(28 nodes) Valine, leucine and isoleucine biosynthesis network (Botryotinia calthae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A4Y8D1S6	Uncharacterized protein. (198 aa)
	A0A4Y8CDD4	Zn(2)-C6 fungal-type domain-containing protein. (282 aa)
	A0A4Y8CHU2	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa)
	A0A4Y8CJY3	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (335 aa)
	A0A4Y8CM85	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (775 aa)
	A0A4Y8CNP7	WW domain-containing protein. (704 aa)
	A0A4Y8CS12	ACT domain-containing protein. (323 aa)
	A0A4Y8CTL8	HET domain-containing protein. (419 aa)
	A0A4Y8CX14	HET domain-containing protein. (624 aa)
	A0A4Y8CYD6	Uncharacterized protein. (601 aa)
	A0A4Y8CYH0	Uncharacterized protein. (379 aa)
	A0A4Y8CYK2	Uncharacterized protein. (609 aa)
	A0A4Y8CZU6	Uncharacterized protein. (179 aa)
	A0A4Y8D2N3	Threonine dehydratase. (567 aa)
	A0A4Y8D330	HET domain-containing protein. (675 aa)
	A0A4Y8D3S0	Uncharacterized protein. (382 aa)
	A0A4Y8D5J8	HET domain-containing protein. (229 aa)
	A0A4Y8D5P7	Uncharacterized protein. (514 aa)
	A0A4Y8D7M0	Uncharacterized protein. (367 aa)
	A0A4Y8D7M4	Pyruvate carboxyltransferase domain-containing protein. (639 aa)
	A0A4Y8D8I3	PALP domain-containing protein. (245 aa)
	A0A4Y8D9J7	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (398 aa)
	A0A4Y8DCT2	Uncharacterized protein. (217 aa)
	A0A4Y8DER3	Acetolactate synthase. (699 aa)
	A0A4Y8DFN4	Uncharacterized protein. (481 aa)
	A0A4Y8DG26	Uncharacterized protein. (405 aa)
	A0A4Y8DGC3	Uncharacterized protein. (178 aa)
	A0A4Y8DHM1	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (425 aa)

Your Current Organism:

Botryotinia calthae

NCBI taxonomy Id: 38488
Other names: B. calthae, Botrytis calthae, Botrytis calthae Hennebert

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A4Y8CDD4	A0A4Y8CJY3	Zn(2)-C6 fungal-type domain-containing protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.422
A0A4Y8CDD4	A0A4Y8CM85	Zn(2)-C6 fungal-type domain-containing protein.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.863
A0A4Y8CDD4	A0A4Y8CS12	Zn(2)-C6 fungal-type domain-containing protein.	ACT domain-containing protein.	0.785
A0A4Y8CDD4	A0A4Y8CYD6	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.433
A0A4Y8CDD4	A0A4Y8CYK2	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.433
A0A4Y8CDD4	A0A4Y8D2N3	Zn(2)-C6 fungal-type domain-containing protein.	Threonine dehydratase.	0.615
A0A4Y8CDD4	A0A4Y8D7M4	Zn(2)-C6 fungal-type domain-containing protein.	Pyruvate carboxyltransferase domain-containing protein.	0.671
A0A4Y8CDD4	A0A4Y8D8I3	Zn(2)-C6 fungal-type domain-containing protein.	PALP domain-containing protein.	0.482
A0A4Y8CDD4	A0A4Y8DER3	Zn(2)-C6 fungal-type domain-containing protein.	Acetolactate synthase.	0.704
A0A4Y8CDD4	A0A4Y8DGC3	Zn(2)-C6 fungal-type domain-containing protein.	Uncharacterized protein.	0.482
A0A4Y8CHU2	A0A4Y8CJY3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.422
A0A4Y8CHU2	A0A4Y8CM85	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.939
A0A4Y8CHU2	A0A4Y8CS12	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	ACT domain-containing protein.	0.947
A0A4Y8CHU2	A0A4Y8CYD6	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein.	0.581
A0A4Y8CHU2	A0A4Y8CYK2	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Uncharacterized protein.	0.566
A0A4Y8CHU2	A0A4Y8D2N3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Threonine dehydratase.	0.905
A0A4Y8CHU2	A0A4Y8D7M4	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Pyruvate carboxyltransferase domain-containing protein.	0.671
A0A4Y8CHU2	A0A4Y8D8I3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	PALP domain-containing protein.	0.904
A0A4Y8CHU2	A0A4Y8D9J7	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family.	0.437
A0A4Y8CHU2	A0A4Y8DER3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Acetolactate synthase.	0.950