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| | metH | 5-methyltetrahydrofolate--homocysteine methyltransferase, MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1237 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | aceF | Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (533 aa) |
| | aceE | Pyruvate dehydrogenase, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (892 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (297 aa) |
| | Q91_1913 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (414 aa) |
| | argS | Arginyl-tRNA synthetase. (585 aa) |
| | gcvPB | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa) |
| | gcvPA | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (454 aa) |
| | gcvH | Glycine cleavage complex protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvT | Glycine cleavage system aminomethyltransferase T; The glycine cleavage system catalyzes the degradation of glycine. (363 aa) |
| | pgi | Glucose-6-phosphate isomerase 2; Belongs to the GPI family. (541 aa) |
| | Q91_0021 | Glycyl-tRNA synthetase beta subunit. (161 aa) |
| | bioA | Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (440 aa) |
| | trpC | Indole-3-glycerol phosphate synthase protein; Belongs to the TrpC family. (265 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | trpE | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (500 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (230 aa) |
| | pfp | Phosphofructokinase domain protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa) |
| | Q91_2036 | Glutamate synthase domain 2; Belongs to the glutamate synthase family. (507 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (391 aa) |
| | Q91_2057 | Aromatic-ring-hydroxylating dioxygenase, beta subunit. (177 aa) |
| | Q91_2062 | Sterol-binding domain protein. (207 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (275 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (423 aa) |
| | argH | Argininosuccinate lyase 2. (463 aa) |
| | Q91_2084 | Uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (247 aa) |
| | aroE | Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (270 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (220 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (244 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (129 aa) |
| | hisE | Phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase. (105 aa) |
| | Q91_2144 | FAD dependent oxidoreductase. (360 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (337 aa) |
| | Q91_2158 | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (282 aa) |
| | Q91_2164 | Beta-lactamase domain protein. (304 aa) |
| | Q91_2184 | Nucleotide sugar dehydrogenase subfamily. (391 aa) |
| | Q91_2191 | Thiolase/acyl transferase. (387 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa) |
| | phnA3 | PAH dioxygenase component ferredoxin. (104 aa) |
| | acsA | Acetyl-coenzyme A synthetase 2; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (646 aa) |
| | proB | Glutamate 5-kinase, bacterial form; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (937 aa) |
| | Q91_0575 | Oxidoreductase, FAD-binding protein. (460 aa) |
| | hisS | Histidyl-tRNA synthetase. (421 aa) |
| | guaA | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (529 aa) |
| | fbaA | Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa) |
| | Q91_0639 | Peptidase dimerization domain protein. (366 aa) |
| | Q91_0649 | Succinylglutamate desuccinylase / Aspartoacylase family. (353 aa) |
| | Q91_0671 | Dihydrodipicolinate synthetase; Belongs to the DapA family. (320 aa) |
| | Q91_0672 | Ketopantoate reductase ApbA/PanE; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (337 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa) |
| | Q91_0684 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein. (387 aa) |
| | pheA | Prephenate dehydratase domain protein. (360 aa) |
| | hisC | Histidinol-phosphate aminotransferase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (373 aa) |
| | tyrA | Prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase family protein. (289 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (433 aa) |
| | Q91_0696 | 3-hydroxyacyl-CoA dehydrogenase. (774 aa) |
| | Q91_0697 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (378 aa) |
| | Q91_0698 | Long-chain-fatty-acid-CoA-ligase RpfB. (553 aa) |
| | Q91_0700 | Phenylacetate degradation, enoyl-CoA hydratase PaaB. (275 aa) |
| | Q91_0709 | Alanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (364 aa) |
| | yafJ | Glutamine amidotransferase class-II. (152 aa) |
| | Q91_0730 | Amidotransferase YafJ-like protein. (55 aa) |
| | Q91_0740 | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (406 aa) |
| | Q91_0742 | Pyruvate kinase II; Belongs to the pyruvate kinase family. (479 aa) |
| | glnS | Glutamyl-tRNA synthetase, class Ic. (559 aa) |
| | Q91_0769 | Aminotransferase, classes I and II superfamily. (396 aa) |
| | trpB-2 | Tryptophan synthase b subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (392 aa) |
| | thrS | Threonyl-tRNA synthetase, class IIa; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (639 aa) |
| | pheS | Phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (339 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (792 aa) |
| | Q91_0814 | Assimilatory nitrate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (733 aa) |
| | Q91_0817 | Long-chain acyl-CoA synthetase. (487 aa) |
| | Q91_0818 | Carbamoylphosphate synthase large subunit. (222 aa) |
| | cysM | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (295 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (871 aa) |
| | Q91_0862 | Aspartokinase; Belongs to the aspartokinase family. (406 aa) |
| | Q91_0877 | Alcohol dehydrogenase, zinc-binding domain protein. (343 aa) |
| | Q91_0890 | Phytanoyl-CoA deoxygenase family protein. (314 aa) |
| | ectC | Ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant. (139 aa) |
| | ectB | 4-aminobutyrate aminotransferase and related aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (430 aa) |
| | ectA | Histone acetyltransferase HPA2/related acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A. (119 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (763 aa) |
| | Q91_0933 | Ring hydroxylating dioxygenase beta subunit. (182 aa) |
| | Q91_0951 | Phosphoserine phosphatase SerB. (275 aa) |
| | gltX | Glutamyl-tRNA synthetase 1; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (472 aa) |
| | hcaF | PAH dioxygenase iron sulfur protein small subunit. (178 aa) |
| | Q91_1006 | Fe-S oxidoreductase of MoaA/nifB/pqqE family. (317 aa) |
| | dxr | 1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (392 aa) |
| | fabZ | Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (149 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (548 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (277 aa) |
| | eno | Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (426 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (238 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa) |
| | Q91_1043 | Homoserine dehydrogenase. (436 aa) |
| | Q91_1044 | Threonine synthase, pyridoxal-5'-phosphate-dependent enzyme; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (380 aa) |
| | csdB | Aminotransferase, class V; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (413 aa) |
| | lysS | Lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (502 aa) |
| | Q91_1061 | Hypothetical protein. (53 aa) |
| | Q91_1066 | TPR repeat protein. (78 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (209 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (403 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (307 aa) |
| | folC | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. (424 aa) |
| | purF | Glutamine amidotransferase class-II:Phosphoribosyl transferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa) |
| | metZ | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (396 aa) |
| | cysS | Cysteinyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (463 aa) |
| | Q91_1143 | Fumarylacetoacetate hydrolase family protein. (282 aa) |
| | hisI2 | Phosphoribosyl-AMP cyclohydrolase domain protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (140 aa) |
| | Q91_1157 | Dihydrodipicolinate synthetase; Belongs to the DapA family. (332 aa) |
| | Q91_1158 | Alanine dehydrogenase and pyridine nucleotide transhydrogenase. (353 aa) |
| | icl | Isocitrate lyase family protein. (532 aa) |
| | aceB | Malate synthase A. (527 aa) |
| | Q91_1183 | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa) |
| | Q91_1188 | Monoamine oxidase regulatory protein. (141 aa) |
| | Q91_1189 | MaoC domain protein dehydratase. (142 aa) |
| | Q91_1190 | Metallo-beta-lactamase superfamily. (338 aa) |
| | Q91_1193 | MmgE/PrpD family protein. (462 aa) |
| | Q91_1205 | Beta-ketothiolase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa) |
| | Q91_1214 | Acyl dehydratase-like protein. (341 aa) |
| | Q91_1217 | acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa) |
| | Q91_1219 | Geranyl-CoA carboxylase, alpha-subunit. (656 aa) |
| | accB1 | Acetyl-CoA carboxylase carboxyltransferase. (539 aa) |
| | Q91_1226 | Enoyl-CoA hydratase / short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (267 aa) |
| | Q91_1227 | 4-hydroxybutyrate CoA transferase. (443 aa) |
| | Q91_1228 | MaoC-like dehydratase. (137 aa) |
| | Q91_1232 | Acyl-CoA dehydrogenase. (386 aa) |
| | Q91_1233 | Acetyl-coa acetyltransferase protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | Q91_1234 | Acetyl/propionyl-CoA carboxylase,carboxyltransferase subunit. (535 aa) |
| | Q91_1235 | Methylcrotonoyl-CoA carboxylase subunit alpha. (667 aa) |
| | Q91_1236 | Hydroxymethylglutaryl-CoA lyase. (299 aa) |
| | Q91_1239 | Zn-dependent hydrolase or glyoxylase,metallo-beta-lactamase superfamily protein. (252 aa) |
| | acd5 | Acyl-CoA dehydrogenase domain protein. (380 aa) |
| | Q91_1245 | Enoyl-CoA hydratase / short chain enoyl-CoA hydratase. (266 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa) |
| | Q91_1261 | Serine O-acetyltransferase. (262 aa) |
| | Q91_1315 | Glyoxalase family protein. (168 aa) |
| | maoC | Hydratase, contains MaoC-like domain. (152 aa) |
| | Q91_1349 | Aminotransferase, class V. (379 aa) |
| | ispG, | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (406 aa) |
| | cysZ | Sulfate transporter CysZ-type; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. (243 aa) |
| | Q91_1366 | Aminotransferase, class IV superfamily. (285 aa) |
| | Q91_1368 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (412 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (78 aa) |
| | Q91_1370 | 3-oxoacyl-(Acyl carrier protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (243 aa) |
| | Q91_1371 | Malonyl CoA-acyl carrier protein transacylase. (312 aa) |
| | fabH-1 | 3-oxoacyl-[acyl-carrier-protein] synthase III, acetylCoA ACP transacylase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamil [...] (320 aa) |
| | gloA | Glyoxalase I. (125 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (272 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase 1; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (375 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa) |
| | Q91_1420 | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (418 aa) |
| | Q91_1422 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (610 aa) |
| | Q91_1441 | Formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (904 aa) |
| | mdh | Malate dehydrogenase 1; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | folP | Dihydropteroate synthase. (259 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family. (1071 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (377 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa) |
| | leuA | 2-isopropylmalate synthase 1 protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (517 aa) |
| | lapG | 4-hydroxy-2-oxovalerate aldolase 1; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (356 aa) |
| | slyX | SlyX family protein; Belongs to the SlyX family. (68 aa) |
| | Q91_1500 | Aminotransferase class I and II. (391 aa) |
| | gluQ | Glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (300 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (800 aa) |
| | poxA | Lysyl-tRNA synthetase GenX. (324 aa) |
| | Q91_1517 | Lysine 2,3-aminomutase YodO family protein. (343 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (357 aa) |
| | icmF | Adenosyl-cobalamine enzyme; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1090 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (390 aa) |
| | Q91_1563 | Diadenosine tetraphosphate (Ap4A) hydrolase-like HIT family hydrolase. (114 aa) |
| | Q91_1570 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (743 aa) |
| | glyA | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | Q91_1615 | Cysteine synthase A. (342 aa) |
| | Q91_1616 | Pyridoxal-dependent decarboxylase. (480 aa) |
| | Q91_1625 | Thioesterase superfamily protein. (147 aa) |
| | Q91_1626 | AMP-dependent synthetase and ligase. (513 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (209 aa) |
| | proA | Gamma-glutamyl phosphate reductase GPR; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (419 aa) |
| | leuS | Leucyl-tRNA synthetase, class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family. (816 aa) |
| | Q91_1678 | Glutamate dehydrogenase. (1612 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (297 aa) |
| | Q91_1752 | Aminotransferase, class IV superfamily. (288 aa) |
| | Q91_2243 | Aromatic-ring-hydroxylating dioxygenase, beta subunit. (177 aa) |
| | phnA2 | PAH dioxygenase iron sulfur protein small subunit. (177 aa) |
| | fabV | Short-chain alcohol dehydrogenase family; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (403 aa) |
| | Q91_0522 | Malate dehydrogenase, Phosphate acetyltransferase. (755 aa) |
| | Q91_0519 | 3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (405 aa) |
| | fabA | Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (174 aa) |
| | Q91_0516 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (319 aa) |
| | Q91_0510 | 4-hydroxy-2-oxovalerate aldolase NahM; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (341 aa) |
| | Q91_0494 | FAD linked oxidase domain protein. (522 aa) |
| | Q91_0490 | FAD linked oxidase domain protein. (478 aa) |
| | pqqB | Beta-lactamase superfamily I metal-dependent hydrolase; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family. (302 aa) |
| | pqqC | Pyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (241 aa) |
| | pqqD | Coenzyme PQQ synthesis protein D. (91 aa) |
| | pqqE | Quinoprotein ethanol dehydrogenase, PQQ dehydrogenase family; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (315 aa) |
| | Q91_0454 | Glycine oxidase ThiO. (360 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1285 aa) |
| | Q91_0439 | Beta-lactamase domain protein. (238 aa) |
| | dapA | Dihydrodipicolinate synthase subfamily protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa) |
| | Q91_0429 | 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (167 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase 2; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (270 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (283 aa) |
| | panD | Aspartate 1-decarboxylase alpha chain; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (312 aa) |
| | Q91_0417 | Acetyl-CoA acetyltransferase / 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa) |
| | valS | Valyl-tRNA synthetase, class Ia; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (874 aa) |
| | argJ | Bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (406 aa) |
| | Q91_0345 | FMN-dependent dehydrogenase superfamily. (372 aa) |
| | Q91_0334 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. (368 aa) |
| | Q91_0333 | 2-isopropylmalate synthase LeuA; Belongs to the alpha-IPM synthase/homocitrate synthase family. (500 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (204 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa) |
| | nadA | Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (362 aa) |
| | aspS | Aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (595 aa) |
| | argD | Acetylornithine aminotransferase 1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa) |
| | atpD-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (301 aa) |
| | ilvD | Dihydroxy-acid dehydratase 2; Belongs to the IlvD/Edd family. (564 aa) |
| | argE | Acetylornithine deacetylase ArgE, Metallo peptidase, MEROPS family M20A. (378 aa) |
| | argA | N-alpha-acetylglutamate synthase (Amino-acid acetyltransferase); Belongs to the acetyltransferase family. ArgA subfamily. (517 aa) |
| | Q91_0265 | Metallo-beta-lactamase superfamily protein. (313 aa) |
| | Q91_0264 | AMP-dependent synthetase and ligase. (632 aa) |
| | prpB | PEP phosphonomutase and related enzyme; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (294 aa) |
| | prpF | AcnD-accessory protein PrpF. (392 aa) |
| | tyrS | Tyrosyl-tRNA synthetase, class Ib; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (400 aa) |
| | anmK, | Anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (366 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase 1; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa) |
| | proS | Prolyl-tRNA synthetase, family II; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and i [...] (570 aa) |
| | Q91_0221 | Metallo-beta-lactamase family protein. (234 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | ilvN | Acetolactate synthase, small subunit. (164 aa) |
| | ilvB | Acetolactate synthase, large subunit, biosynthetic type. (576 aa) |
| | thrB | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. (314 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (150 aa) |
| | metG | Methionyl-tRNA synthetase, class Ia; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (677 aa) |
| | Q91_0121 | Glutamine amidotransferase class-I. (231 aa) |
| | folB | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (119 aa) |
| | folK-2 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase. (163 aa) |
| | aroG2 | Phospho-2-dehydro-3-deoxyheptonate aldolase,Phe-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (359 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (275 aa) |
| | gltB | Glutamate synthase. (1489 aa) |
| | aroB | Dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa) |
| | metX | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (379 aa) |
| | Q91_0042 | Nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like protein; Nitrite and sulphite reductase 4Fe-4S region; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (547 aa) |
| | pgm | Phosphoglycerate mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (517 aa) |
| | glnA | Glutamine synthetase, type I. (469 aa) |
| | glyQ | Glycyl-tRNA synthetase alpha subunit. (326 aa) |
| | lipA | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (324 aa) |
| | Q91_1772 | Membrane bound O-acyl transferase MBOAT family protein; Belongs to the membrane-bound acyltransferase family. (484 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (306 aa) |
| | bphA2 | Iron sulfur protein small subunit. (191 aa) |
| | hpaI | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, with PEP/pyruvate domain; Belongs to the HpcH/HpaI aldolase family. (258 aa) |
| | bioD | Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (232 aa) |
| | bioC | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (271 aa) |
| | bioH | pimeloyl-BioC--CoA transferase BioH. (238 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa) |
| | bioB | Biotin synthase, contains an iron-sulfur cluster and PLP; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa) |
| | ubiC | Chorismate:pyruvate lyase, 4-hydroxybenzoate synthetase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (160 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa) |
| | accB2 | Acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (149 aa) |
| | Q91_1854 | Biotin carboxylase / acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa) |
| | Q91_1878 | Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (160 aa) |
