23 items (Alligator sinensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC102372585	Transcription factor GATA-6. (226 aa)
	GATA2	Endothelial transcription factor GATA-2. (309 aa)
	ZBTB49	Zinc finger and BTB domain-containing protein 49 isoform X1. (777 aa)
	ZBTB17	LOW QUALITY PROTEIN: zinc finger and BTB domain-containing protein 17. (814 aa)
	TRERF1	Transcriptional-regulating factor 1 isoform X1. (1178 aa)
	VGLL4	Transcription cofactor vestigial-like protein 4 isoform X1. (295 aa)
	LOC102381382	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1565 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (442 aa)
	EP300	Histone acetyltransferase p300 isoform X1. (2149 aa)
	CREBBP	CREB-binding protein. (2468 aa)
	MED25	Mediator of RNA polymerase II transcription subunit 25. (825 aa)
	CCNT2	LOW QUALITY PROTEIN: cyclin-T2. (661 aa)
	AR	Androgen receptor isoform X2. (430 aa)
	EPAS1	Endothelial PAS domain-containing protein 1 isoform X1. (814 aa)
	ESR1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1051 aa)
	MED6	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (248 aa)
	CIT	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2081 aa)
	LOC102373921	Mothers against decapentaplegic homolog. (405 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (385 aa)
	GATA1	LOW QUALITY PROTEIN: erythroid transcription factor. (323 aa)
	SMAD4	Mothers against decapentaplegic homolog. (554 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CREBBP	A0A3Q0G8Z2	A0A1U8DJG6	Androgen receptor isoform X2.	CREB-binding protein.	0.756
AR	EP300	A0A3Q0G8Z2	A0A1U8D7N2	Androgen receptor isoform X2.	Histone acetyltransferase p300 isoform X1.	0.730
AR	ESR1	A0A3Q0G8Z2	A0A3Q0GNM7	Androgen receptor isoform X2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.701
AR	LOC102381382	A0A3Q0G8Z2	A0A1U8D0V4	Androgen receptor isoform X2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.517
AR	MED1	A0A3Q0G8Z2	A0A1U8D3S0	Androgen receptor isoform X2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.517
CREBBP	AR	A0A1U8DJG6	A0A3Q0G8Z2	CREB-binding protein.	Androgen receptor isoform X2.	0.756
CREBBP	EP300	A0A1U8DJG6	A0A1U8D7N2	CREB-binding protein.	Histone acetyltransferase p300 isoform X1.	0.998
CREBBP	EPAS1	A0A1U8DJG6	A0A3Q0GKQ4	CREB-binding protein.	Endothelial PAS domain-containing protein 1 isoform X1.	0.903
CREBBP	ESR1	A0A1U8DJG6	A0A3Q0GNM7	CREB-binding protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.911
CREBBP	GATA1	A0A1U8DJG6	A0A3Q0HBT6	CREB-binding protein.	LOW QUALITY PROTEIN: erythroid transcription factor.	0.647
CREBBP	GATA2	A0A1U8DJG6	A0A1U7RD86	CREB-binding protein.	Endothelial transcription factor GATA-2.	0.651
CREBBP	GATA3	A0A1U8DJG6	A0A3Q0HAJ7	CREB-binding protein.	Trans-acting T-cell-specific transcription factor GATA-3.	0.703
CREBBP	LOC102372585	A0A1U8DJG6	A0A3Q0HH24	CREB-binding protein.	Transcription factor GATA-6.	0.512
CREBBP	LOC102373921	A0A1U8DJG6	A0A3Q0H8N6	CREB-binding protein.	Mothers against decapentaplegic homolog.	0.639
CREBBP	LOC102381382	A0A1U8DJG6	A0A1U8D0V4	CREB-binding protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.705
CREBBP	MED1	A0A1U8DJG6	A0A1U8D3S0	CREB-binding protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.705
CREBBP	SMAD4	A0A1U8DJG6	A0A3Q0HG95	CREB-binding protein.	Mothers against decapentaplegic homolog.	0.639
EP300	AR	A0A1U8D7N2	A0A3Q0G8Z2	Histone acetyltransferase p300 isoform X1.	Androgen receptor isoform X2.	0.730
EP300	CREBBP	A0A1U8D7N2	A0A1U8DJG6	Histone acetyltransferase p300 isoform X1.	CREB-binding protein.	0.998
EP300	EPAS1	A0A1U8D7N2	A0A3Q0GKQ4	Histone acetyltransferase p300 isoform X1.	Endothelial PAS domain-containing protein 1 isoform X1.	0.900