STRINGSTRING
PSMC5 PSMC5 PSMA8 PSMA8 C1QTNF12 C1QTNF12 PSMB1 PSMB1 HTRA3 HTRA3 UBE2B UBE2B UBE2W UBE2W LOC102386226 LOC102386226 RPS27A RPS27A KCTD2 KCTD2 UBE2J2 UBE2J2 PSMB3 PSMB3 CEP112 CEP112 HACE1 HACE1 UCHL3 UCHL3 KATNB1 KATNB1 PSMA2 PSMA2 RNF8 RNF8 PSMD9 PSMD9 LOC102380489 LOC102380489 UBE2QL1 UBE2QL1 UBC UBC PSMA6 PSMA6 ADRM1 ADRM1 UBE3A UBE3A CDC34 CDC34 PSMA4 PSMA4 KATNBL1 KATNBL1 PSMD6 PSMD6 PSMA7 PSMA7 PSMD14 PSMD14 NUB1 NUB1 LOC102380731 LOC102380731 UBE2N UBE2N PSMG3 PSMG3 UBA6 UBA6 RANGAP1 RANGAP1 PSMG4 PSMG4 UCHL5 UCHL5 TRAF7 TRAF7 PSMD7 PSMD7 UBE2A UBE2A FAM192A FAM192A PSMC6 PSMC6 ATAD2B ATAD2B UBE2D1 UBE2D1 SENP1 SENP1 UBE2G2 UBE2G2 KATNA1 KATNA1 LOC102381860 LOC102381860 POMP POMP LOC102379476 LOC102379476 PSMC3 PSMC3 PSMB6 PSMB6 LOC102372038 LOC102372038 PSME2 PSME2 UBE2Q1 UBE2Q1 SATB2 SATB2 UBLCP1 UBLCP1 UBQLN4 UBQLN4 KATNAL2 KATNAL2 OTUB1 OTUB1 PSMD13 PSMD13 UBE2U UBE2U LOC102371352 LOC102371352 RNF168 RNF168 ARIH1 ARIH1 PSMC4 PSMC4 UBE2J1 UBE2J1 WAC WAC PSMA3 PSMA3 UBFD1 UBFD1 UBE2Q2 UBE2Q2 UBR2 UBR2 UBE2E3 UBE2E3 NGLY1 NGLY1 UBA52 UBA52 LOC102384381 LOC102384381 UBE2R2 UBE2R2 PIAS2 PIAS2 SENP7 SENP7 ZMIZ2 ZMIZ2 TRIP12 TRIP12 UBA1 UBA1 MIB2 MIB2 PSMC2 PSMC2 PSMD4 PSMD4 LOC106722823 LOC106722823 UBE2I UBE2I PSMB7 PSMB7 PIAS1 PIAS1 PSMB5 PSMB5 TOP1 TOP1 PSMD5 PSMD5 PSMB4 PSMB4 UCHL1 UCHL1 RNF40 RNF40 PSMD2 PSMD2 PSMD12 PSMD12 SUMO1 SUMO1 LOC102370521 LOC102370521 LOC102384916 LOC102384916 PSMA1 PSMA1 LOC106721866 LOC106721866 ZMIZ1 ZMIZ1 UBE3C UBE3C PIAS4 PIAS4 MPND MPND KIAA2012 KIAA2012 MARCH6 MARCH6 SUMO2 SUMO2 SENP6 SENP6 SENP2 SENP2 PSME3 PSME3 PSME4 PSME4 UBE2V2 UBE2V2 RNF20 RNF20 PSMD1 PSMD1 UBE2L3 UBE2L3 WFDC1 WFDC1 UBE2Z UBE2Z UBQLN1 UBQLN1 LOC102382728 LOC102382728 PSMD3 PSMD3 CSF3 CSF3 PSMG2 PSMG2 LOC102376114 LOC102376114 PSMG1 PSMG1 ZNF451 ZNF451 UBE2D2 UBE2D2 UBA7 UBA7 PSMB2 PSMB2 KATNAL1 KATNAL1 LOC102370479 LOC102370479 PSMD11 PSMD11 ECPAS ECPAS RNF169 RNF169 PSMC1 PSMC1 UBA2 UBA2 UBR5 UBR5 USP14 USP14 PAAF1 PAAF1 UBE2G1 UBE2G1 UBE2K UBE2K LOC112551423 LOC112551423 UBE2H UBE2H SAE1 SAE1 UBR1 UBR1 LOC102381672 LOC102381672 LOC102369421 LOC102369421 LOC102382249 LOC102382249 UBB UBB NFATC2IP NFATC2IP PIAS3 PIAS3 PSMD10 PSMD10 PSMA5 PSMA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMC526S proteasome regulatory subunit 8; Belongs to the AAA ATPase family. (411 aa)
PSMA8Proteasome subunit alpha type. (249 aa)
C1QTNF12Adipolin isoform X1. (320 aa)
PSMB1Proteasome subunit beta. (240 aa)
HTRA3Serine protease HTRA3 isoform X1. (466 aa)
UBE2BUbiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
UBE2WUbiquitin-conjugating enzyme E2 W isoform X1. (199 aa)
LOC102386226E3 ubiquitin-protein ligase Topors-like. (564 aa)
RPS27Aubiquitin-40S ribosomal protein S27a. (156 aa)
KCTD2BTB/POZ domain-containing protein KCTD2. (200 aa)
UBE2J2Ubiquitin-conjugating enzyme E2 J2. (259 aa)
PSMB3Proteasome subunit beta. (290 aa)
CEP112Centrosomal protein of 112 kDa isoform X1. (952 aa)
HACE1E3 ubiquitin-protein ligase HACE1 isoform X1. (910 aa)
UCHL3Ubiquitin carboxyl-terminal hydrolase. (194 aa)
KATNB1Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (657 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (474 aa)
PSMD926S proteasome non-ATPase regulatory subunit 9 isoform X1. (205 aa)
LOC102380489Ubiquitin-conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
UBE2QL1Ubiquitin-conjugating enzyme E2Q-like protein 1. (161 aa)
UBCpolyubiquitin-C. (381 aa)
PSMA6Proteasome endopeptidase complex; Belongs to the peptidase T1A family. (382 aa)
ADRM1Proteasomal ubiquitin receptor ADRM1. (298 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (879 aa)
CDC34Ubiquitin-conjugating enzyme E2 R1; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
KATNBL1KATNB1-like protein 1 isoform X1. (328 aa)
PSMD626S proteasome non-ATPase regulatory subunit 6. (317 aa)
PSMA7Proteasome subunit alpha type. (248 aa)
PSMD1426S proteasome non-ATPase regulatory subunit 14 isoform X1. (310 aa)
NUB1NEDD8 ultimate buster 1 isoform X1. (646 aa)
LOC102380731Ubiquitin-conjugating enzyme E2 E1 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
UBE2NUbiquitin-conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
PSMG3Proteasome assembly chaperone 3. (122 aa)
UBA6Ubiquitin-like modifier-activating enzyme 6. (1022 aa)
RANGAP1Ran GTPase-activating protein 1 isoform X1. (576 aa)
PSMG4Proteasome assembly chaperone 4 isoform X1. (126 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (331 aa)
TRAF7E3 ubiquitin-protein ligase TRAF7 isoform X1. (670 aa)
PSMD726S proteasome non-ATPase regulatory subunit 7. (297 aa)
UBE2AUbiquitin-conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
FAM192AProtein FAM192A isoform X1. (255 aa)
PSMC626S proteasome regulatory subunit 10B; Belongs to the AAA ATPase family. (373 aa)
ATAD2BATPase family AAA domain-containing protein 2B. (1406 aa)
UBE2D1Ubiquitin-conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (124 aa)
SENP1Sentrin-specific protease 1 isoform X1. (625 aa)
UBE2G2Ubiquitin-conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (165 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (491 aa)
LOC102381860Proteasome subunit beta. (277 aa)
POMPProteasome maturation protein. (141 aa)
LOC102379476Proteasome subunit beta type-9-like. (280 aa)
PSMC326S proteasome regulatory subunit 6A; Belongs to the AAA ATPase family. (422 aa)
PSMB6Proteasome subunit beta. (227 aa)
LOC102372038E3 SUMO-protein ligase PIAS2-like isoform X1. (371 aa)
PSME2Proteasome activator complex subunit 2. (242 aa)
UBE2Q1Ubiquitin-conjugating enzyme E2 Q1. (382 aa)
SATB2DNA-binding protein SATB. (740 aa)
UBLCP1Ubiquitin-like domain-containing CTD phosphatase 1. (318 aa)
UBQLN4Ubiquilin-4. (596 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (542 aa)
OTUB1Ubiquitin thioesterase OTUB1. (224 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13. (376 aa)
UBE2UUbiquitin-conjugating enzyme E2 U isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (326 aa)
LOC102371352Ubiquilin-1-like. (465 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (609 aa)
ARIH1RBR-type E3 ubiquitin transferase. (383 aa)
PSMC426S proteasome regulatory subunit 6B; Belongs to the AAA ATPase family. (402 aa)
UBE2J1Ubiquitin-conjugating enzyme E2 J1. (332 aa)
WACWW domain-containing adapter protein with coiled-coil isoform X1. (624 aa)
PSMA3Proteasome subunit alpha type. (260 aa)
UBFD1Ubiquitin domain-containing protein UBFD1. (186 aa)
UBE2Q2Ubiquitin-conjugating enzyme E2 Q2. (322 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1754 aa)
UBE2E3Ubiquitin-conjugating enzyme E2 E3 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (230 aa)
NGLY1peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase. (649 aa)
UBA52ubiquitin-60S ribosomal protein L40. (104 aa)
LOC102384381Ubiquitin-conjugating enzyme E2 L3-like; Belongs to the ubiquitin-conjugating enzyme family. (224 aa)
UBE2R2Ubiquitin-conjugating enzyme E2 R2 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
PIAS2LOW QUALITY PROTEIN: E3 SUMO-protein ligase PIAS2. (285 aa)
SENP7Sentrin-specific protease 7 isoform X1. (1053 aa)
ZMIZ2LOW QUALITY PROTEIN: zinc finger MIZ domain-containing protein 2. (906 aa)
TRIP12E3 ubiquitin-protein ligase TRIP12 isoform X1. (2067 aa)
UBA1Ubiquitin-like modifier-activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (1075 aa)
MIB2E3 ubiquitin-protein ligase MIB2 isoform X2. (954 aa)
PSMC226S proteasome regulatory subunit 7; Belongs to the AAA ATPase family. (428 aa)
PSMD426S proteasome non-ATPase regulatory subunit 4 isoform X1. (408 aa)
LOC106722823Proteasome subunit beta type-8-like isoform X1. (160 aa)
UBE2ISUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
PSMB7Proteasome subunit beta type-7. (211 aa)
PIAS1E3 SUMO-protein ligase PIAS1 isoform X1. (674 aa)
PSMB5Proteasome subunit beta. (249 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (751 aa)
PSMD526S proteasome non-ATPase regulatory subunit 5. (481 aa)
PSMB4LOW QUALITY PROTEIN: proteasome subunit beta type-4. (305 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (219 aa)
RNF40E3 ubiquitin protein ligase. (911 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (873 aa)
PSMD1226S proteasome non-ATPase regulatory subunit 12 isoform X2. (404 aa)
SUMO1Small ubiquitin-related modifier 1 isoform X1. (183 aa)
LOC102370521Interleukin-6 receptor subunit beta-like. (758 aa)
LOC102384916Dentin sialophosphoprotein. (834 aa)
PSMA1Proteasome endopeptidase complex. (265 aa)
LOC106721866Ubiquitin-conjugating enzyme E2 variant 1 isoform X1. (119 aa)
ZMIZ1Zinc finger MIZ domain-containing protein 1. (1066 aa)
UBE3CUbiquitin-protein ligase E3C. (1064 aa)
PIAS4E3 SUMO-protein ligase PIAS4 isoform X1. (531 aa)
MPNDMPN domain-containing protein. (468 aa)
KIAA2012LOW QUALITY PROTEIN: uncharacterized protein KIAA2012 homolog. (1359 aa)
MARCH6E3 ubiquitin-protein ligase MARCH6. (983 aa)
SUMO2Small ubiquitin-related modifier. (123 aa)
SENP6Sentrin-specific protease 6 isoform X1. (1157 aa)
SENP2Sentrin-specific protease 2 isoform X1. (621 aa)
PSME3Proteasome activator complex subunit 3. (193 aa)
PSME4Proteasome activator complex subunit 4 isoform X1. (1848 aa)
UBE2V2Ubiquitin-conjugating enzyme E2 variant 2 isoform X5. (199 aa)
RNF20E3 ubiquitin protein ligase. (1034 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
UBE2L3Ubiquitin-conjugating enzyme E2 L3 isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
WFDC1WAP four-disulfide core domain protein 1 isoform X1. (229 aa)
UBE2ZUbiquitin-conjugating enzyme E2 Z. (246 aa)
UBQLN1Ubiquilin-1. (534 aa)
LOC1023827282'-5'-oligoadenylate synthase 1-like. (518 aa)
PSMD326S proteasome non-ATPase regulatory subunit 3. (485 aa)
CSF3LOW QUALITY PROTEIN: granulocyte colony-stimulating factor. (235 aa)
PSMG2Proteasome assembly chaperone 2 isoform X1. (297 aa)
LOC102376114Protein SSUH2 homolog isoform X1. (403 aa)
PSMG1Proteasome assembly chaperone 1. (270 aa)
ZNF451E3 SUMO-protein ligase ZNF451 isoform X1. (1053 aa)
UBE2D2Ubiquitin-conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (221 aa)
UBA7Ubiquitin-like modifier-activating enzyme 7 isoform X1; Belongs to the ubiquitin-activating E1 family. (1027 aa)
PSMB2Proteasome subunit beta. (167 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily. (560 aa)
LOC102370479Signal transducer and activator of transcription 5B-like. (247 aa)
PSMD1126S proteasome non-ATPase regulatory subunit 11. (408 aa)
ECPASProteasome adapter and scaffold protein ECM29 isoform X1. (1839 aa)
RNF169E3 ubiquitin-protein ligase RNF169 isoform X1. (559 aa)
PSMC126S proteasome regulatory subunit 4; Belongs to the AAA ATPase family. (367 aa)
UBA2SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (543 aa)
UBR5E3 ubiquitin-protein ligase UBR5. (2815 aa)
USP14Ubiquitin carboxyl-terminal hydrolase. (555 aa)
PAAF1Proteasomal ATPase-associated factor 1 isoform X1. (430 aa)
UBE2G1Ubiquitin-conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (188 aa)
UBE2KUbiquitin-conjugating enzyme E2 K isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (197 aa)
LOC112551423Sentrin-specific protease 2-like. (495 aa)
UBE2HUbiquitin-conjugating enzyme E2 H; Belongs to the ubiquitin-conjugating enzyme family. (113 aa)
SAE1SUMO-activating enzyme subunit 1. (242 aa)
UBR1E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1753 aa)
LOC102381672Uncharacterized protein LOC102381672. (494 aa)
LOC102369421Granulocyte colony-stimulating factor receptor. (1001 aa)
LOC102382249Small ubiquitin-related modifier 3. (136 aa)
UBBpolyubiquitin-B. (233 aa)
NFATC2IPNFATC2-interacting protein. (423 aa)
PIAS3E3 SUMO-protein ligase PIAS3 isoform X1. (685 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10. (157 aa)
PSMA5Proteasome endopeptidase complex. (183 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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