STRINGSTRING
CREB1 CREB1 MYBBP1A MYBBP1A HDAC3 HDAC3 PTN PTN PSPC1 PSPC1 PPARA PPARA NFIL3 NFIL3 THRAP3 THRAP3 CCDC90B CCDC90B ATOH7 ATOH7 LOC102381778 LOC102381778 LOC102382695 LOC102382695 CSNK1D CSNK1D PROK2 PROK2 NR1D2 NR1D2 LOC102372634 LOC102372634 LOC106722193 LOC106722193 OPN4 OPN4 LOC102384287 LOC102384287 ID2 ID2 LOC102368447 LOC102368447 LOC102384928 LOC102384928 EP300 EP300 HTR7 HTR7 HUWE1 HUWE1 KIAA2013 KIAA2013 DHX9 DHX9 NPAS2 NPAS2 CREBBP CREBBP PRMT5 PRMT5 LOC102373120 LOC102373120 TIMELESS TIMELESS RORC RORC TOP1 TOP1 GPR157 GPR157 AXL AXL LOC102378662 LOC102378662 LOC102381859 LOC102381859 SGPL1 SGPL1 ARNTL ARNTL LOC102374703 LOC102374703 CIART CIART LOC112548358 LOC112548358 TP53 TP53 LOC102374542 LOC102374542 PER1 PER1 DDX5 DDX5 ADNP ADNP SIRT6 SIRT6 NAGLU NAGLU NCOR2 NCOR2 AHR AHR FBXW7 FBXW7 BTBD9 BTBD9 HLF HLF GPR176 GPR176 EREG EREG CLOCK CLOCK LOC102372873 LOC102372873 LGR4 LGR4 LOC102381221 LOC102381221 RORA RORA HOMER1 HOMER1 ROCK2 ROCK2 CUNH3orf70 CUNH3orf70 DNM1L DNM1L SUV39H2 SUV39H2 NGFR NGFR NR1D1 NR1D1 NUDT12 NUDT12 OGT OGT ESR1 ESR1 SLIT3 SLIT3 NFYA NFYA RAI1 RAI1 PRKAA2 PRKAA2 DDB1 DDB1 PPARGC1A PPARGC1A LOC102378300 LOC102378300 DBP DBP KDM8 KDM8 CRY2 CRY2 NAMPT NAMPT ADCY1 ADCY1 MAPK9 MAPK9 SFPQ SFPQ LOC102373234 LOC102373234 KLF10 KLF10 CRTC1 CRTC1 NDUFA9 NDUFA9 ENOX2 ENOX2 HNF1B HNF1B SLIT2 SLIT2 LOC102384121 LOC102384121 MTOR MTOR PIWIL2 PIWIL2 ATF5 ATF5 LOC102377832 LOC102377832 LOC102384541 LOC102384541 TNFRSF11A TNFRSF11A SP1 SP1 SETX SETX NTRK1 NTRK1 PER3 PER3 BHLHE41 BHLHE41 LOC102381255 LOC102381255 FZD4 FZD4 PPP1CB PPP1CB EDN2 EDN2 TRPM2 TRPM2 NCOR1 NCOR1 MYCBP2 MYCBP2 ATG7 ATG7 PAX4 PAX4 NOCT NOCT NMS NMS LOC102382509 LOC102382509 CSNK1E CSNK1E FSHB FSHB MAPK8 MAPK8 FBXW9 FBXW9 METTL3 METTL3 ATF4 ATF4 GPR149 GPR149 ENOX1 ENOX1 GRIN3A GRIN3A CIPC CIPC PRKAA1 PRKAA1 DRD2 DRD2 ENPP2 ENPP2 PPP1CA PPP1CA EGR3 EGR3 RORB RORB LOC102372737 LOC102372737 FSHR FSHR GAS2 GAS2 PPP1CC PPP1CC CARTPT CARTPT AANAT AANAT EGR2 EGR2 NR0B2 NR0B2 LOC102383933 LOC102383933 MC3R MC3R PML PML LOC102377626 LOC102377626 ZNF830 ZNF830 NONO NONO TNFAIP6 TNFAIP6 PTX3 PTX3 INHBA INHBA LOC102370063 LOC102370063 LOC102378108 LOC102378108 MDK MDK PPARG PPARG LOC102385821 LOC102385821 DRD4 DRD4 CRY1 CRY1 LOC102383432 LOC102383432 SIRT1 SIRT1 LOC102375552 LOC102375552 LOC102382870 LOC102382870 LOC102378535 LOC102378535 NRIP1 NRIP1 SUV39H1 SUV39H1 BHLHE40 BHLHE40 LOC102372380 LOC102372380 CDK1 CDK1 MTTP MTTP ZPBP2 ZPBP2 PAM PAM DTL DTL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB1Cyclic AMP-responsive element-binding protein 1. (327 aa)
MYBBP1AMyb-binding protein 1A. (1165 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (405 aa)
PTNLOW QUALITY PROTEIN: pleiotrophin. (244 aa)
PSPC1Paraspeckle component 1. (518 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
NFIL3Nuclear factor interleukin-3-regulated protein. (447 aa)
THRAP3Thyroid hormone receptor-associated protein 3. (962 aa)
CCDC90BCoiled-coil domain-containing protein 90B, mitochondrial isoform X1. (246 aa)
ATOH7Protein atonal homolog 7. (151 aa)
LOC102381778Lysine-specific demethylase 5B. (981 aa)
LOC102382695Neuronal PAS domain-containing protein 2. (698 aa)
CSNK1DCasein kinase I. (442 aa)
PROK2Prokineticin-2. (88 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X2. (588 aa)
LOC102372634DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (421 aa)
LOC106722193Nuclear factor interleukin-3-regulated protein-like. (394 aa)
OPN4LOW QUALITY PROTEIN: melanopsin; Belongs to the G-protein coupled receptor 1 family. (315 aa)
LOC102384287Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family. (182 aa)
ID2DNA-binding protein inhibitor ID-2. (271 aa)
LOC102368447S phase cyclin A-associated protein in the endoplasmic reticulum-like. (567 aa)
LOC102384928Aryl hydrocarbon receptor-like. (1015 aa)
EP300Histone acetyltransferase p300 isoform X1. (2149 aa)
HTR75-hydroxytryptamine receptor 7. (418 aa)
HUWE1LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HUWE1. (4398 aa)
KIAA2013Uncharacterized protein KIAA2013 homolog. (358 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1209 aa)
NPAS2Neuronal PAS domain-containing protein 2 isoform X1. (825 aa)
CREBBPCREB-binding protein. (2468 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (557 aa)
LOC102373120Receptor of activated protein C kinase 1. (333 aa)
TIMELESSLOW QUALITY PROTEIN: protein timeless homolog. (1194 aa)
RORCNuclear receptor ROR-gamma isoform X1. (542 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (751 aa)
GPR157G-protein coupled receptor 157 isoform X1. (385 aa)
AXLTyrosine-protein kinase receptor UFO. (558 aa)
LOC102378662F-box/WD repeat-containing protein 7-like. (769 aa)
LOC102381859Sphingosine-1-phosphate lyase 1-like. (193 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (438 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X1. (680 aa)
LOC102374703Lysine-specific demethylase 5B isoform X1. (530 aa)
CIARTCircadian-associated transcriptional repressor isoform X1. (467 aa)
LOC112548358Neuronal PAS domain-containing protein 2-like. (191 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (397 aa)
LOC102374542Mitogen-activated protein kinase. (464 aa)
PER1Period circadian protein homolog 1 isoform X1. (1311 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (611 aa)
ADNPActivity-dependent neuroprotector homeobox protein isoform X1. (1122 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (285 aa)
NAGLUalpha-N-acetylglucosaminidase. (711 aa)
NCOR2Nuclear receptor corepressor 2 isoform X1. (2608 aa)
AHRLOW QUALITY PROTEIN: aryl hydrocarbon receptor. (731 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (762 aa)
BTBD9BTB/POZ domain-containing protein 9 isoform X1. (671 aa)
HLFHepatic leukemia factor isoform X1. (278 aa)
GPR176G-protein coupled receptor 176 isoform X1. (529 aa)
EREGProepiregulin. (173 aa)
CLOCKCircadian locomoter output cycles protein kaput. (883 aa)
LOC102372873Protein PML-like isoform X1. (652 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1. (887 aa)
LOC102381221Aryl hydrocarbon receptor-like isoform X1. (1134 aa)
RORANuclear receptor ROR-alpha. (472 aa)
HOMER1Homer protein homolog 1 isoform X1. (367 aa)
ROCK2Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1455 aa)
CUNH3orf70UPF0524 protein C3orf70 homolog. (195 aa)
DNM1LDynamin-1-like protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (731 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (451 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X1. (637 aa)
NUDT12LOW QUALITY PROTEIN: peroxisomal NADH pyrophosphatase NUDT12. (470 aa)
OGTUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit. (930 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
SLIT3Slit homolog 3 protein isoform X1. (1369 aa)
NFYANuclear transcription factor Y subunit alpha isoform X1. (401 aa)
RAI1LOW QUALITY PROTEIN: retinoic acid-induced protein 1. (1935 aa)
PRKAA2Non-specific serine/threonine protein kinase. (461 aa)
DDB1DNA damage-binding protein 1. (1130 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1. (810 aa)
LOC102378300Tumor necrosis factor receptor superfamily member 16-like. (384 aa)
DBPD site-binding protein isoform X1. (434 aa)
KDM8jmjC domain-containing protein 5. (268 aa)
CRY2Cryptochrome-2. (547 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (504 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
SFPQSplicing factor, proline- and glutamine-rich. (460 aa)
LOC102373234Nuclear receptor ROR-beta-like isoform X1. (467 aa)
KLF10Krueppel-like factor 10 isoform X1. (497 aa)
CRTC1CREB-regulated transcription coactivator 1 isoform X1. (611 aa)
NDUFA9NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial. (378 aa)
ENOX2ecto-NOX disulfide-thiol exchanger 2 isoform X1. (681 aa)
HNF1BHepatocyte nuclear factor 1-beta. (513 aa)
SLIT2Slit homolog 2 protein. (1435 aa)
LOC102384121S phase cyclin A-associated protein in the endoplasmic reticulum. (890 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2551 aa)
PIWIL2Piwi-like protein 2; Belongs to the argonaute family. (969 aa)
ATF5Cyclic AMP-dependent transcription factor ATF-5. (376 aa)
LOC102377832Nuclear receptor subfamily 1 group D member 1-like. (516 aa)
LOC102384541Slit homolog 3 protein-like. (114 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (669 aa)
SP1Transcription factor Sp1. (791 aa)
SETXProbable helicase senataxin isoform X1. (2872 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
PER3LOW QUALITY PROTEIN: period circadian protein homolog 3. (218 aa)
BHLHE41Class E basic helix-loop-helix protein 41 isoform X1. (231 aa)
LOC102381255RNA-binding protein 4B isoform X1. (364 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (450 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (326 aa)
EDN2Endothelin-2. (194 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1476 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2560 aa)
MYCBP2E3 ubiquitin-protein ligase MYCBP2. (4641 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (815 aa)
PAX4Paired box protein Pax-4. (434 aa)
NOCTNocturnin isoform X1. (417 aa)
NMSneuromedin-S. (79 aa)
LOC102382509Transmembrane protein FAM155A-like. (328 aa)
CSNK1ECasein kinase I isoform X1; Belongs to the protein kinase superfamily. (417 aa)
FSHBFollitropin subunit beta. (131 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FBXW9F-box/WD repeat-containing protein 9 isoform X1. (457 aa)
METTL3N6-adenosine-methyltransferase catalytic subunit; Belongs to the MT-A70-like family. (571 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4 isoform X1. (352 aa)
GPR149Probable G-protein coupled receptor 149. (736 aa)
ENOX1ecto-NOX disulfide-thiol exchanger 1 isoform X1. (623 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (885 aa)
CIPCCLOCK-interacting pacemaker isoform X1. (383 aa)
PRKAA1Non-specific serine/threonine protein kinase. (563 aa)
DRD2D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (910 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (301 aa)
EGR3Early growth response protein 3. (152 aa)
RORBNuclear receptor ROR-beta. (461 aa)
LOC102372737LOW QUALITY PROTEIN: period circadian protein homolog 2-like. (1315 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
GAS2Growth arrest-specific protein 2 isoform X1. (314 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
CARTPTCocaine- and amphetamine-regulated transcript protein. (69 aa)
AANATSerotonin N-acetyltransferase. (205 aa)
EGR2E3 SUMO-protein ligase EGR2. (357 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (266 aa)
LOC102383933Melanopsin-like. (546 aa)
MC3RMelanocortin receptor 3. (326 aa)
PMLProtein PML. (586 aa)
LOC102377626Cytochrome P450 1B1; Belongs to the cytochrome P450 family. (511 aa)
ZNF830Zinc finger protein 830 isoform X1. (362 aa)
NONOnon-POU domain-containing octamer-binding protein. (460 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (275 aa)
PTX3Pentraxin-related protein PTX3. (427 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (424 aa)
LOC1023700635-hydroxytryptamine receptor 7-like; Belongs to the G-protein coupled receptor 1 family. (426 aa)
LOC102378108F-box/LRR-repeat protein 21. (435 aa)
MDKMidkine isoform X1. (142 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
LOC102385821Tyrosine-protein kinase receptor. (363 aa)
DRD4D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CRY1Cryptochrome-1. (620 aa)
LOC102383432Lysine-specific demethylase 5A. (767 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1 isoform X1. (557 aa)
LOC102375552Lysine-specific demethylase 5A-like. (867 aa)
LOC102382870Cryptochrome-1-like. (530 aa)
LOC102378535Protein PML-like isoform X1. (852 aa)
NRIP1Nuclear receptor-interacting protein 1. (1162 aa)
SUV39H1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (417 aa)
BHLHE40Class E basic helix-loop-helix protein 40. (388 aa)
LOC102372380BDNF/NT-3 growth factors receptor. (415 aa)
CDK1LOW QUALITY PROTEIN: cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (311 aa)
MTTPMicrosomal triglyceride transfer protein large subunit. (893 aa)
ZPBP2Zona pellucida-binding protein 2. (353 aa)
PAMPeptidyl-glycine alpha-amidating monooxygenase isoform X1. (979 aa)
DTLDenticleless protein homolog isoform X1. (736 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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