STRINGSTRING
SFRP2 SFRP2 MTMR4 MTMR4 SMAD6 SMAD6 HEXA HEXA SMAD4 SMAD4 LOC102368464 LOC102368464 LEF1 LEF1 APPL1 APPL1 PTPRK PTPRK LOC102373921 LOC102373921 ACVRL1 ACVRL1 SMAD7 SMAD7 GDF15 GDF15 TAB1 TAB1 MAGI2 MAGI2 INHBB INHBB AKAP3 AKAP3 LOC112550796 LOC112550796 DLX5 DLX5 STAT3 STAT3 BMP6 BMP6 CITED1 CITED1 HIVEP1 HIVEP1 FLCN FLCN CAV2 CAV2 CHST11 CHST11 NODAL NODAL FAM83G FAM83G TWSG1 TWSG1 BMP3 BMP3 HPGD HPGD LRRC32 LRRC32 BMPER BMPER TGFB3 TGFB3 ACVR1C ACVR1C ZYX ZYX WFIKKN2 WFIKKN2 ACVR2B ACVR2B ACVR1 ACVR1 LOC102372873 LOC102372873 PXN PXN TGFBR1 TGFBR1 LOC102388833 LOC102388833 LOC102386323 LOC102386323 DDX5 DDX5 JADE2 JADE2 LOC112548515 LOC112548515 CHRD CHRD LOC112548514 LOC112548514 TP53 TP53 LOC102385404 LOC102385404 SPART SPART LOC112548135 LOC112548135 SMAD2 SMAD2 NRROS NRROS LOC102376243 LOC102376243 RGMB RGMB TGFB1I1 TGFB1I1 GDF11 GDF11 SMAD9 SMAD9 CLDN5 CLDN5 GLG1 GLG1 JUN JUN LOC102387993 LOC102387993 BMPR2 BMPR2 BAMBI BAMBI LOC102371879 LOC102371879 LOC102385749 LOC102385749 ITGB8 ITGB8 AMH AMH TGFB1 TGFB1 BMPR1B BMPR1B ISM2 ISM2 GDF5 GDF5 HJV HJV BMP5 BMP5 NUP93 NUP93 SKIL SKIL LOC102374786 LOC102374786 INHA INHA WNT1 WNT1 BMP10 BMP10 MSTN MSTN ACVR1B ACVR1B AMHR2 AMHR2 FKBP8 FKBP8 ENG ENG LPXN LPXN SMAD3 SMAD3 ACVR2A ACVR2A BMP4 BMP4 LOC102378152 LOC102378152 TGFBR2 TGFBR2 CCDC142 CCDC142 BMPR1A BMPR1A APPL2 APPL2 ZNF831 ZNF831 GDF7 GDF7 BMP7 BMP7 RNF111 RNF111 FOXF1 FOXF1 LOC102378535 LOC102378535 FUT8 FUT8 LOC102380095 LOC102380095 RGMA RGMA NCEH1 NCEH1 SIRT1 SIRT1 TMEM100 TMEM100 LOC102387083 LOC102387083 SMPD3 SMPD3 SMURF1 SMURF1 GDF1 GDF1 DLX3 DLX3 SOSTDC1 SOSTDC1 TGFBR3 TGFBR3 INHBA INHBA PPM1L PPM1L SLC33A1 SLC33A1 CDH5 CDH5 GDF10 GDF10 BMP15 BMP15 NLK NLK USP9X USP9X FOS FOS SOST SOST SMAD1 SMAD1 PML PML ITGB5 ITGB5 SMAD5 SMAD5 PDCD4 PDCD4 TGFB2 TGFB2 SKI SKI SMURF2 SMURF2 FST FST GDF2 GDF2 ITGB6 ITGB6 LOC102381539 LOC102381539 LOC102368332 LOC102368332 BMP2 BMP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SFRP2Secreted frizzled-related protein 2. (294 aa)
MTMR4Myotubularin-related protein 4 isoform X3. (1171 aa)
SMAD6Mothers against decapentaplegic homolog 6. (251 aa)
HEXABeta-hexosaminidase subunit alpha. (336 aa)
SMAD4Mothers against decapentaplegic homolog. (554 aa)
LOC102368464LOW QUALITY PROTEIN: uncharacterized protein LOC102368464. (355 aa)
LEF1Lymphoid enhancer-binding factor 1. (349 aa)
APPL1DCC-interacting protein 13-alpha isoform X1. (669 aa)
PTPRKReceptor-type tyrosine-protein phosphatase kappa. (1490 aa)
LOC102373921Mothers against decapentaplegic homolog. (405 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
SMAD7Mothers against decapentaplegic homolog. (284 aa)
GDF15Growth/differentiation factor 15. (355 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (541 aa)
MAGI2Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2. (1291 aa)
INHBBInhibin beta B chain. (319 aa)
AKAP3A-kinase anchor protein 3. (825 aa)
LOC112550796Sperm acrosome membrane-associated protein 4-like. (127 aa)
DLX5Homeobox protein DLX-5. (143 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
BMP6Bone morphogenetic protein 6 isoform X1. (320 aa)
CITED1Cbp/p300-interacting transactivator 1. (220 aa)
HIVEP1Zinc finger protein 40 isoform X1. (2723 aa)
FLCNFolliculin. (576 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
CHST11Carbohydrate sulfotransferase. (320 aa)
NODALNodal homolog. (307 aa)
FAM83GProtein FAM83G. (892 aa)
TWSG1Twisted gastrulation protein homolog 1 isoform X1. (247 aa)
BMP3Bone morphogenetic protein 3 isoform X1. (331 aa)
HPGD15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (252 aa)
LRRC32Leucine-rich repeat-containing protein 32 isoform X1. (704 aa)
BMPERBMP-binding endothelial regulator protein isoform X1. (649 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (342 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (445 aa)
ZYXZyxin isoform X1. (598 aa)
WFIKKN2WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2. (480 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (553 aa)
LOC102372873Protein PML-like isoform X1. (652 aa)
PXNPaxillin. (1302 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (440 aa)
LOC102388833A-kinase anchor protein 4-like. (792 aa)
LOC102386323Cryptic protein-like. (195 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (611 aa)
JADE2E3 ubiquitin-protein ligase Jade-2 isoform X1. (888 aa)
LOC112548515A-kinase anchor protein 4-like. (305 aa)
CHRDChordin isoform X1. (788 aa)
LOC112548514A-kinase anchor protein 4-like. (826 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (397 aa)
LOC102385404A-kinase anchor protein 4-like isoform X1. (794 aa)
SPARTSpartin isoform X1. (636 aa)
LOC112548135Inhibin beta C chain-like. (364 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
NRROSNegative regulator of reactive oxygen species isoform X1. (690 aa)
LOC102376243Programmed cell death protein 4. (319 aa)
RGMBRGM domain family member B. (322 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Belongs to the paxillin family. (449 aa)
GDF11Growth/differentiation factor 11. (342 aa)
SMAD9Mothers against decapentaplegic homolog. (475 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (177 aa)
GLG1Golgi apparatus protein 1. (1079 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (282 aa)
LOC102387993Repulsive guidance molecule A-like isoform X1. (411 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (218 aa)
LOC102371879TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
LOC102385749Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (478 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (709 aa)
AMHMuellerian-inhibiting factor. (677 aa)
TGFB1Transforming growth factor beta-1. (235 aa)
BMPR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (582 aa)
ISM2Isthmin-2. (551 aa)
GDF5Growth/differentiation factor 5. (500 aa)
HJVHemojuvelin isoform X1. (403 aa)
BMP5Bone morphogenetic protein 5. (453 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
SKILSki-like protein. (689 aa)
LOC102374786Lymphocyte antigen 6G6e-like. (124 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (326 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
BMP10Bone morphogenetic protein 10. (426 aa)
MSTNLOW QUALITY PROTEIN: growth/differentiation factor 8. (375 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (545 aa)
FKBP8Peptidylprolyl isomerase. (416 aa)
ENGEndoglin. (667 aa)
LPXNLeupaxin. (388 aa)
SMAD3Mothers against decapentaplegic homolog. (321 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
BMP4Bone morphogenetic protein 4. (341 aa)
LOC102378152Bone morphogenetic protein 2-like. (474 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
CCDC142Coiled-coil domain-containing protein 142. (583 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
APPL2DCC-interacting protein 13-beta isoform X1. (659 aa)
ZNF831LOW QUALITY PROTEIN: zinc finger protein 831. (1861 aa)
GDF7Growth/differentiation factor 7. (216 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X2. (1014 aa)
FOXF1Forkhead box protein F1. (340 aa)
LOC102378535Protein PML-like isoform X1. (852 aa)
FUT8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family. (576 aa)
LOC102380095Bone morphogenetic protein 2-like. (386 aa)
RGMARepulsive guidance molecule A. (450 aa)
NCEH1Neutral cholesterol ester hydrolase 1 isoform X1. (408 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
TMEM100Transmembrane protein 100. (134 aa)
LOC102387083Bone morphogenetic protein 8A. (298 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (665 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (718 aa)
GDF1Embryonic growth/differentiation factor 1. (373 aa)
DLX3Homeobox protein DLX-3. (287 aa)
SOSTDC1Sclerostin domain-containing protein 1. (204 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (885 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (424 aa)
PPM1LProtein phosphatase 1L isoform X1. (360 aa)
SLC33A1Acetyl-coenzyme A transporter 1. (487 aa)
CDH5Cadherin-5 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (778 aa)
GDF10Growth/differentiation factor 10. (387 aa)
BMP15Bone morphogenetic protein 15. (392 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (525 aa)
USP9XProbable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family. (2552 aa)
FOSProto-oncogene c-Fos. (335 aa)
SOSTLOW QUALITY PROTEIN: sclerostin. (210 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
PMLProtein PML. (586 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (690 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
PDCD4Programmed cell death protein 4. (468 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
SKISki oncogene isoform X1. (715 aa)
SMURF2E3 ubiquitin-protein ligase. (748 aa)
FSTFollistatin isoform X1. (343 aa)
GDF2Growth/differentiation factor 2. (430 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (789 aa)
LOC102381539Cryptic protein-like isoform X1. (185 aa)
LOC102368332Left-right determination factor. (362 aa)
BMP2Bone morphogenetic protein 2. (297 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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