52 items (Alligator sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ABCG1	ATP-binding cassette sub-family G member 1. (677 aa)
	SEC14L5	SEC14-like protein 5. (709 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
	ASAH1	Acid ceramidase; Belongs to the acid ceramidase family. (393 aa)
	PODN	Podocan. (600 aa)
	LOC102384045	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
	SEC14L2	SEC14-like protein 2. (409 aa)
	STARD4	stAR-related lipid transfer protein 4 isoform X1. (207 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
	SNAI2	Zinc finger protein SNAI2. (268 aa)
	LOC102369647	Alpha-1-antitrypsin-like protein CM55-MM; Belongs to the serpin family. (423 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (287 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	LOC102374436	Nuclear receptor subfamily 0 group B member 2-like. (303 aa)
	CGA	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	DKK3	Dickkopf-related protein 3. (290 aa)
	APOB	Apolipoprotein B-100. (3654 aa)
	REST	RE1-silencing transcription factor. (894 aa)
	LAMTOR1	Ragulator complex protein LAMTOR1. (161 aa)
	LOC102367890	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (348 aa)
	LOC102373750	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	LOC102374014	Erlin-1 isoform X3. (294 aa)
	LOC102384651	Apolipoprotein B-100-like. (991 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
	DAB2	Disabled homolog 2. (703 aa)
	TTC39B	Tetratricopeptide repeat protein 39B isoform X1. (606 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (165 aa)
	LOC102378738	Tumor necrosis factor. (231 aa)
	H6PD	LOW QUALITY PROTEIN: GDH/6PGL endoplasmic bifunctional protein. (793 aa)
	DDX20	Probable ATP-dependent RNA helicase DDX20; Belongs to the DEAD box helicase family. (778 aa)
	RORC	Nuclear receptor ROR-gamma isoform X1. (542 aa)
	SCAP	Sterol regulatory element-binding protein cleavage-activating protein isoform X1. (1342 aa)
	EPHX2	Bifunctional epoxide hydrolase 2. (509 aa)
	FGFR4	Fibroblast growth factor receptor 4 isoform X1. (647 aa)
	LPCAT3	Lysophospholipid acyltransferase 5 isoform X1; Belongs to the membrane-bound acyltransferase family. (514 aa)
	ARMC5	Armadillo repeat-containing protein 5. (1001 aa)
	ARV1	Protein ARV1. (228 aa)
	DKKL1	Dickkopf-like protein 1 isoform X1. (415 aa)
	SNAI1	Zinc finger protein SNAI1. (197 aa)
	DGKQ	Diacylglycerol kinase. (845 aa)
	RORA	Nuclear receptor ROR-alpha. (472 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1 isoform X1. (637 aa)
	SREBF1	Sterol regulatory element-binding protein 1 isoform X2. (1237 aa)
	LOC102381473	LOW QUALITY PROTEIN: tetratricopeptide repeat protein 39A-like. (605 aa)
	TTC39A	Tetratricopeptide repeat protein 39A isoform X1. (581 aa)
	ABCG4	ATP-binding cassette sub-family G member 4 isoform X1. (596 aa)
	BMP6	Bone morphogenetic protein 6 isoform X1. (320 aa)
	SREBF2	Sterol regulatory element-binding protein 2 isoform X1. (1096 aa)
	APOA5	Apolipoprotein A-V isoform X1. (365 aa)
	LOC102370558	Erlin-2 isoform X1. (356 aa)
	RUSC1	RUN and SH3 domain-containing protein 1. (1198 aa)
	IGF2	Insulin-like growth factor II isoform X2. (268 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA5	APOB	A0A3Q0H6S2	A0A1U7SB35	Apolipoprotein A-V isoform X1.	Apolipoprotein B-100.	0.579
APOA5	LOC102384651	A0A3Q0H6S2	A0A1U7SVD5	Apolipoprotein A-V isoform X1.	Apolipoprotein B-100-like.	0.579
APOB	APOA5	A0A1U7SB35	A0A3Q0H6S2	Apolipoprotein B-100.	Apolipoprotein A-V isoform X1.	0.579
APOB	DAB2	A0A1U7SB35	A0A1U8D9B0	Apolipoprotein B-100.	Disabled homolog 2.	0.557
APOB	LOC102384651	A0A1U7SB35	A0A1U7SVD5	Apolipoprotein B-100.	Apolipoprotein B-100-like.	0.907
DAB2	APOB	A0A1U8D9B0	A0A1U7SB35	Disabled homolog 2.	Apolipoprotein B-100.	0.557
DAB2	DKK3	A0A1U8D9B0	A0A1U7SAI7	Disabled homolog 2.	Dickkopf-related protein 3.	0.432
DAB2	LOC102384651	A0A1U8D9B0	A0A1U7SVD5	Disabled homolog 2.	Apolipoprotein B-100-like.	0.557
DKK3	DAB2	A0A1U7SAI7	A0A1U8D9B0	Dickkopf-related protein 3.	Disabled homolog 2.	0.432
FGF1	FGF19	A0A1U7S0Q8	A0A1U7RI14	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.516
FGF1	FGFR4	A0A1U7S0Q8	A0A3Q0FPI0	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor receptor 4 isoform X1.	0.979
FGF19	FGF1	A0A1U7RI14	A0A1U7S0Q8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.516
FGF19	FGFR4	A0A1U7RI14	A0A3Q0FPI0	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor 4 isoform X1.	0.974
FGF19	LOC102373750	A0A1U7RI14	A0A1U7SHB4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.615
FGFR4	FGF1	A0A3Q0FPI0	A0A1U7S0Q8	Fibroblast growth factor receptor 4 isoform X1.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.979
FGFR4	FGF19	A0A3Q0FPI0	A0A1U7RI14	Fibroblast growth factor receptor 4 isoform X1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.974
FGFR4	IGF2	A0A3Q0FPI0	A0A3Q0HL91	Fibroblast growth factor receptor 4 isoform X1.	Insulin-like growth factor II isoform X2.	0.666
FGFR4	LOC102373750	A0A3Q0FPI0	A0A1U7SHB4	Fibroblast growth factor receptor 4 isoform X1.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.442
IGF2	FGFR4	A0A3Q0HL91	A0A3Q0FPI0	Insulin-like growth factor II isoform X2.	Fibroblast growth factor receptor 4 isoform X1.	0.666
IGF2	LEP	A0A3Q0HL91	A0A1U8DFZ0	Insulin-like growth factor II isoform X2.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.430