STRINGSTRING
EPHA2 EPHA2 MED1 MED1 PLS1 PLS1 LATS1 LATS1 LOC102380036 LOC102380036 AGPAT2 AGPAT2 OVOL2 OVOL2 LOC106722579 LOC106722579 EDAR EDAR NSDHL NSDHL FOSL2 FOSL2 WDPCP WDPCP GLI1 GLI1 WNT16 WNT16 SLC44A4 SLC44A4 LOC102381512 LOC102381512 IFT172 IFT172 OVOL1 OVOL1 NOM1 NOM1 PIAS4 PIAS4 KAZN KAZN CLIC4 CLIC4 POU2F3 POU2F3 EDA EDA LGR4 LGR4 LOC102368598 LOC102368598 SLC4A7 SLC4A7 PDZD7 PDZD7 TP63 TP63 GRHL1 GRHL1 KCNQ1 KCNQ1 PLA2G10 PLA2G10 BCL11B BCL11B S1PR2 S1PR2 SOS1 SOS1 USH1C USH1C LOC112550422 LOC112550422 SPINT1 SPINT1 LOC102378300 LOC102378300 PTCH2 PTCH2 LGR5 LGR5 UGCG UGCG USH2A USH2A GSDME GSDME LOC102384210 LOC102384210 SVEP1 SVEP1 GRXCR2 GRXCR2 LOC102376634 LOC102376634 NF1 NF1 LOC102377836 LOC102377836 OPN3 OPN3 EXPH5 EXPH5 LOC102368725 LOC102368725 LOC102385059 LOC102385059 SCRIB SCRIB ERCC2 ERCC2 LOC102379545 LOC102379545 LOC102380041 LOC102380041 ST14 ST14 LOC102372585 LOC102372585 OVOL3 OVOL3 ZMPSTE24 ZMPSTE24 LOC102373427 LOC102373427 LOC102381382 LOC102381382 EVPL EVPL MADCAM1 MADCAM1 LOC102388574 LOC102388574 TRPC4AP TRPC4AP LOC102375921 LOC102375921 TMEM79 TMEM79 PPP1R18 PPP1R18 PPARA PPARA ZDHHC21 ZDHHC21 TXNIP TXNIP LOC102372247 LOC102372247 FOXN1 FOXN1 LOC102388130 LOC102388130 LOC102377597 LOC102377597 LOC102371761 LOC102371761 JAG1 JAG1 ACVR1B ACVR1B LOC102379785 LOC102379785 KRT8 KRT8 GRXCR1 GRXCR1 YBX1 YBX1 FZD3 FZD3 REST REST LOC102388048 LOC102388048 CLRN1 CLRN1 JAG2 JAG2 LOC102378082 LOC102378082 LOC102372665 LOC102372665 CTNNB1 CTNNB1 SMO SMO LOC102373665 LOC102373665 LOC102371330 LOC102371330 TMEM132E TMEM132E GRHL2 GRHL2 SEC24B SEC24B WHRN WHRN TPRN TPRN SLITRK6 SLITRK6 KRT80 KRT80 TSHZ1 TSHZ1 PAX6 PAX6 IFT74 IFT74 MYO6 MYO6 HOXC13 HOXC13 ANXA1 ANXA1 ZNF750 ZNF750 IGFBP5 IGFBP5 ERCC3 ERCC3 DLX3 DLX3 ACER1 ACER1 SOSTDC1 SOSTDC1 TFDP1 TFDP1 DLL1 DLL1 INHBA INHBA FA2H FA2H INTU INTU ASAH1 ASAH1 KDF1 KDF1 LRRC1 LRRC1 PTCH1 PTCH1 SAV1 SAV1 TGFB2 TGFB2 FST FST PPL PPL LATS2 LATS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPHA2Ephrin type-A receptor 2. (1000 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1565 aa)
PLS1Plastin-1. (628 aa)
LATS1Serine/threonine-protein kinase LATS1 isoform X1. (1138 aa)
LOC102380036Keratin, type II cytoskeletal 5-like; Belongs to the intermediate filament family. (663 aa)
AGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (235 aa)
OVOL2Transcription factor Ovo-like 2. (262 aa)
LOC106722579Keratin, type II cytoskeletal 4-like; Belongs to the intermediate filament family. (570 aa)
EDARTumor necrosis factor receptor superfamily member EDAR. (448 aa)
NSDHLSterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Belongs to the 3-beta-HSD family. (345 aa)
FOSL2Fos-related antigen 2 isoform X1. (351 aa)
WDPCPWD repeat-containing and planar cell polarity effector protein fritz homolog isoform X1. (712 aa)
GLI1Zinc finger protein GLI1. (747 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (257 aa)
SLC44A4LOW QUALITY PROTEIN: choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (777 aa)
LOC102381512Usherin-like. (357 aa)
IFT172Intraflagellar transport protein 172 homolog. (1775 aa)
OVOL1Putative transcription factor Ovo-like 1. (249 aa)
NOM1Nucleolar MIF4G domain-containing protein 1. (533 aa)
PIAS4E3 SUMO-protein ligase PIAS4 isoform X1. (531 aa)
KAZNKazrin isoform X2. (632 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (255 aa)
POU2F3POU domain protein. (440 aa)
EDAectodysplasin-A; Belongs to the tumor necrosis factor family. (236 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (887 aa)
LOC102368598Phospholipase A(2). (226 aa)
SLC4A7Anion exchange protein. (1246 aa)
PDZD7PDZ domain-containing protein 7. (855 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
GRHL1LOW QUALITY PROTEIN: grainyhead-like protein 1 homolog. (636 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1 isoform X1; Belongs to the potassium channel family. (582 aa)
PLA2G10Phospholipase A(2). (182 aa)
BCL11BLOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B. (886 aa)
S1PR2Sphingosine 1-phosphate receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (406 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1288 aa)
USH1CHarmonin. (880 aa)
LOC112550422Uncharacterized protein LOC112550422. (263 aa)
SPINT1Kunitz-type protease inhibitor 1. (448 aa)
LOC102378300Tumor necrosis factor receptor superfamily member 16-like. (384 aa)
PTCH2Protein patched homolog 2. (866 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (883 aa)
UGCGCeramide glucosyltransferase isoform X1. (370 aa)
USH2AUsherin. (4693 aa)
GSDMEgasdermin-E isoform X1. (500 aa)
LOC102384210Potassium voltage-gated channel subfamily KQT member 1-like isoform X1; Belongs to the potassium channel family. (652 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1. (3582 aa)
GRXCR2Glutaredoxin domain-containing cysteine-rich protein 2 isoform X1. (278 aa)
LOC102376634Uncharacterized protein LOC102376634. (787 aa)
NF1Neurofibromin. (2861 aa)
LOC102377836Keratin, type II cytoskeletal cochleal-like; Belongs to the intermediate filament family. (548 aa)
OPN3Opsin-3; Belongs to the G-protein coupled receptor 1 family. (338 aa)
EXPH5Exophilin-5 isoform X1. (1984 aa)
LOC102368725Ovoinhibitor-like. (552 aa)
LOC102385059Suppressor of tumorigenicity 14 protein-like. (817 aa)
SCRIBProtein scribble homolog. (1923 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD. (701 aa)
LOC102379545Keratin, type II cytoskeletal 3-like; Belongs to the intermediate filament family. (653 aa)
LOC102380041Keratin, type II cytoskeletal 6C-like; Belongs to the intermediate filament family. (650 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. (842 aa)
LOC102372585Transcription factor GATA-6. (226 aa)
OVOL3Putative transcription factor ovo-like protein 3. (274 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (460 aa)
LOC102373427LOW QUALITY PROTEIN: cornifelin homolog. (104 aa)
LOC102381382Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
EVPLEnvoplakin isoform X1. (2025 aa)
MADCAM1Mucosal addressin cell adhesion molecule 1. (506 aa)
LOC102388574Transmembrane O-methyltransferase homolog. (259 aa)
TRPC4APShort transient receptor potential channel 4-associated protein. (452 aa)
LOC102375921Short transient receptor potential channel 4-associated protein-like. (271 aa)
TMEM79Transmembrane protein 79. (393 aa)
PPP1R18LOW QUALITY PROTEIN: phostensin. (743 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
TXNIPThioredoxin-interacting protein. (391 aa)
LOC102372247LOW QUALITY PROTEIN: uncharacterized protein LOC102372247; Belongs to the intermediate filament family. (1222 aa)
FOXN1Forkhead box protein N1 isoform X1. (646 aa)
LOC102388130Serine protease inhibitor Kazal-type 5. (338 aa)
LOC102377597Keratin, type II cytoskeletal cochleal; Belongs to the intermediate filament family. (525 aa)
LOC102371761Keratin, type II cytoskeletal 6A; Belongs to the intermediate filament family. (519 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (453 aa)
LOC102379785Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (452 aa)
KRT8Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (480 aa)
GRXCR1Glutaredoxin domain-containing cysteine-rich protein 1. (294 aa)
YBX1LOW QUALITY PROTEIN: nuclease-sensitive element-binding protein 1. (282 aa)
FZD3LOW QUALITY PROTEIN: frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (670 aa)
RESTRE1-silencing transcription factor. (894 aa)
LOC102388048Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (511 aa)
CLRN1Clarin-1. (232 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1228 aa)
LOC102378082Keratin, type II cytoskeletal 5-like; Belongs to the intermediate filament family. (672 aa)
LOC102372665Keratin, type II cytoskeletal 6A; Belongs to the intermediate filament family. (633 aa)
CTNNB1Catenin beta-1. (784 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (803 aa)
LOC102373665Keratin, type II cytoskeletal 1-like; Belongs to the intermediate filament family. (474 aa)
LOC102371330Keratin, type II cytoskeletal cochleal-like; Belongs to the intermediate filament family. (502 aa)
TMEM132ETransmembrane protein 132E isoform X1. (1061 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X1. (636 aa)
SEC24BProtein transport protein Sec24B. (1193 aa)
WHRNWhirlin. (817 aa)
TPRNTaperin. (420 aa)
SLITRK6LOW QUALITY PROTEIN: SLIT and NTRK-like protein 6. (851 aa)
KRT80Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (570 aa)
TSHZ1Teashirt homolog 1 isoform X1. (1072 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
IFT74Intraflagellar transport protein 74 homolog isoform X1. (598 aa)
MYO6Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
HOXC13Homeobox protein Hox-C13. (307 aa)
ANXA1Annexin. (342 aa)
ZNF750Zinc finger protein 750. (703 aa)
IGFBP5Insulin-like growth factor-binding protein 5. (238 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB. (779 aa)
DLX3Homeobox protein DLX-3. (287 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
SOSTDC1Sclerostin domain-containing protein 1. (204 aa)
TFDP1Transcription factor. (412 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (424 aa)
FA2HFatty acid 2-hydroxylase; Belongs to the sterol desaturase family. (301 aa)
INTUProtein inturned isoform X1. (912 aa)
ASAH1Acid ceramidase; Belongs to the acid ceramidase family. (393 aa)
KDF1Keratinocyte differentiation factor 1. (418 aa)
LRRC1Leucine-rich repeat-containing protein 1. (443 aa)
PTCH1Protein patched homolog 1 isoform X1. (1326 aa)
SAV1Protein salvador homolog 1. (351 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
FSTFollistatin isoform X1. (343 aa)
PPLPeriplakin. (1763 aa)
LATS2Non-specific serine/threonine protein kinase. (1127 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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