89 items (Alligator sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	LOC102378082	Keratin, type II cytoskeletal 5-like; Belongs to the intermediate filament family. (672 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1228 aa)
	CLRN1	Clarin-1. (232 aa)
	LOC102388048	Cytochrome P450 26B1; Belongs to the cytochrome P450 family. (511 aa)
	REST	RE1-silencing transcription factor. (894 aa)
	GRXCR1	Glutaredoxin domain-containing cysteine-rich protein 1. (294 aa)
	KRT8	Keratin, type II cytoskeletal 8; Belongs to the intermediate filament family. (480 aa)
	LOC102379785	Keratin, type II cytoskeletal 8-like; Belongs to the intermediate filament family. (452 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
	LOC102371761	Keratin, type II cytoskeletal 6A; Belongs to the intermediate filament family. (519 aa)
	LOC102377597	Keratin, type II cytoskeletal cochleal; Belongs to the intermediate filament family. (525 aa)
	LOC102388130	Serine protease inhibitor Kazal-type 5. (338 aa)
	FOXN1	Forkhead box protein N1 isoform X1. (646 aa)
	LOC102372247	LOW QUALITY PROTEIN: uncharacterized protein LOC102372247; Belongs to the intermediate filament family. (1222 aa)
	TXNIP	Thioredoxin-interacting protein. (391 aa)
	PPP1R18	LOW QUALITY PROTEIN: phostensin. (743 aa)
	TMEM79	Transmembrane protein 79. (393 aa)
	LOC102388574	Transmembrane O-methyltransferase homolog. (259 aa)
	MADCAM1	Mucosal addressin cell adhesion molecule 1. (506 aa)
	LOC102381382	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
	EPHA2	Ephrin type-A receptor 2. (1000 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1565 aa)
	PLS1	Plastin-1. (628 aa)
	LATS1	Serine/threonine-protein kinase LATS1 isoform X1. (1138 aa)
	LOC102380036	Keratin, type II cytoskeletal 5-like; Belongs to the intermediate filament family. (663 aa)
	OVOL2	Transcription factor Ovo-like 2. (262 aa)
	LOC106722579	Keratin, type II cytoskeletal 4-like; Belongs to the intermediate filament family. (570 aa)
	FOSL2	Fos-related antigen 2 isoform X1. (351 aa)
	WDPCP	WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X1. (712 aa)
	GLI1	Zinc finger protein GLI1. (747 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (257 aa)
	SLC44A4	LOW QUALITY PROTEIN: choline transporter-like protein 4; Belongs to the CTL (choline transporter-like) family. (777 aa)
	LOC102381512	Usherin-like. (357 aa)
	OVOL1	Putative transcription factor Ovo-like 1. (249 aa)
	KAZN	Kazrin isoform X2. (632 aa)
	CLIC4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (255 aa)
	SLC4A7	Anion exchange protein. (1246 aa)
	PDZD7	PDZ domain-containing protein 7. (855 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	KCNQ1	Potassium voltage-gated channel subfamily KQT member 1 isoform X1; Belongs to the potassium channel family. (582 aa)
	BCL11B	LOW QUALITY PROTEIN: B-cell lymphoma/leukemia 11B. (886 aa)
	S1PR2	Sphingosine 1-phosphate receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (406 aa)
	USH1C	Harmonin. (880 aa)
	LOC112550422	Uncharacterized protein LOC112550422. (263 aa)
	PTCH2	Protein patched homolog 2. (866 aa)
	UGCG	Ceramide glucosyltransferase isoform X1. (370 aa)
	USH2A	Usherin. (4693 aa)
	GSDME	gasdermin-E isoform X1. (500 aa)
	LOC102384210	Potassium voltage-gated channel subfamily KQT member 1-like isoform X1; Belongs to the potassium channel family. (652 aa)
	GRXCR2	Glutaredoxin domain-containing cysteine-rich protein 2 isoform X1. (278 aa)
	LOC102376634	Uncharacterized protein LOC102376634. (787 aa)
	LOC102377836	Keratin, type II cytoskeletal cochleal-like; Belongs to the intermediate filament family. (548 aa)
	OPN3	Opsin-3; Belongs to the G-protein coupled receptor 1 family. (338 aa)
	EXPH5	Exophilin-5 isoform X1. (1984 aa)
	LOC102368725	Ovoinhibitor-like. (552 aa)
	LOC102385059	Suppressor of tumorigenicity 14 protein-like. (817 aa)
	SCRIB	Protein scribble homolog. (1923 aa)
	ERCC2	General transcription and DNA repair factor IIH helicase subunit XPD. (701 aa)
	LOC102379545	Keratin, type II cytoskeletal 3-like; Belongs to the intermediate filament family. (653 aa)
	LOC102380041	Keratin, type II cytoskeletal 6C-like; Belongs to the intermediate filament family. (650 aa)
	ST14	Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. (842 aa)
	LOC102372585	Transcription factor GATA-6. (226 aa)
	OVOL3	Putative transcription factor ovo-like protein 3. (274 aa)
	LOC102373427	LOW QUALITY PROTEIN: cornifelin homolog. (104 aa)
	LOC102372665	Keratin, type II cytoskeletal 6A; Belongs to the intermediate filament family. (633 aa)
	LOC102373665	Keratin, type II cytoskeletal 1-like; Belongs to the intermediate filament family. (474 aa)
	LOC102371330	Keratin, type II cytoskeletal cochleal-like; Belongs to the intermediate filament family. (502 aa)
	TMEM132E	Transmembrane protein 132E isoform X1. (1061 aa)
	SEC24B	Protein transport protein Sec24B. (1193 aa)
	WHRN	Whirlin. (817 aa)
	TPRN	Taperin. (420 aa)
	SLITRK6	LOW QUALITY PROTEIN: SLIT and NTRK-like protein 6. (851 aa)
	KRT80	Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family. (570 aa)
	PAX6	Paired box protein Pax-6 isoform X1. (436 aa)
	IFT74	Intraflagellar transport protein 74 homolog isoform X1. (598 aa)
	MYO6	Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
	ANXA1	Annexin. (342 aa)
	ERCC3	General transcription and DNA repair factor IIH helicase subunit XPB. (779 aa)
	DLX3	Homeobox protein DLX-3. (287 aa)
	ACER1	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
	FA2H	Fatty acid 2-hydroxylase; Belongs to the sterol desaturase family. (301 aa)
	INTU	Protein inturned isoform X1. (912 aa)
	ASAH1	Acid ceramidase; Belongs to the acid ceramidase family. (393 aa)
	KDF1	Keratinocyte differentiation factor 1. (418 aa)
	LRRC1	Leucine-rich repeat-containing protein 1. (443 aa)
	PTCH1	Protein patched homolog 1 isoform X1. (1326 aa)
	SAV1	Protein salvador homolog 1. (351 aa)
	LATS2	Non-specific serine/threonine protein kinase. (1127 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACER1	ASAH1	A0A1U7RRD1	A0A1U7RKC2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Acid ceramidase; Belongs to the acid ceramidase family.	0.952
ACER1	UGCG	A0A1U7RRD1	A0A3Q0GYE9	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	Ceramide glucosyltransferase isoform X1.	0.936
ASAH1	ACER1	A0A1U7RKC2	A0A1U7RRD1	Acid ceramidase; Belongs to the acid ceramidase family.	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.	0.952
ASAH1	UGCG	A0A1U7RKC2	A0A3Q0GYE9	Acid ceramidase; Belongs to the acid ceramidase family.	Ceramide glucosyltransferase isoform X1.	0.936
CLIC4	GRXCR2	A0A3Q0G7I8	A0A3Q0H4K0	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	Glutaredoxin domain-containing cysteine-rich protein 2 isoform X1.	0.419
CLIC4	PPP1R18	A0A3Q0G7I8	A0A1U7SQY4	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family.	LOW QUALITY PROTEIN: phostensin.	0.437
CLRN1	USH1C	A0A1U7SAR7	A0A3Q0GPT5	Clarin-1.	Harmonin.	0.453
CLRN1	WHRN	A0A1U7SAR7	A0A1U7S4T7	Clarin-1.	Whirlin.	0.454
DLL1	FOXN1	A0A1U7RQC2	A0A1U7SJD0	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Forkhead box protein N1 isoform X1.	0.435
DLL1	JAG1	A0A1U7RQC2	A0A1U7SGP5	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.541
DLL1	JAG2	A0A1U7RQC2	A0A1U7SAL7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.406
DLL1	MYO6	A0A1U7RQC2	A0A1U7RWZ5	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.410
DLX3	FOXN1	A0A1U7RSU1	A0A1U7SJD0	Homeobox protein DLX-3.	Forkhead box protein N1 isoform X1.	0.540
ERCC2	ERCC3	A0A3Q0HEJ9	A0A1U7RT04	General transcription and DNA repair factor IIH helicase subunit XPD.	General transcription and DNA repair factor IIH helicase subunit XPB.	0.999
ERCC2	LOC102381382	A0A3Q0HEJ9	A0A1U8D0V4	General transcription and DNA repair factor IIH helicase subunit XPD.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.449
ERCC2	MED1	A0A3Q0HEJ9	A0A1U8D3S0	General transcription and DNA repair factor IIH helicase subunit XPD.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.449
ERCC3	ERCC2	A0A1U7RT04	A0A3Q0HEJ9	General transcription and DNA repair factor IIH helicase subunit XPB.	General transcription and DNA repair factor IIH helicase subunit XPD.	0.999
ERCC3	LOC102381382	A0A1U7RT04	A0A1U8D0V4	General transcription and DNA repair factor IIH helicase subunit XPB.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.560
ERCC3	MED1	A0A1U7RT04	A0A1U8D3S0	General transcription and DNA repair factor IIH helicase subunit XPB.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.560
FA2H	UGCG	A0A1U7RLG6	A0A3Q0GYE9	Fatty acid 2-hydroxylase; Belongs to the sterol desaturase family.	Ceramide glucosyltransferase isoform X1.	0.417