STRINGSTRING
LCAT LCAT NR1D1 NR1D1 CAV1 CAV1 ANGPTL3 ANGPTL3 MTTP MTTP LIMA1 LIMA1 SIRT1 SIRT1 LDLRAP1 LDLRAP1 CAV3 CAV3 TMEM97 TMEM97 ABCG4 ABCG4 IL18 IL18 TTC39A TTC39A LOC102381473 LOC102381473 EPHX2 EPHX2 LOC102373750 LOC102373750 LOC102384651 LOC102384651 SLC37A4 SLC37A4 LIPC LIPC TTC39B TTC39B APOA4 APOA4 ABCG8 ABCG8 NR1H4 NR1H4 PLA2G12B PLA2G12B LOC102382111 LOC102382111 NUS1 NUS1 LOC102381511 LOC102381511 NPC1L1 NPC1L1 XBP1 XBP1 NR1H2 NR1H2 COMMD9 COMMD9 LOC102386823 LOC102386823 SCARB1 SCARB1 ABCG5 ABCG5 MED13 MED13 PLA2G10 PLA2G10 RALYL RALYL LOC102368598 LOC102368598 GRAMD1B GRAMD1B LRP5 LRP5 LOC102387409 LOC102387409 NPC1 NPC1 FGFR4 FGFR4 LOC102388360 LOC102388360 NR1H3 NR1H3 ABCG1 ABCG1 MYLIP MYLIP RALY RALY APOA5 APOA5 PCSK9 PCSK9 APOB APOB LAMTOR1 LAMTOR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LCATPhosphatidylcholine-sterol acyltransferase. (580 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X1. (637 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (128 aa)
ANGPTL3Angiopoietin-related protein 3. (462 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (893 aa)
LIMA1LIM domain and actin-binding protein 1 isoform X1. (763 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1 isoform X1. (332 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TMEM97Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (171 aa)
ABCG4ATP-binding cassette sub-family G member 4 isoform X1. (596 aa)
IL18Interleukin-18 isoform X1. (231 aa)
TTC39ATetratricopeptide repeat protein 39A isoform X1. (581 aa)
LOC102381473LOW QUALITY PROTEIN: tetratricopeptide repeat protein 39A-like. (605 aa)
EPHX2Bifunctional epoxide hydrolase 2. (509 aa)
LOC102373750Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (512 aa)
LOC102384651Apolipoprotein B-100-like. (991 aa)
SLC37A4Glucose-6-phosphate exchanger SLC37A4 isoform X1. (435 aa)
LIPCHepatic triacylglycerol lipase. (498 aa)
TTC39BTetratricopeptide repeat protein 39B isoform X1. (606 aa)
APOA4Apolipoprotein A-IV isoform X1. (396 aa)
ABCG8ATP-binding cassette sub-family G member 8. (677 aa)
NR1H4Bile acid receptor. (465 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein isoform X1. (202 aa)
LOC102382111Microsomal triglyceride transfer protein-like isoform X1. (888 aa)
NUS1Dehydrodolichyl diphosphate synthase complex subunit NUS1. (150 aa)
LOC102381511RNA-binding Raly-like protein. (196 aa)
NPC1L1LOW QUALITY PROTEIN: NPC1-like intracellular cholesterol transporter 1. (1385 aa)
XBP1X-box-binding protein 1. (137 aa)
NR1H2Oxysterols receptor LXR-beta isoform X1. (438 aa)
COMMD9COMM domain-containing protein 9. (198 aa)
LOC10238682325-hydroxycholesterol 7-alpha-hydroxylase; Belongs to the cytochrome P450 family. (513 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (473 aa)
ABCG5ATP-binding cassette sub-family G member 5. (638 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2176 aa)
PLA2G10Phospholipase A(2). (182 aa)
RALYLRNA-binding Raly-like protein isoform X2. (293 aa)
LOC102368598Phospholipase A(2). (226 aa)
GRAMD1BGRAM domain-containing protein 1B isoform X1. (885 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1593 aa)
LOC102387409Apolipoprotein A-II-like. (103 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
FGFR4Fibroblast growth factor receptor 4 isoform X1. (647 aa)
LOC10238836024-hydroxycholesterol 7-alpha-hydroxylase isoform X1; Belongs to the cytochrome P450 family. (468 aa)
NR1H3LOW QUALITY PROTEIN: oxysterols receptor LXR-alpha. (414 aa)
ABCG1ATP-binding cassette sub-family G member 1. (677 aa)
MYLIPE3 ubiquitin-protein ligase MYLIP. (380 aa)
RALYRNA-binding protein Raly isoform X1. (320 aa)
APOA5Apolipoprotein A-V isoform X1. (365 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (666 aa)
APOBApolipoprotein B-100. (3654 aa)
LAMTOR1Ragulator complex protein LAMTOR1. (161 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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