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glnA glnA pyrD pyrD gltB gltB gltD gltD purN purN purM purM argC argC argA argA argE argE atpD-2 atpD-2 argD argD pyrC pyrC argJ argJ dapA dapA purL purL guaB guaB guaA guaA pyrF pyrF Q91_0671 Q91_0671 Q91_0833 Q91_0833 Q91_0862 Q91_0862 Q91_0889 Q91_0889 hcp hcp purF purF Q91_1171 Q91_1171 Q91_1383 Q91_1383 dapD dapD Q91_1385 Q91_1385 dapE dapE asd asd carB carB carA carA dapB dapB Q91_1512 Q91_1512 Q91_1520 Q91_1520 purA purA glyA glyA Q91_1678 Q91_1678 pyrE pyrE purH purH purD purD Q91_1864 Q91_1864 argG argG argB argB gcvPB gcvPB gcvPA gcvPA gcvH gcvH gcvT gcvT purC purC Q91_2036 Q91_2036 xerC xerC Q91_2069 Q91_2069 dapF dapF lysA lysA Q91_2072 Q91_2072 Q91_2073 Q91_2073 argH argH purE purE Q91_2146 Q91_2146 Q91_2147 Q91_2147 Q91_2148 Q91_2148 pyrB pyrB Q91_2150 Q91_2150 Q91_2151 Q91_2151 Q91_2152 Q91_2152 Q91_2155 Q91_2155 ligB ligB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
glnAGlutamine synthetase, type I. (469 aa)
pyrDDihydroorotate dehydrogenase 1; Catalyzes the conversion of dihydroorotate to orotate. (309 aa)
gltBGlutamate synthase. (1489 aa)
gltDGlutamate synthase, small subunit. (472 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (212 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (345 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase 1; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa)
argAN-alpha-acetylglutamate synthase (Amino-acid acetyltransferase); Belongs to the acetyltransferase family. ArgA subfamily. (517 aa)
argEAcetylornithine deacetylase ArgE, Metallo peptidase, MEROPS family M20A. (378 aa)
atpD-2Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (301 aa)
argDAcetylornithine aminotransferase 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa)
pyrCDihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (343 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa)
dapADihydrodipicolinate synthase subfamily protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1285 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
guaABifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (529 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (248 aa)
Q91_0671Dihydrodipicolinate synthetase; Belongs to the DapA family. (320 aa)
Q91_0833Hypoxanthine phosphoribosyltransferase transmembrane protein. (196 aa)
Q91_0862Aspartokinase; Belongs to the aspartokinase family. (406 aa)
Q91_0889Amino acid kinase family protein. (477 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (556 aa)
purFGlutamine amidotransferase class-II:Phosphoribosyl transferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa)
Q91_1171Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (459 aa)
Q91_1383Aminotransferase, classes I and II superfamily. (398 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (272 aa)
Q91_1385Arsenate reductase; Belongs to the ArsC family. (116 aa)
dapESuccinyl-diaminopimelate desuccinylase 1; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa)
carBCarbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1071 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (377 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa)
Q91_1512Aminotransferase class V. (393 aa)
Q91_15205'-nucleotidase superfamily. (299 aa)
purAAdenylosuccinate synthetase 1; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
glyASerine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
Q91_1678Glutamate dehydrogenase. (1612 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
purHIMP cyclohydrolase / Phosphoribosylaminoimidazolecarboxamide formyltransferase. (520 aa)
purDPhosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Belongs to the GARS family. (428 aa)
Q91_1864Hydrolase, haloacid dehalogenase-like family. (217 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (297 aa)
gcvPBGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa)
gcvPAGlycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (454 aa)
gcvHGlycine cleavage complex protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTGlycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (296 aa)
Q91_2036Glutamate synthase domain 2; Belongs to the glutamate synthase family. (507 aa)
xerCTyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (302 aa)
Q91_2069Hypothetical protein. (234 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (423 aa)
Q91_2072Hypothetical protein. (39 aa)
Q91_2073Phospholipase/Carboxylesterase family. (223 aa)
argHArgininosuccinate lyase 2. (463 aa)
purEPhosphoribosylaminoimidazole carboxylase carboxyltransferase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa)
Q91_2146VanZ family protein. (120 aa)
Q91_2147Dihydroorotate oxidase B, electron transfer subunit. (291 aa)
Q91_2148Aspartate carbamoyltransferase non-catalytic chain. (423 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (337 aa)
Q91_2150Uracil phosphoribosyltransferase / Pyrimidine operon regulatory protein PyrR. (170 aa)
Q91_2151Holliday junction resolvase YqgF; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (141 aa)
Q91_2152Hypothetical protein; Belongs to the UPF0301 (AlgH) family. (187 aa)
Q91_2155Hypothetical protein. (351 aa)
ligBAromatic ring-opening dioxygenase catalytic subunit LigB. (269 aa)
Your Current Organism:
Cycloclasticus sp. P1
NCBI taxonomy Id: 385025
Other names: C. sp. P1
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