STRINGSTRING
CYLD CYLD SOCS5 SOCS5 SMPDL3B SMPDL3B AHSG AHSG LACC1 LACC1 SNX4 SNX4 IRF3 IRF3 C1QTNF12 C1QTNF12 TNFRSF1B TNFRSF1B IL17RA IL17RA GGT1 GGT1 TNFSF11 TNFSF11 LOC102378183 LOC102378183 PDCD4 PDCD4 TNIP3 TNIP3 ADORA2A ADORA2A PTGS2 PTGS2 NFKBIA NFKBIA MCPH1 MCPH1 TNFAIP6 TNFAIP6 CDH5 CDH5 BCL6 BCL6 MDK MDK LOC102384045 LOC102384045 SPATA2 SPATA2 MAS1 MAS1 RHBDD3 RHBDD3 PPARG PPARG MGLL MGLL ANXA1 ANXA1 LOC102386002 LOC102386002 LGALS2 LGALS2 LOC102385606 LOC102385606 GHRL GHRL PTGES PTGES IL6ST IL6ST DUOXA2 DUOXA2 SEMA7A SEMA7A GHSR GHSR LGALS1 LGALS1 IL20RB IL20RB ADIPOQ ADIPOQ GRN GRN LOC102382338 LOC102382338 DUSP10 DUSP10 UFL1 UFL1 CTSC CTSC VPS35 VPS35 LOC102369160 LOC102369160 LOC102375729 LOC102375729 LOC102377912 LOC102377912 IL10 IL10 AOAH AOAH APP APP CCDC142 CCDC142 NLRX1 NLRX1 LOC102379481 LOC102379481 SETD4 SETD4 NCF1 NCF1 TNC TNC VAMP8 VAMP8 NT5E NT5E LYN LYN LOC102377845 LOC102377845 STAP1 STAP1 LOC102368581 LOC102368581 ACOD1 ACOD1 OTULIN OTULIN PTGER4 PTGER4 ADORA2B ADORA2B RICTOR RICTOR FFAR4 FFAR4 GPER1 GPER1 LOC102385854 LOC102385854 LOC102371832 LOC102371832 TNFAIP3 TNFAIP3 LOC102384158 LOC102384158 DNASE1L2 DNASE1L2 DNASE1 DNASE1 MYD88 MYD88 PPARA PPARA PBK PBK GPR4 GPR4 TNFAIP8L2 TNFAIP8L2 LOC102368757 LOC102368757 LOC102378088 LOC102378088 LOC102368313 LOC102368313 LOC102373125 LOC102373125 GPR68 GPR68 FNDC4 FNDC4 LOC102375342 LOC102375342 LOC102388249 LOC102388249 NR1D2 NR1D2 AREL1 AREL1 CCR7 CCR7 CUNH5orf30 CUNH5orf30 NDFIP1 NDFIP1 LRFN5 LRFN5 PPARD PPARD CST7 CST7 CUNH1orf210 CUNH1orf210 LRRK2 LRRK2 LOC102379211 LOC102379211 ASH1L ASH1L RIPK1 RIPK1 CX3CL1 CX3CL1 NR1H4 NR1H4 SHPK SHPK LOC102378316 LOC102378316 HGF HGF TLR3 TLR3 DROSHA DROSHA LOC102378738 LOC102378738 FANCD2 FANCD2 PARK7 PARK7 LOC102377148 LOC102377148 PIK3AP1 PIK3AP1 PDE2A PDE2A CD47 CD47 LOC102380945 LOC102380945 LOC102369595 LOC102369595 LOC112547978 LOC112547978 NLRC3 NLRC3 LOC102367907 LOC102367907 LOC102376243 LOC102376243 SOCS3 SOCS3 PSMB4 PSMB4 LOC102381106 LOC102381106 KARS KARS TTBK1 TTBK1 IL16 IL16 LPCAT3 LPCAT3 LOC102388056 LOC102388056 BCL6B BCL6B NAPEPLD NAPEPLD LOC102370285 LOC102370285 LOC102388654 LOC102388654 LOC102375912 LOC102375912 LOC102378507 LOC102378507 C2CD4C C2CD4C LOC102383266 LOC102383266 SELENOS SELENOS SETD6 SETD6 LOC102388003 LOC102388003 MVK MVK LOC102368598 LOC102368598 IFI35 IFI35 TNIP1 TNIP1 WFDC1 WFDC1 PLA2G10 PLA2G10 NR1D1 NR1D1 MKRN2 MKRN2 PTPN2 PTPN2 NMI NMI ESR1 ESR1 ZBP1 ZBP1 IL18 IL18 MFHAS1 MFHAS1 DAGLA DAGLA LRRC19 LRRC19 DAGLB DAGLB FANCA FANCA NOV NOV PROC PROC GPR17 GPR17 IL6 IL6 OSMR OSMR RB1 RB1 METRNL METRNL LOC102377832 LOC102377832 TNFRSF11A TNFRSF11A SYT11 SYT11 LOC102369661 LOC102369661 RABGEF1 RABGEF1 BST1 BST1 GATA3 GATA3 IL1RL1 IL1RL1 LOC102380114 LOC102380114 AKNA AKNA LETMD1 LETMD1 TNFRSF1A TNFRSF1A LOC102382176 LOC102382176 LOC102384544 LOC102384544 LOC112551723 LOC112551723 PGLYRP2 PGLYRP2 LOC102387876 LOC102387876 FAM19A3 FAM19A3 LOC102373345 LOC102373345 NFKBIZ NFKBIZ LOC102378324 LOC102378324
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (954 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (460 aa)
AHSGalpha-2-HS-glycoprotein. (347 aa)
LACC1Laccase domain-containing protein 1 isoform X1. (439 aa)
SNX4Sorting nexin-4 isoform X1. (409 aa)
IRF3Interferon regulatory factor 3 isoform X2. (432 aa)
C1QTNF12Adipolin isoform X1. (320 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B. (493 aa)
IL17RAInterleukin-17 receptor A. (805 aa)
GGT1Glutathione hydrolase 1 proenzyme isoform X1. (567 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (238 aa)
LOC102378183Malignant fibrous histiocytoma-amplified sequence 1 homolog. (263 aa)
PDCD4Programmed cell death protein 4. (468 aa)
TNIP3TNFAIP3-interacting protein 3 isoform X1. (408 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (436 aa)
PTGS2Prostaglandin G/H synthase 2. (605 aa)
NFKBIANF-kappa-B inhibitor alpha. (316 aa)
MCPH1Microcephalin isoform X1. (850 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein. (275 aa)
CDH5Cadherin-5 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (778 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (708 aa)
MDKMidkine isoform X1. (142 aa)
LOC102384045Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
SPATA2Spermatogenesis-associated protein 2. (523 aa)
MAS1Proto-oncogene Mas; Belongs to the G-protein coupled receptor 1 family. (332 aa)
RHBDD3Rhomboid domain-containing protein 3. (415 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
MGLLMonoglyceride lipase isoform X1. (309 aa)
ANXA1Annexin. (342 aa)
LOC102386002Dual oxidase maturation factor 1. (324 aa)
LGALS2Galectin. (181 aa)
LOC102385606Zona pellucida sperm-binding protein 3-like. (479 aa)
GHRLAppetite-regulating hormone isoform X1. (145 aa)
PTGESProstaglandin E synthase isoform X1. (146 aa)
IL6STInterleukin-6 receptor subunit beta. (919 aa)
DUOXA2Dual oxidase maturation factor 2. (323 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (630 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (310 aa)
LGALS1Galectin. (134 aa)
IL20RBInterleukin-20 receptor subunit beta. (315 aa)
ADIPOQAdiponectin. (243 aa)
GRNGranulins. (894 aa)
LOC102382338OX-2 membrane glycoprotein-like. (311 aa)
DUSP10Dual specificity protein phosphatase 10. (479 aa)
UFL1E3 UFM1-protein ligase 1. (755 aa)
CTSCDipeptidyl peptidase 1; Belongs to the peptidase C1 family. (425 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (804 aa)
LOC102369160Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
LOC102375729Phospholipase A(2). (137 aa)
LOC102377912Interleukin-1 receptor type 1. (566 aa)
IL10Interleukin-10. (177 aa)
AOAHAcyloxyacyl hydrolase. (584 aa)
APPAmyloid-beta A4 protein isoform X1. (716 aa)
CCDC142Coiled-coil domain-containing protein 142. (583 aa)
NLRX1NLR family member X1. (980 aa)
LOC102379481Galectin. (134 aa)
SETD4SET domain-containing protein 4. (440 aa)
NCF1Neutrophil cytosol factor 1. (389 aa)
TNCTenascin isoform X1. (2437 aa)
VAMP8Vesicle-associated membrane protein 8. (115 aa)
NT5E5'-nucleotidase; Belongs to the 5'-nucleotidase family. (470 aa)
LYNTyrosine-protein kinase. (513 aa)
LOC102377845Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (364 aa)
STAP1Signal-transducing adaptor protein 1. (312 aa)
LOC102368581Zona pellucida sperm-binding protein 3-like. (495 aa)
ACOD1Cis-aconitate decarboxylase. (474 aa)
OTULINUbiquitin thioesterase otulin isoform X1. (442 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Belongs to the G-protein coupled receptor 1 family. (486 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (335 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1674 aa)
FFAR4Free fatty acid receptor 4. (185 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LOC102385854Gamma-interferon-inducible protein 16-like. (325 aa)
LOC102371832C2 calcium-dependent domain-containing protein 4C-like. (429 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3 isoform X1. (817 aa)
LOC102384158Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (846 aa)
DNASE1L2Deoxyribonuclease-1-like 2 isoform X1. (375 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (284 aa)
MYD88Myeloid differentiation primary response protein MyD88. (211 aa)
PPARAPeroxisome proliferator-activated receptor alpha isoform X1. (468 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase isoform X1. (325 aa)
GPR4G-protein coupled receptor 4. (156 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2. (356 aa)
LOC102368757Adenosine receptor A1-like. (354 aa)
LOC102378088Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (322 aa)
LOC102368313Probable G-protein coupled receptor 132. (305 aa)
LOC102373125Apoptosis-associated speck-like protein containing a CARD. (192 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (363 aa)
FNDC4Fibronectin type III domain-containing protein 4 isoform X1. (317 aa)
LOC102375342Galectin. (138 aa)
LOC102388249Cell surface glycoprotein CD200 receptor 1-B-like. (302 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2 isoform X2. (588 aa)
AREL1Apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1. (859 aa)
CCR7C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (315 aa)
CUNH5orf30UNC119-binding protein C5orf30 homolog. (207 aa)
NDFIP1NEDD4 family-interacting protein 1. (207 aa)
LRFN5Leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform X1. (776 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (442 aa)
CST7cystatin-F isoform X1. (169 aa)
CUNH1orf210Type III endosome membrane protein TEMP. (393 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2 isoform X1. (2410 aa)
LOC102379211Growth hormone secretagogue receptor type 1-like; Belongs to the G-protein coupled receptor 1 family. (349 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L isoform X1. (3150 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (711 aa)
CX3CL1Fractalkine isoform X1. (549 aa)
NR1H4Bile acid receptor. (465 aa)
SHPKSedoheptulokinase. (380 aa)
LOC102378316Interleukin-1 receptor-like 2 isoform X1. (585 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (681 aa)
TLR3Toll-like receptor 3 isoform X1; Belongs to the Toll-like receptor family. (905 aa)
DROSHARibonuclease 3 isoform X1. (1338 aa)
LOC102378738Tumor necrosis factor. (231 aa)
FANCD2Fanconi anemia group D2 protein isoform X1. (1459 aa)
PARK7Protein/nucleic acid deglycase DJ-1. (189 aa)
LOC102377148Cis-aconitate decarboxylase-like. (490 aa)
PIK3AP1Phosphoinositide 3-kinase adapter protein 1. (633 aa)
PDE2APhosphodiesterase. (906 aa)
CD47Leukocyte surface antigen CD47 isoform X1. (292 aa)
LOC102380945C2 calcium-dependent domain-containing protein 4B-like. (288 aa)
LOC102369595Interleukin-1; Belongs to the IL-1 family. (279 aa)
LOC112547978Interleukin-1. (241 aa)
NLRC3NLR family CARD domain-containing protein 3. (1093 aa)
LOC102367907semaphorin-7A-like; Belongs to the semaphorin family. (629 aa)
LOC102376243Programmed cell death protein 4. (319 aa)
SOCS3Suppressor of cytokine signaling 3. (174 aa)
PSMB4LOW QUALITY PROTEIN: proteasome subunit beta type-4. (305 aa)
LOC102381106NACHT, LRR and PYD domains-containing protein 12-like. (1039 aa)
KARSLysine--tRNA ligase. (639 aa)
TTBK1Tau-tubulin kinase 1. (1330 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1507 aa)
LPCAT3Lysophospholipid acyltransferase 5 isoform X1; Belongs to the membrane-bound acyltransferase family. (514 aa)
LOC102388056NACHT, LRR and PYD domains-containing protein 1b allele 2-like isoform X1. (698 aa)
BCL6BB-cell CLL/lymphoma 6 member B protein isoform X1. (503 aa)
NAPEPLDN-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1. (428 aa)
LOC102370285NACHT, LRR and PYD domains-containing protein 1b allele 2-like. (427 aa)
LOC102388654Protein NKG7-like. (180 aa)
LOC102375912Galectin. (201 aa)
LOC102378507NACHT, LRR and PYD domains-containing protein 3-like isoform X1. (894 aa)
C2CD4CLOW QUALITY PROTEIN: C2 calcium-dependent domain-containing protein 4C. (394 aa)
LOC102383266NACHT, LRR and PYD domains-containing protein 3-like. (960 aa)
SELENOSSelenoprotein S. (188 aa)
SETD6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (479 aa)
LOC102388003Cell surface glycoprotein CD200 receptor 1-A-like. (337 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (326 aa)
LOC102368598Phospholipase A(2). (226 aa)
IFI35Interferon-induced 35 kDa protein. (378 aa)
TNIP1TNFAIP3-interacting protein 1. (524 aa)
WFDC1WAP four-disulfide core domain protein 1 isoform X1. (229 aa)
PLA2G10Phospholipase A(2). (182 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X1. (637 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2. (409 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (447 aa)
NMILOW QUALITY PROTEIN: N-myc-interactor. (393 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
ZBP1Z-DNA-binding protein 1 isoform X1. (436 aa)
IL18Interleukin-18 isoform X1. (231 aa)
MFHAS1Malignant fibrous histiocytoma-amplified sequence 1. (1061 aa)
DAGLASn1-specific diacylglycerol lipase alpha. (1031 aa)
LRRC19Leucine-rich repeat-containing protein 19. (396 aa)
DAGLBSn1-specific diacylglycerol lipase beta. (598 aa)
FANCAFanconi anemia group A protein. (1436 aa)
NOVProtein NOV homolog. (270 aa)
PROCVitamin K-dependent protein C isoform X1. (445 aa)
GPR17Uracil nucleotide/cysteinyl leukotriene receptor; Belongs to the G-protein coupled receptor 1 family. (338 aa)
IL6Interleukin-6. (152 aa)
OSMRoncostatin-M-specific receptor subunit beta. (983 aa)
RB1Retinoblastoma-associated protein isoform X1. (905 aa)
METRNLMeteorin-like protein isoform X1. (292 aa)
LOC102377832Nuclear receptor subfamily 1 group D member 1-like. (516 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (669 aa)
SYT11Synaptotagmin-11 isoform X1. (373 aa)
LOC102369661Plasminogen activator inhibitor 1; Belongs to the serpin family. (408 aa)
RABGEF1Rab5 GDP/GTP exchange factor isoform X1. (539 aa)
BST1ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2. (501 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (385 aa)
IL1RL1Interleukin-1 receptor-like 1 isoform X1. (555 aa)
LOC102380114Mucin-17-like isoform X1. (495 aa)
AKNAAT-hook-containing transcription factor. (1532 aa)
LETMD1LETM1 domain-containing protein 1 isoform X1. (312 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (418 aa)
LOC102382176OX-2 membrane glycoprotein-like. (372 aa)
LOC102384544OX-2 membrane glycoprotein-like isoform X1. (320 aa)
LOC112551723OX-2 membrane glycoprotein-like. (372 aa)
PGLYRP2LOW QUALITY PROTEIN: N-acetylmuramoyl-L-alanine amidase. (514 aa)
LOC102387876NACHT, LRR and PYD domains-containing protein 3-like. (1185 aa)
FAM19A3Protein FAM19A3 isoform X1. (176 aa)
LOC102373345Caspase-1-like isoform X1; Belongs to the peptidase C14A family. (414 aa)
NFKBIZNF-kappa-B inhibitor zeta isoform X1. (625 aa)
LOC102378324Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (324 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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