STRINGSTRING
CTNNB1 CTNNB1 FGF8 FGF8 LOC102382012 LOC102382012 ST14 ST14 SMAD4 SMAD4 WT1 WT1 LOC102368464 LOC102368464 LOC102385059 LOC102385059 LEF1 LEF1 MKS1 MKS1 LOC102373921 LOC102373921 VDR VDR TMEM59L TMEM59L SLIT2 SLIT2 HNF1B HNF1B TBX2 TBX2 PKD1 PKD1 LOC102376036 LOC102376036 HOXA13 HOXA13 LOC112550716 LOC112550716 TIE1 TIE1 SPINT1 SPINT1 PLXND1 PLXND1 MET MET DLL4 DLL4 ESR1 ESR1 SOX8 SOX8 SEMA3E SEMA3E GREB1 GREB1 PPP3R1 PPP3R1 TP63 TP63 LOC102382623 LOC102382623 LOC102374608 LOC102374608 GLI3 GLI3 AR AR ACVR1 ACVR1 LOC102372873 LOC102372873 CLIC4 CLIC4 LOC102368480 LOC102368480 LRP5 LRP5 LOC102372537 LOC102372537 ESRP2 ESRP2 PKD2 PKD2 KDR KDR TMED2 TMED2 DLG5 DLG5 LOC102384916 LOC102384916 WNT9B WNT9B LOC102381867 LOC102381867 TBX3 TBX3 SOCS3 SOCS3 FEM1B FEM1B LOC102378099 LOC102378099 TIMELESS TIMELESS CSF1 CSF1 FRS2 FRS2 MED1 MED1 CTSZ CTSZ EPHA2 EPHA2 LOC102381382 LOC102381382 LOC102371879 LOC102371879 LOC102386815 LOC102386815 TGFB1 TGFB1 SRF SRF NFATC4 NFATC4 ILK ILK MMP14 MMP14 WNT6 WNT6 LOC102385493 LOC102385493 BCL2 BCL2 TCF21 TCF21 WNT1 WNT1 ENG ENG SOX9 SOX9 DDR1 DDR1 NKX3-1 NKX3-1 RSPO3 RSPO3 BTBD7 BTBD7 EDN1 EDN1 TGFBR2 TGFBR2 DAG1 DAG1 IL10 IL10 GCM1 GCM1 GDF7 GDF7 FGF1 FGF1 HOXB13 HOXB13 LOC102383236 LOC102383236 LOC102378535 LOC102378535 CTSH CTSH HOXA5 HOXA5 HOXD13 HOXD13 SFRP2 SFRP2 GDNF GDNF GREB1L GREB1L EDNRA EDNRA PLEKHH1 PLEKHH1 SEMA3C SEMA3C ETV4 ETV4 SOX10 SOX10 RDH10 RDH10 TBX20 TBX20 AREG AREG PTCH1 PTCH1 PML PML GZF1 GZF1 SPRY1 SPRY1 GNA13 GNA13 CTNNBIP1 CTNNBIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CTNNB1Catenin beta-1. (784 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (245 aa)
LOC102382012Fibrocystin. (1812 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. (842 aa)
SMAD4Mothers against decapentaplegic homolog. (554 aa)
WT1Wilms tumor protein. (294 aa)
LOC102368464LOW QUALITY PROTEIN: uncharacterized protein LOC102368464. (355 aa)
LOC102385059Suppressor of tumorigenicity 14 protein-like. (817 aa)
LEF1Lymphoid enhancer-binding factor 1. (349 aa)
MKS1Meckel syndrome type 1 protein. (417 aa)
LOC102373921Mothers against decapentaplegic homolog. (405 aa)
VDRVitamin D3 receptor. (520 aa)
TMEM59LTransmembrane protein 59-like isoform X1. (326 aa)
SLIT2Slit homolog 2 protein. (1435 aa)
HNF1BHepatocyte nuclear factor 1-beta. (513 aa)
TBX2T-box transcription factor TBX2. (341 aa)
PKD1Polycystin-1. (4304 aa)
LOC102376036Fibrocystin-like. (2284 aa)
HOXA13LOW QUALITY PROTEIN: homeobox protein Hox-A13. (316 aa)
LOC112550716Tyrosine-protein kinase receptor Tie-1-like. (140 aa)
TIE1Tyrosine-protein kinase receptor Tie-1. (964 aa)
SPINT1Kunitz-type protease inhibitor 1. (448 aa)
PLXND1plexin-D1. (1534 aa)
METHepatocyte growth factor receptor isoform X1. (1384 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (615 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (627 aa)
SOX8Transcription factor SOX-8. (417 aa)
SEMA3Esemaphorin-3E; Belongs to the semaphorin family. (774 aa)
GREB1Protein GREB1. (1951 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LOC102382623Uncharacterized protein LOC102382623 isoform X1. (195 aa)
LOC102374608GDNF-inducible zinc finger protein 1-like isoform X1. (1041 aa)
GLI3Transcriptional activator GLI3 isoform X1. (1584 aa)
ARAndrogen receptor isoform X2. (430 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (553 aa)
LOC102372873Protein PML-like isoform X1. (652 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (255 aa)
LOC102368480Transmembrane emp24 domain-containing protein 2-like isoform X1. (206 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1593 aa)
LOC102372537Polycystin-1-like. (4207 aa)
ESRP2LOW QUALITY PROTEIN: epithelial splicing regulatory protein 2. (732 aa)
PKD2Polycystin-2 isoform X1. (766 aa)
KDRVascular endothelial growth factor receptor 2 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1269 aa)
TMED2Transmembrane emp24 domain-containing protein 2 isoform X1. (208 aa)
DLG5Disks large homolog 5 isoform X1; Belongs to the MAGUK family. (1969 aa)
LOC102384916Dentin sialophosphoprotein. (834 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC102381867F-box/WD repeat-containing protein 1A. (517 aa)
TBX3T-box transcription factor TBX3. (708 aa)
SOCS3Suppressor of cytokine signaling 3. (174 aa)
FEM1BProtein fem-1 homolog B. (553 aa)
LOC102378099Hedgehog-interacting protein-like isoform X1. (185 aa)
TIMELESSLOW QUALITY PROTEIN: protein timeless homolog. (1194 aa)
CSF1Macrophage colony-stimulating factor 1. (567 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1565 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (259 aa)
EPHA2Ephrin type-A receptor 2. (1000 aa)
LOC102381382Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
LOC102371879TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
LOC102386815Hedgehog-interacting protein-like. (454 aa)
TGFB1Transforming growth factor beta-1. (235 aa)
SRFSerum response factor isoform X1. (412 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (831 aa)
ILKIntegrin-linked protein kinase. (452 aa)
MMP14Matrix metalloproteinase-14. (570 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (435 aa)
LOC102385493Epithelial discoidin domain-containing receptor 1-like. (232 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (214 aa)
TCF21Transcription factor 21. (179 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (341 aa)
ENGEndoglin. (667 aa)
SOX9Transcription factor SOX-9. (494 aa)
DDR1Epithelial discoidin domain-containing receptor 1 isoform X1. (833 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (232 aa)
RSPO3R-spondin-3. (274 aa)
BTBD7BTB/POZ domain-containing protein 7. (1121 aa)
EDN1Endothelin-1. (200 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (531 aa)
DAG1Dystroglycan isoform X1. (894 aa)
IL10Interleukin-10. (177 aa)
GCM1Chorion-specific transcription factor GCMa. (446 aa)
GDF7Growth/differentiation factor 7. (216 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
HOXB13Homeobox protein Hox-B13. (296 aa)
LOC102383236Homeobox protein GBX-2. (290 aa)
LOC102378535Protein PML-like isoform X1. (852 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (334 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
HOXD13Homeobox protein Hox-D13. (239 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
GDNFGlial cell line-derived neurotrophic factor. (159 aa)
GREB1LLOW QUALITY PROTEIN: GREB1-like protein. (1966 aa)
EDNRAEndothelin-1 receptor; Belongs to the G-protein coupled receptor 1 family. (417 aa)
PLEKHH1LOW QUALITY PROTEIN: pleckstrin homology domain-containing family H member 1. (1440 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
ETV4ETS translocation variant 4. (299 aa)
SOX10Transcription factor SOX-10. (463 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
TBX20T-box transcription factor TBX20. (439 aa)
AREGAmphiregulin. (226 aa)
PTCH1Protein patched homolog 1 isoform X1. (1326 aa)
PMLProtein PML. (586 aa)
GZF1GDNF-inducible zinc finger protein 1 isoform X1. (719 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (320 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (310 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
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