(24 nodes) Regulation of necroptotic process network (Alligator sinensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1 isoform X1. (711 aa)
	BOK	Bcl-2-related ovarian killer protein isoform X1. (251 aa)
	YBX3	Y-box-binding protein 3. (235 aa)
	RIPK3	Receptor-interacting serine/threonine-protein kinase 3 isoform X1. (509 aa)
	RNF31	E3 ubiquitin-protein ligase RNF31. (930 aa)
	CFLAR	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (507 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (543 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog 1. (418 aa)
	LOC102369160	Ubiquitin carboxyl-terminal hydrolase CYLD-like; Belongs to the peptidase C19 family. (788 aa)
	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (954 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	SPATA2	Spermatogenesis-associated protein 2. (523 aa)
	FADD	FAS-associated death domain protein. (191 aa)
	LOC102384848	Caspase-8-like; Belongs to the peptidase C14A family. (556 aa)
	LOC102385102	Caspase-8-like; Belongs to the peptidase C14A family. (479 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (128 aa)
	ZBP1	Z-DNA-binding protein 1 isoform X1. (436 aa)
	CASP6	Caspase-6 isoform X2; Belongs to the peptidase C14A family. (308 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (596 aa)
	RBCK1	ranBP-type and C3HC4-type zinc finger-containing protein 1. (852 aa)
	LOC102368067	Inhibitor of apoptosis protein-like. (633 aa)
	SHARPIN	LOW QUALITY PROTEIN: sharpin. (588 aa)
	LOC112551715	ranBP-type and C3HC4-type zinc finger-containing protein 1-like. (123 aa)
	ADPRHL2	poly(ADP-ribose) glycohydrolase ARH3. (284 aa)

Your Current Organism:

Alligator sinensis

NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BOK	LOC102384848	A0A1U8DSV4	A0A3Q0GIH6	Bcl-2-related ovarian killer protein isoform X1.	Caspase-8-like; Belongs to the peptidase C14A family.	0.429
BOK	LOC102385102	A0A1U8DSV4	A0A3Q0GII1	Bcl-2-related ovarian killer protein isoform X1.	Caspase-8-like; Belongs to the peptidase C14A family.	0.488
CASP10	CASP6	A0A1U8D075	A0A3Q0GRV0	Caspase-10; Belongs to the peptidase C14A family.	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	0.574
CASP10	CFLAR	A0A1U8D075	A0A3Q0GEI0	Caspase-10; Belongs to the peptidase C14A family.	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family.	0.834
CASP10	FADD	A0A1U8D075	A0A1U7QZJ2	Caspase-10; Belongs to the peptidase C14A family.	FAS-associated death domain protein.	0.989
CASP10	LOC102368067	A0A1U8D075	A0A3Q0HET8	Caspase-10; Belongs to the peptidase C14A family.	Inhibitor of apoptosis protein-like.	0.490
CASP10	LOC102384848	A0A1U8D075	A0A3Q0GIH6	Caspase-10; Belongs to the peptidase C14A family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.800
CASP10	LOC102385102	A0A1U8D075	A0A3Q0GII1	Caspase-10; Belongs to the peptidase C14A family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.806
CASP10	RIPK1	A0A1U8D075	A0A1U8DC48	Caspase-10; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.886
CASP10	RIPK3	A0A1U8D075	A0A3Q0FSA0	Caspase-10; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 3 isoform X1.	0.867
CASP6	CASP10	A0A3Q0GRV0	A0A1U8D075	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	Caspase-10; Belongs to the peptidase C14A family.	0.574
CASP6	FADD	A0A3Q0GRV0	A0A1U7QZJ2	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	FAS-associated death domain protein.	0.501
CASP6	LOC102368067	A0A3Q0GRV0	A0A3Q0HET8	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	Inhibitor of apoptosis protein-like.	0.577
CASP6	LOC102384848	A0A3Q0GRV0	A0A3Q0GIH6	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.955
CASP6	LOC102385102	A0A3Q0GRV0	A0A3Q0GII1	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	Caspase-8-like; Belongs to the peptidase C14A family.	0.955
CASP6	RIPK1	A0A3Q0GRV0	A0A1U8DC48	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 1 isoform X1.	0.556
CASP6	RIPK3	A0A3Q0GRV0	A0A3Q0FSA0	Caspase-6 isoform X2; Belongs to the peptidase C14A family.	Receptor-interacting serine/threonine-protein kinase 3 isoform X1.	0.654
CAV1	CAV3	A0A3Q0GJR4	A0A1U7RQL9	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.961
CAV3	CAV1	A0A1U7RQL9	A0A3Q0GJR4	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.961
CFLAR	CASP10	A0A3Q0GEI0	A0A1U8D075	CASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family.	Caspase-10; Belongs to the peptidase C14A family.	0.834