(39 nodes) Mixed, incl. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, and TNFR1-induced proapoptotic signaling network (Alligator sinensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IRF3	Interferon regulatory factor 3 isoform X2. (432 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	IRF7	Interferon regulatory factor 7. (605 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (485 aa)
	CDC37	Hsp90 co-chaperone Cdc37 isoform X2. (376 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	IRAK2	Interleukin-1 receptor-associated kinase-like 2. (732 aa)
	IKBKG	NF-kappa-B essential modulator. (534 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20 isoform X3. (807 aa)
	LOC102376917	TNF receptor-associated factor 1-like. (328 aa)
	NOD1	Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (951 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog 1. (418 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2. (510 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (553 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (752 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4 isoform X1. (468 aa)
	LOC102374298	Receptor-interacting serine/threonine-protein kinase 2-like. (565 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (711 aa)
	IRAK3	Interleukin-1 receptor-associated kinase 3. (136 aa)
	TBK1	Serine/threonine-protein kinase TBK1 isoform X1. (741 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
	LOC112548281	TNF receptor-associated factor 6-like. (213 aa)
	RNF31	E3 ubiquitin-protein ligase RNF31. (930 aa)
	TAB2	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (557 aa)
	PELI2	E3 ubiquitin-protein ligase pellino homolog 2 isoform X1. (383 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (694 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7 isoform X1. (571 aa)
	TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1. (698 aa)
	ZBP1	Z-DNA-binding protein 1 isoform X1. (436 aa)
	TMEM173	Stimulator of interferon genes protein isoform X1. (469 aa)
	TNFRSF25	Tumor necrosis factor receptor superfamily member 25 isoform X1. (430 aa)
	TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (541 aa)
	RBCK1	ranBP-type and C3HC4-type zinc finger-containing protein 1. (852 aa)
	IRAK1	Interleukin-1 receptor-associated kinase 1 isoform X2. (543 aa)
	LOC102368067	Inhibitor of apoptosis protein-like. (633 aa)
	LOC112551609	Uncharacterized protein LOC112551609. (264 aa)
	SHARPIN	LOW QUALITY PROTEIN: sharpin. (588 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (418 aa)
	LOC112551715	ranBP-type and C3HC4-type zinc finger-containing protein 1-like. (123 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC37	PELI1	A0A1U7RP49	A0A1U7SP66	Hsp90 co-chaperone Cdc37 isoform X2.	E3 ubiquitin-protein ligase pellino homolog 1.	0.693
CDC37	PELI2	A0A1U7RP49	A0A3Q0G1N4	Hsp90 co-chaperone Cdc37 isoform X2.	E3 ubiquitin-protein ligase pellino homolog 2 isoform X1.	0.693
CDC37	TAB1	A0A1U7RP49	A0A3Q0H4V5	Hsp90 co-chaperone Cdc37 isoform X2.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1.	0.476
IKBKE	IKBKG	A0A1U8D6F4	A0A1U7S552	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	NF-kappa-B essential modulator.	0.922
IKBKE	IRF3	A0A1U8D6F4	A0A1U7R7U1	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Interferon regulatory factor 3 isoform X2.	0.987
IKBKE	IRF7	A0A1U8D6F4	A0A1U7RJL7	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Interferon regulatory factor 7.	0.967
IKBKE	LOC102368067	A0A1U8D6F4	A0A3Q0HET8	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Inhibitor of apoptosis protein-like.	0.579
IKBKE	LOC102376917	A0A1U8D6F4	A0A1U7SH81	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TNF receptor-associated factor 1-like.	0.600
IKBKE	LOC112548281	A0A1U8D6F4	A0A3Q0FPZ7	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TNF receptor-associated factor 6-like.	0.682
IKBKE	LOC112551609	A0A1U8D6F4	A0A3Q0HF59	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Uncharacterized protein LOC112551609.	0.807
IKBKE	PELI1	A0A1U8D6F4	A0A1U7SP66	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	E3 ubiquitin-protein ligase pellino homolog 1.	0.464
IKBKE	PELI2	A0A1U8D6F4	A0A3Q0G1N4	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	E3 ubiquitin-protein ligase pellino homolog 2 isoform X1.	0.415
IKBKE	RIPK1	A0A1U8D6F4	A0A1U8DC48	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.694
IKBKE	RNF31	A0A1U8D6F4	A0A3Q0FSD0	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	E3 ubiquitin-protein ligase RNF31.	0.827
IKBKE	TAB2	A0A1U8D6F4	A0A3Q0FUB8	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.	0.544
IKBKE	TAB3	A0A1U8D6F4	A0A3Q0G8M5	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1.	0.544
IKBKE	TANK	A0A1U8D6F4	A0A1U7RLR4	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TRAF family member-associated NF-kappa-B activator isoform X1.	0.992
IKBKE	TBK1	A0A1U8D6F4	A0A3Q0FHX9	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Serine/threonine-protein kinase TBK1 isoform X1.	0.901
IKBKE	TICAM1	A0A1U8D6F4	A0A3Q0G1N7	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.582
IKBKE	TMEM173	A0A1U8D6F4	A0A3Q0GQN5	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1.	Stimulator of interferon genes protein isoform X1.	0.992