STRINGSTRING
EDNRB EDNRB SIX2 SIX2 BMP2 BMP2 RET RET NKX2-5 NKX2-5 FGF2 FGF2 WNT11 WNT11 TGFB2 TGFB2 FBXL17 FBXL17 FN1 FN1 FGF19 FGF19 TBX20 TBX20 ANXA6 ANXA6 PDCD6 PDCD6 RDH10 RDH10 SEMA4D SEMA4D PAX1 PAX1 SOX10 SOX10 FOXC2 FOXC2 LOC102375759 LOC102375759 SEMA3C SEMA3C TGFBR3 TGFBR3 EDNRA EDNRA SEMA3F SEMA3F GDNF GDNF SFRP2 SFRP2 NRP2 NRP2 HOXA5 HOXA5 MEOX1 MEOX1 FAM172A FAM172A TMEM100 TMEM100 HAND1 HAND1 LOC102387697 LOC102387697 SNAI2 SNAI2 FGFR2 FGFR2 SEMA7A SEMA7A PEF1 PEF1 PHACTR4 PHACTR4 LOC102383236 LOC102383236 EOMES EOMES HAND2 HAND2 WNT2 WNT2 HTR2B HTR2B KBTBD8 KBTBD8 SEMA3A SEMA3A BMP7 BMP7 SEMA6A SEMA6A LOXL2 LOXL2 SMO SMO TGFBR2 TGFBR2 EDN1 EDN1 CTNNB1 CTNNB1 LRP6 LRP6 BMP4 BMP4 OTUD5 OTUD5 SEMA3D SEMA3D SEMA6C SEMA6C KLHL12 KLHL12 ROCK1 ROCK1 GATA4 GATA4 SOX9 SOX9 SMAD3 SMAD3 ENG ENG TCF15 TCF15 DDX17 DDX17 JAG1 JAG1 POLR1B POLR1B TCF21 TCF21 BCL2 BCL2 EXOC4 EXOC4 SEMA4B SEMA4B BMP5 BMP5 WWTR1 WWTR1 SCX SCX LOC102388290 LOC102388290 SEMA5B SEMA5B TGFB1 TGFB1 AMH AMH SIX4 SIX4 LOC102385749 LOC102385749 LOC102371879 LOC102371879 BMPR2 BMPR2 SEMA5A SEMA5A PHOX2B PHOX2B FAM208A FAM208A MDM4 MDM4 RFLNB RFLNB WNT2B WNT2B CRELD1 CRELD1 LOC102372246 LOC102372246 LOC102387076 LOC102387076 LOC106723518 LOC106723518 PTK7 PTK7 LOC102367907 LOC102367907 WNT16 WNT16 LOXL3 LOXL3 SEMA4F SEMA4F SMAD2 SMAD2 TAF10 TAF10 TBX3 TBX3 LOC102376089 LOC102376089 NUP133 NUP133 SEMA6B SEMA6B NRTN NRTN DDX5 DDX5 ZFP64 ZFP64 DLG5 DLG5 POGLUT1 POGLUT1 TGFBR1 TGFBR1 PKD2 PKD2 SNAI1 SNAI1 ACVR1 ACVR1 PWWP2A PWWP2A TCOF1 TCOF1 BNC2 BNC2 SEMA4G SEMA4G PPP3R1 PPP3R1 SEMA3E SEMA3E SEMA3B SEMA3B SOX8 SOX8 FGFR1 FGFR1 GATA5 GATA5 GSC GSC EPB41L5 EPB41L5 NRP1 NRP1 LOC106721794 LOC106721794 SEMA3G SEMA3G ALCAM ALCAM TBX2 TBX2 TAPT1 TAPT1 AMER1 AMER1 LOC102387029 LOC102387029 SEMA6D SEMA6D ACVRL1 ACVRL1 LOC102373921 LOC102373921 EFNA1 EFNA1 LEF1 LEF1 AKNA AKNA SEMA4C SEMA4C LOC102368464 LOC102368464 YAP1 YAP1 LOC102378884 LOC102378884 RANBP3L RANBP3L SMAD4 SMAD4 LOC102382089 LOC102382089 NOLC1 NOLC1 LOC102388045 LOC102388045 FGF8 FGF8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (269 aa)
SIX2Homeobox protein SIX2. (259 aa)
BMP2Bone morphogenetic protein 2. (297 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
NKX2-5Homeobox protein Nkx-2.5. (218 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (134 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (413 aa)
FBXL17F-box/LRR-repeat protein 17. (237 aa)
FN1Fibronectin isoform X1. (2475 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
TBX20T-box transcription factor TBX20. (439 aa)
ANXA6Annexin. (675 aa)
PDCD6Programmed cell death protein 6 isoform X2. (173 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
SEMA4Dsemaphorin-4D isoform X1; Belongs to the semaphorin family. (856 aa)
PAX1Paired box protein Pax-1. (367 aa)
SOX10Transcription factor SOX-10. (463 aa)
FOXC2Forkhead box protein C2. (283 aa)
LOC102375759Forkhead box protein D3-B-like. (265 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
TGFBR3Transforming growth factor beta receptor type 3 isoform X1. (885 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (417 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (798 aa)
GDNFGlial cell line-derived neurotrophic factor. (159 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (942 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
MEOX1Homeobox protein MOX-1. (248 aa)
FAM172AProtein FAM172A. (297 aa)
TMEM100Transmembrane protein 100. (134 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (126 aa)
LOC102387697Protein FAM172A. (158 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
FGFR2Fibroblast growth factor receptor. (869 aa)
SEMA7Asemaphorin-7A; Belongs to the semaphorin family. (630 aa)
PEF1Peflin. (284 aa)
PHACTR4Phosphatase and actin regulator. (699 aa)
LOC102383236Homeobox protein GBX-2. (290 aa)
EOMESEomesodermin homolog isoform X1. (414 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (116 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
HTR2B5-hydroxytryptamine receptor 2B isoform X1. (482 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (575 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (771 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1041 aa)
LOXL2Lysyl oxidase homolog 2 isoform X1. (613 aa)
SMOSmoothened homolog isoform X1; Belongs to the G-protein coupled receptor Fz/Smo family. (803 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
EDN1Endothelin-1. (200 aa)
CTNNB1Catenin beta-1. (784 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1604 aa)
BMP4Bone morphogenetic protein 4. (341 aa)
OTUD5OTU domain-containing protein 5. (344 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (793 aa)
SEMA6CLOW QUALITY PROTEIN: semaphorin-6C; Belongs to the semaphorin family. (1031 aa)
KLHL12Kelch-like protein 12 isoform X1. (564 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
GATA4Transcription factor GATA-4 isoform X1. (410 aa)
SOX9Transcription factor SOX-9. (494 aa)
SMAD3Mothers against decapentaplegic homolog. (321 aa)
ENGEndoglin. (667 aa)
TCF15Transcription factor 15. (360 aa)
DDX17Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family. (655 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1050 aa)
TCF21Transcription factor 21. (179 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (214 aa)
EXOC4Exocyst complex component 4. (974 aa)
SEMA4Bsemaphorin-4B isoform X1; Belongs to the semaphorin family. (811 aa)
BMP5Bone morphogenetic protein 5. (453 aa)
WWTR1WW domain-containing transcription regulator protein 1. (261 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (134 aa)
LOC102388290Protein FAM83D-like. (211 aa)
SEMA5BLOW QUALITY PROTEIN: semaphorin-5B. (1006 aa)
TGFB1Transforming growth factor beta-1. (235 aa)
AMHMuellerian-inhibiting factor. (677 aa)
SIX4Homeobox protein SIX4. (510 aa)
LOC102385749Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (478 aa)
LOC102371879TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
SEMA5Asemaphorin-5A. (1077 aa)
PHOX2BPaired mesoderm homeobox protein 2B. (155 aa)
FAM208AProtein TASOR. (1541 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (474 aa)
RFLNBrefilin-B. (159 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
CRELD1Cysteine-rich with EGF-like domain protein 1. (189 aa)
LOC102372246LOW QUALITY PROTEIN: F-box/LRR-repeat protein 17-like. (135 aa)
LOC102387076LOW QUALITY PROTEIN: homeobox protein six1. (173 aa)
LOC106723518Forkhead box protein C2-like. (79 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1099 aa)
LOC102367907semaphorin-7A-like; Belongs to the semaphorin family. (629 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (257 aa)
LOXL3Lysyl oxidase homolog 3. (661 aa)
SEMA4FLOW QUALITY PROTEIN: semaphorin-4F; Belongs to the semaphorin family. (772 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TAF10LOW QUALITY PROTEIN: transcription initiation factor TFIID subunit 10. (134 aa)
TBX3T-box transcription factor TBX3. (708 aa)
LOC102376089semaphorin-4A isoform X1; Belongs to the semaphorin family. (882 aa)
NUP133Nuclear pore complex protein Nup133. (1062 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (909 aa)
NRTNNeurturin isoform X1. (266 aa)
DDX5Probable ATP-dependent RNA helicase DDX5; Belongs to the DEAD box helicase family. (611 aa)
ZFP64Zinc finger protein 64. (729 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1969 aa)
POGLUT1Protein O-glucosyltransferase 1. (396 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (440 aa)
PKD2Polycystin-2 isoform X1. (766 aa)
SNAI1Zinc finger protein SNAI1. (197 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (553 aa)
PWWP2APWWP domain-containing protein 2A isoform X1. (590 aa)
TCOF1Treacle protein. (1116 aa)
BNC2Zinc finger protein basonuclin-2. (1072 aa)
SEMA4GLOW QUALITY PROTEIN: semaphorin-4G; Belongs to the semaphorin family. (643 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (774 aa)
SEMA3Bsemaphorin-3B isoform X1; Belongs to the semaphorin family. (811 aa)
SOX8Transcription factor SOX-8. (417 aa)
FGFR1Fibroblast growth factor receptor. (909 aa)
GATA5Transcription factor GATA-5. (395 aa)
GSCLOW QUALITY PROTEIN: homeobox protein goosecoid. (247 aa)
EPB41L5Band 4.1-like protein 5 isoform X1. (736 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (921 aa)
LOC106721794semaphorin-4D-like; Belongs to the semaphorin family. (576 aa)
SEMA3Gsemaphorin-3G isoform X1; Belongs to the semaphorin family. (779 aa)
ALCAMCD166 antigen isoform X1. (570 aa)
TBX2T-box transcription factor TBX2. (341 aa)
TAPT1Transmembrane anterior posterior transformation protein 1 homolog isoform X1. (474 aa)
AMER1LOW QUALITY PROTEIN: APC membrane recruitment protein 1. (1145 aa)
LOC102387029Lysyl oxidase homolog 2-like. (193 aa)
SEMA6Dsemaphorin-6D; Belongs to the semaphorin family. (1088 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (523 aa)
LOC102373921Mothers against decapentaplegic homolog. (405 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (298 aa)
LEF1Lymphoid enhancer-binding factor 1. (349 aa)
AKNAAT-hook-containing transcription factor. (1532 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (837 aa)
LOC102368464LOW QUALITY PROTEIN: uncharacterized protein LOC102368464. (355 aa)
YAP1Transcriptional coactivator YAP1 isoform X1. (409 aa)
LOC102378884semaphorin-3D-like; Belongs to the semaphorin family. (827 aa)
RANBP3LRan-binding protein 3-like isoform X1. (561 aa)
SMAD4Mothers against decapentaplegic homolog. (554 aa)
LOC102382089Endothelin receptor type B-like; Belongs to the G-protein coupled receptor 1 family. (437 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (738 aa)
LOC102388045Protein FAM83D-like. (407 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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