(14 nodes) Helicase, C-terminal network (Cycloclasticus sp. P1)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Your Input:
	Q91_0087	ATP-dependent helicase HrpA. (1298 aa)
	secA	Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (884 aa)
	rhlE	ATP-dependent RNA helicase RhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (442 aa)
	uvrB	Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (666 aa)
	mfd	Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1101 aa)
	Q91_1130	Restriction enzymes type I helicase. (965 aa)
	Q91_1133	Helicase conserved domain protein. (701 aa)
	deaD-1	ATP-dependent RNA helicase DeaD-like protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (594 aa)
	hepA	ATPase associated with RNA polymerase and transcriptional activator; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (948 aa)
	recG	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (693 aa)
	rhlB	DEAD/DEAH box helicase domain-containing protein; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (420 aa)
	priA	Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (733 aa)
	Q91_2138	RNA helicase DbpA; Belongs to the DEAD box helicase family. (460 aa)
	Q91_2141	ATP-dependent DNA helicase RecQ. (704 aa)

Your Current Organism:

Cycloclasticus sp. P1

NCBI taxonomy Id: 385025
Other names: C. sp. P1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Q91_0087	Q91_1133	Q91_0087	Q91_1133	ATP-dependent helicase HrpA.	Helicase conserved domain protein.	0.796
Q91_0087	Q91_2138	Q91_0087	Q91_2138	ATP-dependent helicase HrpA.	RNA helicase DbpA; Belongs to the DEAD box helicase family.	0.629
Q91_0087	deaD-1	Q91_0087	Q91_1493	ATP-dependent helicase HrpA.	ATP-dependent RNA helicase DeaD-like protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.	0.629
Q91_0087	rhlB	Q91_0087	Q91_1863	ATP-dependent helicase HrpA.	DEAD/DEAH box helicase domain-containing protein; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.	0.629
Q91_0087	rhlE	Q91_0087	Q91_0599	ATP-dependent helicase HrpA.	ATP-dependent RNA helicase RhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA.	0.629
Q91_1130	Q91_1133	Q91_1130	Q91_1133	Restriction enzymes type I helicase.	Helicase conserved domain protein.	0.785
Q91_1133	Q91_0087	Q91_1133	Q91_0087	Helicase conserved domain protein.	ATP-dependent helicase HrpA.	0.796
Q91_1133	Q91_1130	Q91_1133	Q91_1130	Helicase conserved domain protein.	Restriction enzymes type I helicase.	0.785
Q91_1133	Q91_2138	Q91_1133	Q91_2138	Helicase conserved domain protein.	RNA helicase DbpA; Belongs to the DEAD box helicase family.	0.404
Q91_1133	deaD-1	Q91_1133	Q91_1493	Helicase conserved domain protein.	ATP-dependent RNA helicase DeaD-like protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.	0.404
Q91_1133	rhlB	Q91_1133	Q91_1863	Helicase conserved domain protein.	DEAD/DEAH box helicase domain-containing protein; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.	0.404
Q91_1133	rhlE	Q91_1133	Q91_0599	Helicase conserved domain protein.	ATP-dependent RNA helicase RhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA.	0.404
Q91_2138	Q91_0087	Q91_2138	Q91_0087	RNA helicase DbpA; Belongs to the DEAD box helicase family.	ATP-dependent helicase HrpA.	0.629
Q91_2138	Q91_1133	Q91_2138	Q91_1133	RNA helicase DbpA; Belongs to the DEAD box helicase family.	Helicase conserved domain protein.	0.404
Q91_2138	hepA	Q91_2138	Q91_1509	RNA helicase DbpA; Belongs to the DEAD box helicase family.	ATPase associated with RNA polymerase and transcriptional activator; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.	0.455
Q91_2141	deaD-1	Q91_2141	Q91_1493	ATP-dependent DNA helicase RecQ.	ATP-dependent RNA helicase DeaD-like protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.	0.922
Q91_2141	hepA	Q91_2141	Q91_1509	ATP-dependent DNA helicase RecQ.	ATPase associated with RNA polymerase and transcriptional activator; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.	0.810
Q91_2141	recG	Q91_2141	Q91_1829	ATP-dependent DNA helicase RecQ.	ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.	0.571
deaD-1	Q91_0087	Q91_1493	Q91_0087	ATP-dependent RNA helicase DeaD-like protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.	ATP-dependent helicase HrpA.	0.629
deaD-1	Q91_1133	Q91_1493	Q91_1133	ATP-dependent RNA helicase DeaD-like protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.	Helicase conserved domain protein.	0.404