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	ACT domain-containing protein.	0.788
A0A4Y8CJY3	A0A4Y8CYD6	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.971
A0A4Y8CJY3	A0A4Y8CYH0	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.920
A0A4Y8CJY3	A0A4Y8CYK2	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.971
A0A4Y8CJY3	A0A4Y8D0L5	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.659
A0A4Y8CJY3	A0A4Y8D2N3	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	Threonine dehydratase.	0.875