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leuA leuA Q91_2248 Q91_2248 Q91_2217 Q91_2217 glmU glmU Q91_2191 Q91_2191 Q91_2162 Q91_2162 Q91_2139 Q91_2139 Q91_1929 Q91_1929 aceF aceF bioF bioF Q91_1802 Q91_1802 Q91_1772 Q91_1772 lipB lipB lnt lnt Q91_1504 Q91_1504 lapG lapG Q91_1424 Q91_1424 Q91_1423 Q91_1423 Q91_1420 Q91_1420 dapD dapD fabH-1 fabH-1 Q91_1371 Q91_1371 Q91_1370 Q91_1370 Q91_1368 Q91_1368 waaM waaM Q91_1261 Q91_1261 Q91_1233 Q91_1233 Q91_1228 Q91_1228 Q91_1217 Q91_1217 Q91_1205 Q91_1205 Q91_1187 Q91_1187 Q91_1183 Q91_1183 Q91_1172 Q91_1172 aceB aceB bpt bpt aat aat lpxA-2 lpxA-2 fabZ fabZ lpxD lpxD Q91_0927 Q91_0927 ectA ectA ompW ompW Q91_0697 Q91_0697 plsB plsB fabV fabV Q91_0522 Q91_0522 Q91_0519 Q91_0519 fabA fabA Q91_0510 Q91_0510 Q91_0479 Q91_0479 Q91_0417 Q91_0417 phaC, phaC, argJ argJ Q91_0333 Q91_0333 argA argA Q91_0262 Q91_0262 Q91_0212 Q91_0212 tsaD tsaD Q91_0050 Q91_0050 metX metX Q91_0019 Q91_0019
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
leuA2-isopropylmalate synthase 1 protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa)
Q91_2248Transglutaminase domain protein. (644 aa)
Q91_2217Acetyltransferase, GNAT family. (139 aa)
glmUN-acetylglucosamine-1-phosphate uridyltransferase / Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa)
Q91_2191Thiolase/acyl transferase. (387 aa)
Q91_2162Glutamyl-tRNA synthetase. (185 aa)
Q91_2139Acyltransferase domain protein. (571 aa)
Q91_1929Putative acyl-CoA N-acyltransferase. (384 aa)
aceFDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (533 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
Q91_1802Gamma-glutamyltransferase 1, Threonine peptidase, MEROPS family T03. (567 aa)
Q91_1772Membrane bound O-acyl transferase MBOAT family protein; Belongs to the membrane-bound acyltransferase family. (484 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (223 aa)
lntApolipoprotein N-acyltransferase, copper homeostasis protein; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily. (506 aa)
Q91_1504PHA synthase subunit PhaC. (348 aa)
lapG4-hydroxy-2-oxovalerate aldolase 1; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (356 aa)
Q91_1424Hypothetical protein. (266 aa)
Q91_1423Citrate synthase-like protein. (275 aa)
Q91_1420Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (418 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (272 aa)
fabH-13-oxoacyl-[acyl-carrier-protein] synthase III, acetylCoA ACP transacylase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamil [...] (320 aa)
Q91_1371Malonyl CoA-acyl carrier protein transacylase. (312 aa)
Q91_13703-oxoacyl-(Acyl carrier protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa)
Q91_13683-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa)
waaMLipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase superfamily protein. (292 aa)
Q91_1261Serine O-acetyltransferase. (262 aa)
Q91_1233Acetyl-coa acetyltransferase protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Q91_1228MaoC-like dehydratase. (137 aa)
Q91_1217acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
Q91_1205Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
Q91_1187Citrate synthase I. (259 aa)
Q91_1183Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
Q91_1172Acetyltransferase, GNAT family protein. (172 aa)
aceBMalate synthase A. (527 aa)
bptArginyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily. (257 aa)
aatLeucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. (230 aa)
lpxA-2Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosam ine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa)
fabZBeta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase, LpxD; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (340 aa)
Q91_0927Lipid A biosynthesis lauroyl acyltransferase subfamily. (305 aa)
ectAHistone acetyltransferase HPA2/related acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (119 aa)
ompWOmpW family. (221 aa)
Q91_06973-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (378 aa)
plsBGlycerol-3-phosphate o-acyltransferase protein; Belongs to the GPAT/DAPAT family. (799 aa)
fabVShort-chain alcohol dehydrogenase family; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (403 aa)
Q91_0522Malate dehydrogenase, Phosphate acetyltransferase. (755 aa)
Q91_05193-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (405 aa)
fabABeta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (174 aa)
Q91_05104-hydroxy-2-oxovalerate aldolase NahM; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (341 aa)
Q91_0479Poly-beta-hydroxybutyrate polymerase domain protein. (583 aa)
Q91_0417Acetyl-CoA acetyltransferase / 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
phaC,Poly-beta-hydroxybutyrate polymerase transmembrane protein. (574 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa)
Q91_03332-isopropylmalate synthase LeuA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (500 aa)
argAN-alpha-acetylglutamate synthase (Amino-acid acetyltransferase); Belongs to the acetyltransferase family. ArgA subfamily. (517 aa)
Q91_0262Methylcitrate synthase; Belongs to the citrate synthase family. (375 aa)
Q91_0212Peptide n-acetyltransferase RimI. (166 aa)
tsaDO-sialoglycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (344 aa)
Q91_0050Citrate synthase I; Belongs to the citrate synthase family. (430 aa)
metXHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (379 aa)
Q91_0019Phospholipid and glycerol acyltransferase. (249 aa)
Your Current Organism:
Cycloclasticus sp. P1
NCBI taxonomy Id: 385025
Other names: C. sp. P1
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