60 items (Alligator sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAD	Bcl2-associated agonist of cell death. (153 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (460 aa)
	IGF2	Insulin-like growth factor II isoform X2. (268 aa)
	GPLD1	Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (869 aa)
	SOGA1	Protein SOGA1 isoform X1. (1488 aa)
	KAT2A	Histone acetyltransferase KAT2A. (712 aa)
	LOC106721793	E3 SUMO-protein ligase RanBP2 isoform X1. (3314 aa)
	LOC102386281	Glycine N-methyltransferase isoform X1. (221 aa)
	LEPR	Leptin receptor isoform X1. (1156 aa)
	FOXK2	Forkhead box protein K2 isoform X1. (699 aa)
	KAT2B	LOW QUALITY PROTEIN: histone acetyltransferase KAT2B. (758 aa)
	LOC102368372	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (329 aa)
	LOC112550855	Leucine carboxyl methyltransferase 1-like. (94 aa)
	C1QTNF6	Complement C1q tumor necrosis factor-related protein 6 isoform X3. (341 aa)
	DDB1	DNA damage-binding protein 1. (1130 aa)
	OGT	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (930 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (447 aa)
	USP7	Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1056 aa)
	PDK2	Protein-serine/threonine kinase. (343 aa)
	RORA	Nuclear receptor ROR-alpha. (472 aa)
	DGKQ	Diacylglycerol kinase. (845 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (52 aa)
	MIDN	LOW QUALITY PROTEIN: midnolin. (507 aa)
	SIRT6	NAD-dependent protein deacetylase sirtuin-6. (285 aa)
	LOC102380800	General transcription factor II-I repeat domain-containing protein 2A-like. (538 aa)
	SIRT7	NAD-dependent protein deacetylase sirtuin-7. (304 aa)
	BCKDK	Protein-serine/threonine kinase. (383 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (397 aa)
	LOC102377068	General transcription factor II-I repeat domain-containing protein 2A-like. (435 aa)
	RORC	Nuclear receptor ROR-gamma isoform X1. (542 aa)
	ZNF692	Zinc finger protein 692 isoform X1. (659 aa)
	MLYCD	malonyl-CoA decarboxylase, mitochondrial. (429 aa)
	LOC106723050	General transcription factor II-I repeat domain-containing protein 2B-like. (719 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (165 aa)
	SLC35B4	UDP-xylose and UDP-N-acetylglucosamine transporter. (374 aa)
	FOXK1	Forkhead box protein K1. (607 aa)
	IGFBP4	Insulin-like growth factor-binding protein 4. (256 aa)
	EP300	Histone acetyltransferase p300 isoform X1. (2149 aa)
	PRKN	RBR-type E3 ubiquitin transferase. (504 aa)
	ACADM	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial. (419 aa)
	SESN2	Sestrin-2 isoform X1. (559 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
	DUSP12	Dual specificity protein phosphatase 12. (210 aa)
	LOC102384812	Integumentary mucin C.1-like. (249 aa)
	PTH	Parathyroid hormone. (127 aa)
	PDK4	Protein-serine/threonine kinase. (436 aa)
	C1QTNF1	Complement C1q tumor necrosis factor-related protein 1. (270 aa)
	FAM3C	Protein FAM3C isoform X1. (227 aa)
	SLC45A3	Solute carrier family 45 member 3. (567 aa)
	LOC102371924	General transcription factor II-I repeat domain-containing protein 2-like. (663 aa)
	MST1	Hepatocyte growth factor-like protein isoform X1; Belongs to the peptidase S1 family. Plasminogen subfamily. (705 aa)
	FAM3A	Protein FAM3A isoform X1. (232 aa)
	ADIPOQ	Adiponectin. (243 aa)
	LOC102369647	Alpha-1-antitrypsin-like protein CM55-MM; Belongs to the serpin family. (423 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
	CRY1	Cryptochrome-1. (620 aa)
	PDK1	Protein-serine/threonine kinase. (382 aa)
	PDK3	Protein-serine/threonine kinase. (360 aa)
	LOC102383279	Cytochrome c oxidase assembly protein COX11, mitochondrial. (171 aa)
	C1QTNF12	Adipolin isoform X1. (320 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACADM	PPARA	A0A1U8CZP5	A0A1U7SL46	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial.	Peroxisome proliferator-activated receptor alpha isoform X1.	0.416
ADIPOQ	LEP	A0A1U7RYL6	A0A1U8DFZ0	Adiponectin.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.804
ADIPOQ	LEPR	A0A1U7RYL6	A0A3Q0H8E2	Adiponectin.	Leptin receptor isoform X1.	0.546
ADIPOQ	PPARA	A0A1U7RYL6	A0A1U7SL46	Adiponectin.	Peroxisome proliferator-activated receptor alpha isoform X1.	0.585
ADIPOQ	SIRT1	A0A1U7RYL6	A0A1U7RVX8	Adiponectin.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.543
DDB1	EP300	A0A3Q0GSF5	A0A1U8D7N2	DNA damage-binding protein 1.	Histone acetyltransferase p300 isoform X1.	0.477
DDB1	SIRT1	A0A3Q0GSF5	A0A1U7RVX8	DNA damage-binding protein 1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.402
DDB1	SIRT7	A0A3Q0GSF5	A0A3Q0FYZ0	DNA damage-binding protein 1.	NAD-dependent protein deacetylase sirtuin-7.	0.522
DDB1	USP7	A0A3Q0GSF5	A0A3Q0GL13	DNA damage-binding protein 1.	Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family.	0.577
EP300	DDB1	A0A1U8D7N2	A0A3Q0GSF5	Histone acetyltransferase p300 isoform X1.	DNA damage-binding protein 1.	0.477
EP300	KAT2A	A0A1U8D7N2	A0A3Q0HEA7	Histone acetyltransferase p300 isoform X1.	Histone acetyltransferase KAT2A.	0.985
EP300	KAT2B	A0A1U8D7N2	A0A3Q0H2L9	Histone acetyltransferase p300 isoform X1.	LOW QUALITY PROTEIN: histone acetyltransferase KAT2B.	0.985
EP300	PPARA	A0A1U8D7N2	A0A1U7SL46	Histone acetyltransferase p300 isoform X1.	Peroxisome proliferator-activated receptor alpha isoform X1.	0.730
EP300	RORA	A0A1U8D7N2	A0A3Q0GAS5	Histone acetyltransferase p300 isoform X1.	Nuclear receptor ROR-alpha.	0.529
EP300	RORC	A0A1U8D7N2	A0A3Q0FKY7	Histone acetyltransferase p300 isoform X1.	Nuclear receptor ROR-gamma isoform X1.	0.529
EP300	SIRT1	A0A1U8D7N2	A0A1U7RVX8	Histone acetyltransferase p300 isoform X1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.711
EP300	TP53	A0A1U8D7N2	A0A3Q0FUE5	Histone acetyltransferase p300 isoform X1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.999
FOXK1	OGT	A0A1U8DCX6	A0A3Q0GN41	Forkhead box protein K1.	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit.	0.714
FOXK2	OGT	A0A3Q0H6A2	A0A3Q0GN41	Forkhead box protein K2 isoform X1.	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit.	0.714
IGF2	IGFBP4	A0A3Q0HL91	A0A1U8DCM8	Insulin-like growth factor II isoform X2.	Insulin-like growth factor-binding protein 4.	0.692