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Q91_2109 Q91_2109 Q91_1121 Q91_1121 Q91_1120 Q91_1120 Q91_1119 Q91_1119 Q91_1094 Q91_1094 Q91_1093 Q91_1093 pyrH pyrH Q91_0889 Q91_0889 Q91_0862 Q91_0862 Q91_0846 Q91_0846 lpxK lpxK barA barA Q91_0821 Q91_0821 Q91_0809 Q91_0809 Q91_0807 Q91_0807 Q91_0742 Q91_0742 Q91_0732 Q91_0732 Q91_0714 Q91_0714 cmk cmk Q91_0626 Q91_0626 ndk ndk Q91_0568 Q91_0568 proB proB Q91_0486 Q91_0486 Q91_0484 Q91_0484 Q91_0482 Q91_0482 Q91_0451 Q91_0451 Q91_0429 Q91_0429 Q91_0428 Q91_0428 Q91_0411 Q91_0411 coaE coaE coaX coaX phoR phoR Q91_0295 Q91_0295 anmK, anmK, thrB thrB hldE hldE folK-2 folK-2 aroK aroK ntrB ntrB Q91_0006 Q91_0006 Q91_2130 Q91_2130 Q91_1128 Q91_1128 phoQ phoQ Q91_1323 Q91_1323 tmk tmk adk adk Q91_1427 Q91_1427 Q91_1431 Q91_1431 pckA pckA nadK nadK Q91_1489 Q91_1489 slyX slyX Q91_1510 Q91_1510 ppsA ppsA Q91_1568 Q91_1568 thiL thiL ppk ppk prs prs ispE ispE Q91_1764 Q91_1764 Q91_1766 Q91_1766 Q91_1767 Q91_1767 Q91_1775 Q91_1775 Q91_1780 Q91_1780 spoT spoT gmk gmk Q91_1835 Q91_1835 Q91_1872 Q91_1872 Q91_1895 Q91_1895 argB argB Q91_1951 Q91_1951 cysC cysC Q91_1989 Q91_1989 Q91_2011 Q91_2011 pfp pfp pgk pgk dgkA dgkA Q91_2081 Q91_2081
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Q91_2109ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (715 aa)
Q91_1121Response regulator. (141 aa)
Q91_1120Sensor histidine kinase. (176 aa)
Q91_1119Sensor histidine kinase. (393 aa)
Q91_1094Response regulator receiver modulated diguanylate phosphodiesterase. (555 aa)
Q91_1093Signal transduction histidine kinase. (1140 aa)
pyrHUridylate kinase protein; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
Q91_0889Amino acid kinase family protein. (477 aa)
Q91_0862Aspartokinase; Belongs to the aspartokinase family. (406 aa)
Q91_0846Tetraacyldisaccharide 4'-kinase; Belongs to the UPF0434 family. (63 aa)
lpxKTetraacyldisaccharide 4' kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (321 aa)
barAHistidine kinase; Response regulator receiver:ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A. (771 aa)
Q91_0821ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (441 aa)
Q91_0809Protein phosphatase 2C-like protein. (567 aa)
Q91_0807Protein phosphatase 2C-like protein. (573 aa)
Q91_0742Pyruvate kinase II; Belongs to the pyruvate kinase family. (479 aa)
Q91_0732Cyclic diguanylate phosphodiesterase domain protein. (612 aa)
Q91_0714ATP-binding region, ATPase-like:Histidine kinase A. (395 aa)
cmk3-phosphoshikimate 1-carboxyvinyltransferase. (224 aa)
Q91_0626Response regulator receiver modulated diguanylate cyclase/phosphodiesterase. (1475 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
Q91_0568Riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (312 aa)
proBGlutamate 5-kinase, bacterial form; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa)
Q91_0486Hybrid histidine kinase. (797 aa)
Q91_0484ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (449 aa)
Q91_0482Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor. (1012 aa)
Q91_0451ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (926 aa)
Q91_04297, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (167 aa)
Q91_0428Deoxynucleoside kinase family protein. (221 aa)
Q91_0411Putative exported 24-amino acid repeat protein. (121 aa)
coaEDephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa)
coaXTranscriptional activator, Bvg accessory factor family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (245 aa)
phoRPAS:ATP-binding region, ATPase-like:Histidine kinase A. (434 aa)
Q91_0295ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (543 aa)
anmK,Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (366 aa)
thrBHomoserine kinase; Belongs to the pseudomonas-type ThrB family. (314 aa)
hldEBifunctional protein HldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (477 aa)
folK-27, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase. (163 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
ntrBATP-binding region, ATPase-like:Histidine kinase A. (356 aa)
Q91_0006Aliphatic amidase expression-regulating protein. (428 aa)
Q91_2130Cyclic diguanylate phosphodiesterase domain protein. (813 aa)
Q91_1128Response regulator/GGDEF domain protein. (571 aa)
phoQATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein. (451 aa)
Q91_1323ATP-binding region, ATPase-like:Histidine kinase, HAMP region:Histidine kinase A. (329 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (209 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
Q91_1427Diguanylate cyclase. (1487 aa)
Q91_1431Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor. (809 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (534 aa)
nadKNAD(+)/NADH kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (294 aa)
Q91_1489Histidine kinase. (426 aa)
slyXSlyX family protein; Belongs to the SlyX family. (68 aa)
Q91_1510Phosphotransferase; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (273 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (800 aa)
Q91_1568Two-component sensor histidine kinase. (426 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (318 aa)
ppkPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (689 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
ispE4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (297 aa)
Q91_1764O-antigen polymerase family protein/toluene tolerance protein. (223 aa)
Q91_1766Lipopolysaccharide kinase (Kdo/WaaP) family. (253 aa)
Q91_1767Hypothetical protein. (272 aa)
Q91_1775Mn2+dependent serine/threonine protein kinase. (478 aa)
Q91_1780Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor. (633 aa)
spoTppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (720 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)
Q91_1835Cell cycle protein kinase CDC5/MSD2. (303 aa)
Q91_1872Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor. (669 aa)
Q91_1895Phosphomethylpyrimidine kinase. (267 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (297 aa)
Q91_1951Sugar kinase transferase, PfkB. (331 aa)
cysCSulfate adenylyltransferase subunit 1 / adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (197 aa)
Q91_1989Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (241 aa)
Q91_2011Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor. (851 aa)
pfpPhosphofructokinase domain protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (391 aa)
dgkADiacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (119 aa)
Q91_2081Signal transduction protein. (351 aa)
Your Current Organism:
Cycloclasticus sp. P1
NCBI taxonomy Id: 385025
Other names: C. sp. P1
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