STRINGSTRING
IRF3 IRF3 MALT1 MALT1 TRAF6 TRAF6 LOC102370354 LOC102370354 LOC102378124 LOC102378124 LOC102368346 LOC102368346 TNIP3 TNIP3 LOC102371292 LOC102371292 NFKBIA NFKBIA TLR2 TLR2 IRF7 IRF7 PRKCQ PRKCQ TANK TANK LOC102375359 LOC102375359 CDC37 CDC37 TRAF3 TRAF3 OTUD4 OTUD4 SPATA2 SPATA2 LY86 LY86 LOC102377887 LOC102377887 CYLD CYLD LOC102373745 LOC102373745 LOC102369457 LOC102369457 DDX58 DDX58 CD180 CD180 TLR7 TLR7 LOC102385936 LOC102385936 LOC102383113 LOC102383113 ZRANB1 ZRANB1 IKBKB IKBKB PP2D1 PP2D1 MAP3K8 MAP3K8 MAP3K9 MAP3K9 IRAK2 IRAK2 LOC102369160 LOC102369160 IKBKG IKBKG PRKCD PRKCD MAP3K14 MAP3K14 SARM1 SARM1 LOC102387718 LOC102387718 OTUD7B OTUD7B TOLLIP TOLLIP LOC102383734 LOC102383734 MAP3K21 MAP3K21 LOC102371494 LOC102371494 MAP3K20 MAP3K20 TNFAIP3 TNFAIP3 LOC102376917 LOC102376917 ASB8 ASB8 LOC102384158 LOC102384158 LOC102384088 LOC102384088 MYD88 MYD88 NOD1 NOD1 NFATC4 NFATC4 ZBTB11 ZBTB11 LOC102384063 LOC102384063 NFKBIB NFKBIB PELI1 PELI1 SACS SACS CARD11 CARD11 IRF6 IRF6 LOC102387656 LOC102387656 TRAF3IP2 TRAF3IP2 RIPK2 RIPK2 MAP3K6 MAP3K6 CHUK CHUK TRAF2 TRAF2 TAX1BP1 TAX1BP1 IKBKE IKBKE IRAK4 IRAK4 LOC102374298 LOC102374298 LY96 LY96 RIPK1 RIPK1 IRAK3 IRAK3 CNPY3 CNPY3 NFKB2 NFKB2 RELB RELB TLR3 TLR3 TBK1 TBK1 REL REL TRAF1 TRAF1 LOC112548286 LOC112548286 LOC112548281 LOC112548281 RNF31 RNF31 ANKRD29 ANKRD29 RELA RELA LOC112548285 LOC112548285 CARD9 CARD9 TAB2 TAB2 TRIM25 TRIM25 LOC112548964 LOC112548964 PELI2 PELI2 TICAM1 TICAM1 NFKBIE NFKBIE MAP3K7 MAP3K7 SETD6 SETD6 TAB3 TAB3 LOC102374052 LOC102374052 LOC102375854 LOC102375854 TNIP1 TNIP1 TLR8 TLR8 TIRAP TIRAP RNF216 RNF216 ZBP1 ZBP1 TMEM173 TMEM173 TNFRSF25 TNFRSF25 LOC102382314 LOC102382314 ANKRD6 ANKRD6 TLR4 TLR4 TLR5 TLR5 SPATA2L SPATA2L TAB1 TAB1 RBCK1 RBCK1 MAP3K10 MAP3K10 IRAK1 IRAK1 TRAF4 TRAF4 LOC102368067 LOC102368067 LOC112551609 LOC112551609 SHARPIN SHARPIN TNFRSF1A TNFRSF1A LOC112551715 LOC112551715 BCL10 BCL10 CLIP4 CLIP4 UNC93B1 UNC93B1 NFKB1 NFKB1 NFKBIZ NFKBIZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRF3Interferon regulatory factor 3 isoform X2. (432 aa)
MALT1Mucosa-associated lymphoid tissue lymphoma translocation protein 1. (770 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
LOC102370354Toll-like receptor 13. (997 aa)
LOC102378124Toll-like receptor 13; Belongs to the Toll-like receptor family. (954 aa)
LOC102368346Toll-like receptor 2 type-2; Belongs to the Toll-like receptor family. (793 aa)
TNIP3TNFAIP3-interacting protein 3 isoform X1. (408 aa)
LOC102371292E3 ubiquitin/ISG15 ligase TRIM25-like isoform X1. (401 aa)
NFKBIANF-kappa-B inhibitor alpha. (316 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (784 aa)
IRF7Interferon regulatory factor 7. (605 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (708 aa)
TANKTRAF family member-associated NF-kappa-B activator isoform X1. (485 aa)
LOC102375359Toll-like receptor 8. (1040 aa)
CDC37Hsp90 co-chaperone Cdc37 isoform X2. (376 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
OTUD4OTU domain-containing protein 4 isoform X1. (1109 aa)
SPATA2Spermatogenesis-associated protein 2. (523 aa)
LY86Lymphocyte antigen 86. (161 aa)
LOC102377887RING finger protein 11-like. (138 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (954 aa)
LOC102373745Toll-like receptor 1; Belongs to the Toll-like receptor family. (801 aa)
LOC102369457RING finger protein 151-like. (288 aa)
DDX58Probable ATP-dependent RNA helicase DDX58 isoform X1. (928 aa)
CD180LOW QUALITY PROTEIN: CD180 antigen. (662 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
LOC102385936Uncharacterized protein LOC102385936. (597 aa)
LOC102383113Toll-like receptor 2. (875 aa)
ZRANB1LOW QUALITY PROTEIN: ubiquitin thioesterase ZRANB1. (714 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta. (757 aa)
PP2D1Protein phosphatase 2C-like domain-containing protein 1. (665 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (1095 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (732 aa)
LOC102369160Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
IKBKGNF-kappa-B essential modulator. (534 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (685 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (938 aa)
SARM1Sterile alpha and TIR motif-containing protein 1. (718 aa)
LOC102387718Toll-like receptor 5. (538 aa)
OTUD7BOTU domain-containing protein 7B. (866 aa)
TOLLIPToll-interacting protein isoform X1. (274 aa)
LOC102383734Toll-like receptor 2. (439 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase 21 isoform X1. (833 aa)
LOC102371494Toll-like receptor 1. (652 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20 isoform X3. (807 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (817 aa)
LOC102376917TNF receptor-associated factor 1-like. (328 aa)
ASB8Ankyrin repeat and SOCS box protein 8 isoform X1. (284 aa)
LOC102384158Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (846 aa)
LOC102384088Interferon regulatory factor 6 isoform X1. (465 aa)
MYD88Myeloid differentiation primary response protein MyD88. (211 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (951 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (831 aa)
ZBTB11Zinc finger and BTB domain-containing protein 11 isoform X1. (945 aa)
LOC102384063Toll-like receptor 2; Belongs to the Toll-like receptor family. (837 aa)
NFKBIBNF-kappa-B inhibitor beta. (179 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog 1. (418 aa)
SACSLOW QUALITY PROTEIN: sacsin. (4504 aa)
CARD11Caspase recruitment domain-containing protein 11 isoform X1. (1207 aa)
IRF6Interferon regulatory factor 6 isoform X1. (493 aa)
LOC102387656Toll-like receptor 13. (969 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (557 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2. (510 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6 isoform X1. (1199 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (735 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (553 aa)
TAX1BP1Tax1-binding protein 1. (817 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (468 aa)
LOC102374298Receptor-interacting serine/threonine-protein kinase 2-like. (565 aa)
LY96Lymphocyte antigen 96 isoform X1. (192 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (711 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (136 aa)
CNPY3Protein canopy homolog 3. (282 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (903 aa)
RELBTranscription factor RelB. (614 aa)
TLR3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
TBK1Serine/threonine-protein kinase TBK1 isoform X1. (741 aa)
RELProto-oncogene c-Rel. (607 aa)
TRAF1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
LOC112548286Uncharacterized protein LOC112548286. (456 aa)
LOC112548281TNF receptor-associated factor 6-like. (213 aa)
RNF31E3 ubiquitin-protein ligase RNF31. (930 aa)
ANKRD29Ankyrin repeat domain-containing protein 29 isoform X1. (322 aa)
RELATranscription factor p65. (554 aa)
LOC112548285Uncharacterized protein LOC112548285. (484 aa)
CARD9Caspase recruitment domain-containing protein 9. (512 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (557 aa)
TRIM25E3 ubiquitin/ISG15 ligase TRIM25. (689 aa)
LOC112548964Uncharacterized protein LOC112548964. (433 aa)
PELI2E3 ubiquitin-protein ligase pellino homolog 2 isoform X1. (383 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (694 aa)
NFKBIENF-kappa-B inhibitor epsilon. (276 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7 isoform X1. (571 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (479 aa)
TAB3TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1. (698 aa)
LOC102374052Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1. (647 aa)
LOC102375854Optineurin-like. (117 aa)
TNIP1TNFAIP3-interacting protein 1. (524 aa)
TLR8Toll-like receptor 8 isoform X1; Belongs to the Toll-like receptor family. (1090 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein isoform X1. (219 aa)
RNF216E3 ubiquitin-protein ligase RNF216 isoform X1. (970 aa)
ZBP1Z-DNA-binding protein 1 isoform X1. (436 aa)
TMEM173Stimulator of interferon genes protein isoform X1. (469 aa)
TNFRSF25Tumor necrosis factor receptor superfamily member 25 isoform X1. (430 aa)
LOC102382314Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like. (785 aa)
ANKRD6Ankyrin repeat domain-containing protein 6 isoform X1. (815 aa)
TLR4LOW QUALITY PROTEIN: toll-like receptor 4; Belongs to the Toll-like receptor family. (849 aa)
TLR5Toll-like receptor 5 isoform X1; Belongs to the Toll-like receptor family. (870 aa)
SPATA2LSpermatogenesis-associated protein 2-like protein. (384 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (541 aa)
RBCK1ranBP-type and C3HC4-type zinc finger-containing protein 1. (852 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase 10. (205 aa)
IRAK1Interleukin-1 receptor-associated kinase 1 isoform X2. (543 aa)
TRAF4TNF receptor-associated factor. (465 aa)
LOC102368067Inhibitor of apoptosis protein-like. (633 aa)
LOC112551609Uncharacterized protein LOC112551609. (264 aa)
SHARPINLOW QUALITY PROTEIN: sharpin. (588 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (418 aa)
LOC112551715ranBP-type and C3HC4-type zinc finger-containing protein 1-like. (123 aa)
BCL10B-cell lymphoma/leukemia 10 isoform X1. (226 aa)
CLIP4CAP-Gly domain-containing linker protein 4 isoform X1. (748 aa)
UNC93B1Protein unc-93 homolog B1. (578 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (1022 aa)
NFKBIZNF-kappa-B inhibitor zeta isoform X1. (625 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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