52 items (Alligator sinensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LCAT	Phosphatidylcholine-sterol acyltransferase. (580 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1 isoform X1. (637 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (128 aa)
	ANGPTL3	Angiopoietin-related protein 3. (462 aa)
	MTTP	Microsomal triglyceride transfer protein large subunit. (893 aa)
	LIMA1	LIM domain and actin-binding protein 1 isoform X1. (763 aa)
	SIRT1	NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
	LDLRAP1	Low density lipoprotein receptor adapter protein 1 isoform X1. (332 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	TMEM97	Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (171 aa)
	ABCG4	ATP-binding cassette sub-family G member 4 isoform X1. (596 aa)
	IL18	Interleukin-18 isoform X1. (231 aa)
	TTC39A	Tetratricopeptide repeat protein 39A isoform X1. (581 aa)
	LOC102381473	LOW QUALITY PROTEIN: tetratricopeptide repeat protein 39A-like. (605 aa)
	EPHX2	Bifunctional epoxide hydrolase 2. (509 aa)
	LOC102373750	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
	LOC102384651	Apolipoprotein B-100-like. (991 aa)
	SLC37A4	Glucose-6-phosphate exchanger SLC37A4 isoform X1. (435 aa)
	LIPC	Hepatic triacylglycerol lipase. (498 aa)
	TTC39B	Tetratricopeptide repeat protein 39B isoform X1. (606 aa)
	APOA4	Apolipoprotein A-IV isoform X1. (396 aa)
	ABCG8	ATP-binding cassette sub-family G member 8. (677 aa)
	NR1H4	Bile acid receptor. (465 aa)
	PLA2G12B	Group XIIB secretory phospholipase A2-like protein isoform X1. (202 aa)
	LOC102382111	Microsomal triglyceride transfer protein-like isoform X1. (888 aa)
	NUS1	Dehydrodolichyl diphosphate synthase complex subunit NUS1. (150 aa)
	LOC102381511	RNA-binding Raly-like protein. (196 aa)
	NPC1L1	LOW QUALITY PROTEIN: NPC1-like intracellular cholesterol transporter 1. (1385 aa)
	XBP1	X-box-binding protein 1. (137 aa)
	NR1H2	Oxysterols receptor LXR-beta isoform X1. (438 aa)
	COMMD9	COMM domain-containing protein 9. (198 aa)
	LOC102386823	25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (513 aa)
	SCARB1	Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (473 aa)
	ABCG5	ATP-binding cassette sub-family G member 5. (638 aa)
	MED13	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2176 aa)
	PLA2G10	Phospholipase A(2). (182 aa)
	RALYL	RNA-binding Raly-like protein isoform X2. (293 aa)
	LOC102368598	Phospholipase A(2). (226 aa)
	GRAMD1B	GRAM domain-containing protein 1B isoform X1. (885 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1593 aa)
	LOC102387409	Apolipoprotein A-II-like. (103 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	FGFR4	Fibroblast growth factor receptor 4 isoform X1. (647 aa)
	LOC102388360	24-hydroxycholesterol 7-alpha-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (468 aa)
	NR1H3	LOW QUALITY PROTEIN: oxysterols receptor LXR-alpha. (414 aa)
	ABCG1	ATP-binding cassette sub-family G member 1. (677 aa)
	MYLIP	E3 ubiquitin-protein ligase MYLIP. (380 aa)
	RALY	RNA-binding protein Raly isoform X1. (320 aa)
	APOA5	Apolipoprotein A-V isoform X1. (365 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (666 aa)
	APOB	Apolipoprotein B-100. (3654 aa)
	LAMTOR1	Ragulator complex protein LAMTOR1. (161 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG1	ABCG5	A0A3Q0HLL6	A0A1U7S1S3	ATP-binding cassette sub-family G member 1.	ATP-binding cassette sub-family G member 5.	0.783
ABCG4	ABCG5	A0A3Q0GVI2	A0A1U7S1S3	ATP-binding cassette sub-family G member 4 isoform X1.	ATP-binding cassette sub-family G member 5.	0.783
ABCG5	ABCG1	A0A1U7S1S3	A0A3Q0HLL6	ATP-binding cassette sub-family G member 5.	ATP-binding cassette sub-family G member 1.	0.783
ABCG5	ABCG4	A0A1U7S1S3	A0A3Q0GVI2	ATP-binding cassette sub-family G member 5.	ATP-binding cassette sub-family G member 4 isoform X1.	0.783
ABCG5	ABCG8	A0A1U7S1S3	A0A1U8DCY8	ATP-binding cassette sub-family G member 5.	ATP-binding cassette sub-family G member 8.	0.999
ABCG5	APOA4	A0A1U7S1S3	A0A1U8DBC9	ATP-binding cassette sub-family G member 5.	Apolipoprotein A-IV isoform X1.	0.404
ABCG5	EPHX2	A0A1U7S1S3	A0A3Q0FP79	ATP-binding cassette sub-family G member 5.	Bifunctional epoxide hydrolase 2.	0.401
ABCG5	LOC102373750	A0A1U7S1S3	A0A1U7SHB4	ATP-binding cassette sub-family G member 5.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.620
ABCG5	LOC102386823	A0A1U7S1S3	A0A1U7R8L1	ATP-binding cassette sub-family G member 5.	25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family.	0.440
ABCG5	LOC102388360	A0A1U7S1S3	A0A1U7S2W4	ATP-binding cassette sub-family G member 5.	24-hydroxycholesterol 7-alpha-hydroxylase isoform X1; Belongs to the cytochrome P450 family.	0.441
ABCG5	MTTP	A0A1U7S1S3	A0A1U7S102	ATP-binding cassette sub-family G member 5.	Microsomal triglyceride transfer protein large subunit.	0.416
ABCG5	NPC1	A0A1U7S1S3	A0A3Q0FVZ6	ATP-binding cassette sub-family G member 5.	NPC intracellular cholesterol transporter 1.	0.408
ABCG5	NPC1L1	A0A1U7S1S3	A0A3Q0FP67	ATP-binding cassette sub-family G member 5.	LOW QUALITY PROTEIN: NPC1-like intracellular cholesterol transporter 1.	0.408
ABCG5	NR1H2	A0A1U7S1S3	A0A1U7RL56	ATP-binding cassette sub-family G member 5.	Oxysterols receptor LXR-beta isoform X1.	0.436
ABCG5	NR1H3	A0A1U7S1S3	A0A3Q0HPM1	ATP-binding cassette sub-family G member 5.	LOW QUALITY PROTEIN: oxysterols receptor LXR-alpha.	0.436
ABCG5	NR1H4	A0A1U7S1S3	A0A1U8DE20	ATP-binding cassette sub-family G member 5.	Bile acid receptor.	0.575
ABCG8	ABCG5	A0A1U8DCY8	A0A1U7S1S3	ATP-binding cassette sub-family G member 8.	ATP-binding cassette sub-family G member 5.	0.999
ABCG8	APOB	A0A1U8DCY8	A0A1U7SB35	ATP-binding cassette sub-family G member 8.	Apolipoprotein B-100.	0.603
ABCG8	LOC102373750	A0A1U8DCY8	A0A1U7SHB4	ATP-binding cassette sub-family G member 8.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.601
ABCG8	LOC102386823	A0A1U8DCY8	A0A1U7R8L1	ATP-binding cassette sub-family G member 8.	25-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family.	0.436