(77 nodes) Negative regulation of epithelial cell proliferation network (Alligator sinensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	TRIM24	Transcription intermediary factor 1-alpha isoform X1. (951 aa)
	SULF1	Extracellular sulfatase Sulf-1 isoform X1. (1125 aa)
	IFT80	Intraflagellar transport protein 80 homolog isoform X1. (779 aa)
	LIMS1	LIM domain-containing protein. (417 aa)
	LOC102368462	Vascular endothelial growth factor receptor kdr-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1336 aa)
	WDR13	WD repeat-containing protein 13. (487 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3. (385 aa)
	PTPRK	Receptor-type tyrosine-protein phosphatase kappa. (1490 aa)
	ACVRL1	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
	VDR	Vitamin D3 receptor. (520 aa)
	RB1	Retinoblastoma-associated protein isoform X1. (905 aa)
	MMRN2	LOW QUALITY PROTEIN: multimerin-2. (1011 aa)
	NF1	Neurofibromin. (2861 aa)
	LIMS2	LIM domain-containing protein. (340 aa)
	FLT1	Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1238 aa)
	ZEB1	Zinc finger E-box-binding homeobox 1. (887 aa)
	FLCN	Folliculin. (576 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (199 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (615 aa)
	CASK	Peripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family. (932 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (128 aa)
	VASH1	Vasohibin-1. (347 aa)
	AR	Androgen receptor isoform X2. (430 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (440 aa)
	THBS1	Thrombospondin-1 isoform X1. (1213 aa)
	IFT172	Intraflagellar transport protein 172 homolog. (1775 aa)
	WDR77	Methylosome protein 50. (356 aa)
	DAB2	Disabled homolog 2. (703 aa)
	NLRC3	NLR family CARD domain-containing protein 3. (1093 aa)
	IFT57	Intraflagellar transport protein 57 homolog isoform X1. (346 aa)
	RGCC	Regulator of cell cycle RGCC. (131 aa)
	IL12A	Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (145 aa)
	SERPINF1	Pigment epithelium-derived factor; Belongs to the serpin family. (417 aa)
	HPN	Serine protease hepsin; Belongs to the peptidase S1 family. (430 aa)
	LOC102378738	Tumor necrosis factor. (231 aa)
	MTSS1	Metastasis suppressor protein 1 isoform X1. (827 aa)
	CPB2	Carboxypeptidase B2. (424 aa)
	PHOX2B	Paired mesoderm homeobox protein 2B. (155 aa)
	PPARD	Peroxisome proliferator-activated receptor delta isoform X1. (442 aa)
	BRCA2	Breast cancer type 2 susceptibility protein isoform X1. (3334 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1565 aa)
	LOC102381382	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
	TGFB1	Transforming growth factor beta-1. (235 aa)
	TINF2	TERF1-interacting nuclear factor 2 isoform X1. (359 aa)
	KRIT1	Krev interaction trapped protein 1 isoform X1. (736 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (170 aa)
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (566 aa)
	NKX3-1	Homeobox protein Nkx-3.1 isoform X1. (232 aa)
	AQP11	Aquaporin-11; Belongs to the MIP/aquaporin (TC 1.A.8) family. (220 aa)
	DRD2	D(2) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	AIMP1	Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X2. (319 aa)
	LOC102377648	Synaptojanin-2-binding protein. (145 aa)
	IFT52	Intraflagellar transport protein 52 homolog isoform X1. (445 aa)
	DUSP10	Dual specificity protein phosphatase 10. (479 aa)
	PAX6	Paired box protein Pax-6 isoform X1. (436 aa)
	EAF2	ELL-associated factor 2. (234 aa)
	IFT74	Intraflagellar transport protein 74 homolog isoform X1. (598 aa)
	GHRL	Appetite-regulating hormone isoform X1. (145 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	TBC1D31	TBC1 domain family member 31. (1091 aa)
	STK11	Serine/threonine-protein kinase STK11 isoform X1; Belongs to the protein kinase superfamily. (440 aa)
	PDCD10	Programmed cell death protein 10 isoform X1. (212 aa)
	EFNB2	ephrin-B2 isoform X1; Belongs to the ephrin family. (338 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	TNMD	Tenomodulin isoform X2. (318 aa)
	A4GNT	alpha-1,4-N-acetylglucosaminyltransferase. (341 aa)
	ETV4	ETS translocation variant 4. (299 aa)
	INTU	Protein inturned isoform X1. (912 aa)
	KDF1	Keratinocyte differentiation factor 1. (418 aa)
	PEX2	Peroxisome biogenesis factor 2. (324 aa)
	PTCH1	Protein patched homolog 1 isoform X1. (1326 aa)
	SAV1	Protein salvador homolog 1. (351 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
	CDC73	Parafibromin. (488 aa)
	APOH	Beta-2-glycoprotein 1. (350 aa)
	MCC	Colorectal mutant cancer protein isoform X1. (957 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	TGFB1	A0A3Q0H7X9	A0A1U7SS54	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta-1.	0.768
ACVRL1	TGFB2	A0A3Q0H7X9	A0A1U7REV2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.543
ACVRL1	TGFBR1	A0A3Q0H7X9	A0A3Q0G355	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.437
AR	CAV3	A0A3Q0G8Z2	A0A1U7RQL9	Androgen receptor isoform X2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.460
AR	LOC102381382	A0A3Q0G8Z2	A0A1U8D0V4	Androgen receptor isoform X2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.517
AR	MED1	A0A3Q0G8Z2	A0A1U8D3S0	Androgen receptor isoform X2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.517
AR	NKX3-1	A0A3Q0G8Z2	A0A1U7SB75	Androgen receptor isoform X2.	Homeobox protein Nkx-3.1 isoform X1.	0.592
ATP5F1A	LOC102381382	A0A1U7SEQ1	A0A1U8D0V4	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.799
ATP5F1A	MED1	A0A1U7SEQ1	A0A1U8D3S0	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.799
BRCA2	NF1	A0A1U8D5M6	A0A3Q0H536	Breast cancer type 2 susceptibility protein isoform X1.	Neurofibromin.	0.553
BRCA2	STK11	A0A1U8D5M6	A0A1U7RR66	Breast cancer type 2 susceptibility protein isoform X1.	Serine/threonine-protein kinase STK11 isoform X1; Belongs to the protein kinase superfamily.	0.548
CASK	LOC102377648	A0A3Q0GMP9	A0A1U7S6K0	Peripheral plasma membrane protein CASK isoform X1; Belongs to the MAGUK family.	Synaptojanin-2-binding protein.	0.519
CAV1	CAV2	A0A3Q0GJR4	A0A3Q0GP26	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV1	CAV3	A0A3Q0GJR4	A0A1U7RQL9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.961
CAV2	CAV1	A0A3Q0GP26	A0A3Q0GJR4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV2	CAV3	A0A3Q0GP26	A0A1U7RQL9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV3	AR	A0A1U7RQL9	A0A3Q0G8Z2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Androgen receptor isoform X2.	0.460
CAV3	CAV1	A0A1U7RQL9	A0A3Q0GJR4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.961
CAV3	CAV2	A0A1U7RQL9	A0A3Q0GP26	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV3	TGFBR1	A0A1U7RQL9	A0A3Q0G355	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.572